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Found 73 clinical trials
A Trial of BI 765063 Monotherapy and in Combination With BI 754091 in Patients With Advanced Solid Tumours

This trial will be a two steps Phase I clinical study in patients with advanced solid tumors with an escalating phase (Step 1) followed by an expansion phase (Step 2) of BI 765063, a monoclonal

ovarian cancer
squamous cell carcinoma of the head and neck
platelet count
targeted therapy
solid tumour
  • 15 views
  • 22 Jan, 2021
  • 5 locations
Phase II Trial of Ribociclib and Everolimus in Advanced Dedifferentiated Liposarcoma (DDL) and Leiomyosarcoma (LMS)

all the eligibility criteria necessary for step 1. For step 2 registration, patients must meet the inclusion criteria necessary for step 2 to be enrolled into the study.

immunomodulators
leiomyosarcoma
liposarcoma
metastasis
systemic therapy
  • 28 views
  • 25 Jan, 2021
  • 2 locations
Cognitive vs. Emotional Psychopharmacological Manipulations of Fear vs. Anxiety

(propranolol) domain, and using a single cognitive process (working memory). In a second step (step-2), we propose to extend this work to the fMRI to examine the cognitive correlates of the effects seen in the

psychiatric disorder
social interaction
anxiolytics
alprazolam
anxiety
  • 35 views
  • 03 Mar, 2021
  • 1 location
Radiotherapy as an Immunological Booster in Patients With Metastatic Melanoma or Renal Cell Carcinoma Treated With High-dose Interleukin-2

: Step 1: 7 patients enrolled If tumor antigen-specific immune response is observed in at least 3 patients: Step 2: recruitment of an additional 12 patients

ct scan
metastatic melanoma
ipilimumab
neutrophil count
interleukin-2
  • 27 views
  • 03 Mar, 2021
  • 1 location
Comparison of Systematic Surgery Versus Surveillance and Rescue Surgery in Operable Oesophageal Cancer With a Complete Clinical Response to Radiochemotherapy

> Step 2: Randomisation in patients with a complete clinical response: Arm A: Systematic surgery Arm B: Surveillance and rescue surgery in cases with resectable loco-regional recurrence

  • 15 views
  • 21 Jan, 2021
  • 18 locations
Phase I Evaluating the Combination of Ribociclib+Capecitabine in Locally Advanced/Metastatic Breast Cancer HER2 Negative

dose escalation part (n= up to 30) to evaluate the safety profile and pharmacokinetics and to define the MTD and RP2D to recommend in a phase II. STEP 2: an expansion cohort part to confirm

mammogram
HER2
capecitabine
advanced breast cancer
stage iv breast cancer
  • 0 views
  • 23 Jan, 2021
  • 2 locations
Stepped Care aiTBS 2 Depression Study (Ghent)

> STEP 2: To optimize treatment and reduce relapse following the iTBS treatment, in a stepped care approach, all patients then continue with cognitive control training (CCT) ten days later. This CCT

benzodiazepines
depressed mood
selective serotonin reuptake inhibitors
major depressive disorder
antipsychotics
  • 2 views
  • 21 Jan, 2021
  • 1 location
Implementation of Multidisciplinary Assessments for Geriatric Patients in an ED Observation Unit

placed in an ED Observation Unit for (step 2) multidisciplinary geriatric assessment. Using an ED Observation Unit for these extended assessments overcomes the barriers to multidisciplinary geriatric

  • 0 views
  • 25 Feb, 2021
  • 1 location
Long-Acting Cabotegravir Plus VRC-HIVMAB075-00-AB (VRC07-523LS) for Viral Suppression in Adults Living With HIV-1

The purpose of this study is to assess the safety, tolerability, pharmacokinetics, and antiviral activity of long-acting cabotegravir (CAB LA) plus the broadly neutralizing monoclonal antibody,VRC-HIVMAB075-00-AB (VRC07-523LS), in adults living with HIV-1 with suppressed plasma viremia.

HIV Vaccine
reverse transcriptase inhibitor
hiv-1 antigen
local anesthetic
integrase inhibitors
  • 108 views
  • 13 Feb, 2021
  • 22 locations
Low-Dose Radiotherapy For Patients With SARS-COV-2 (COVID-19) Pneumonia

Low doses of radiation in the form of chest x-rays has been in the past to treat people with pneumonia. This treatment was thought to reduce inflammation and was found to be effective without side effects. However, it was an expensive treatment and was eventually replaced with less expensive treatment …

fever
dyspnea
SARS
x-rays
cough
  • 15 views
  • 25 Jan, 2021
  • 7 locations