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Found 73 clinical trials
Pre-Test Genetic Education and Remote Genetic Counseling in Communicating Tumor Profiling Results to Patients With Advanced Cancer

This research trial studies how well pre-test genetic education and remote genetic counseling works in communicating tumor profiling results to patients with advanced cancer. Web-based genetic education before receiving tumor profiling results and remote genetic counseling for patients with potential germline mutations may increase genetic knowledge and reduce distress for …

advanced cancer
cancer
  • 3 views
  • 26 Jan, 2021
  • 1 location
Recurrent Stroke Prevention Clinical Outcome Study

Objectives and Hypothesis Objectives: This study evaluates whether strict BP management is useful for the prevention of recurrent stroke. Hypertensive patients with history of stroke are treated with stepwise multi-drug therapy to achieve stricter BP target <120/80 mmHg in the strict BP control group and less stricter BP target <140/90 …

losartan
recurrent strokes
calcium
diuretics
blood pressure diastolic
  • 5 views
  • 08 Nov, 2020
  • 1 location
A Study to Determine If a New Shigella Vaccine is Safe Induces Immunity and The Best Dose Among Kenyan Infants

In this study, the tetravalent bioconjugate candidate vaccine Shigella4V will be tested to obtain first-in-human data on its safety and immunogenicity in infants and to identify the preferred dose of Shigella4V in 9 month old infants.

  • 0 views
  • 29 Jan, 2021
  • 2 locations
Testing the Addition of an Antibody to Standard Chemoradiation Followed by the Antibody for One Year to Standard Chemoradiation Followed by One Year of the Antibody in Patients With Unresectable Stage III Non-Small Cell Lung Cancer

This phase III trial studies how well an antibody (durvalumab) with chemotherapy and radiation therapy (chemoradiation) works in treating patients with stage III non-small cell lung cancer that cannot be removed by surgery (unresectable). Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer, …

nitrosoureas
tubal ligation
tumor cells
monoclonal antibodies
monoclonal antibody therapy
  • 136 views
  • 24 Feb, 2021
  • 536 locations
Scaling-Up Stepped Care for Women's Mental Health in Primary Care in an LMIC

This study examines: 1) short-term and longitudinal impacts of stepped care on women with depression and the possible roles of mediators and moderators; 2) clinic- (readiness to adopt an innovation, leadership support and climate) and provider-level (preparedness, motivation and fidelity) factors that may affect stepped care implementation; and 3) the …

  • 0 views
  • 03 Feb, 2021
  • 6 locations
Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial)

This ALCHEMIST trial studies genetic testing in screening patients with stage IB-IIIA non-small cell lung cancer that has been or will be removed by surgery. Studying the genes in a patient's tumor cells may help doctors select the best treatment for patients that have certain genetic changes.

tumor cells
erlotinib
paclitaxel
pembrolizumab
pemetrexed
  • 1103 views
  • 28 Feb, 2021
  • 1111 locations
Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors Non-Hodgkin Lymphomas or Histiocytic Disorders (The Pediatric MATCH Screening Trial)

This Pediatric MATCH screening and multi-sub-study phase II trial studies how well treatment that is directed by genetic testing works in pediatric patients with solid tumors, non-Hodgkin lymphomas, or histiocytic disorders that have progressed following at least one line of standard systemic therapy and/or for which no standard treatment exists …

bone marrow procedure
cns metastases
central nervous system tumor
alpha-fetoprotein
antibody therapy
  • 990 views
  • 28 Feb, 2021
  • 113 locations
Project to Improve Communication About Serious Illness--Hospital Study: Pragmatic Trial (Trial 1)

The objective of this protocol is to test the effectiveness of a Jumpstart intervention on patient-centered outcomes for patients with chronic illness by ensuring that they receive care that is concordant with their goals over time, and across settings and providers. This study will examine the effect of the EHR-based …

diabetes
vascular disease
acute illness
coronary artery disease
renal failure
  • 122 views
  • 25 Jan, 2021
  • 3 locations
As-needed Budesonide/Formoterol Turbuhaler in Stepping Down Period

maintenance therapy in step-2 management in asthma guildeline which is low dose inhaled corticosteroid.

bronchodilator
montelukast
formoterol
spirometry
corticosteroids
  • 1 views
  • 23 Jan, 2021
  • 1 location
Feasibility & Efficacy of Durvalumab+Tremelimumab+RT and Durvalumab+RT in Non-resect. Locally Advanced HPVnegativ HNSCC

if they can further proceed to patient randomization. Step 2 is Randomization of all eligible patients with a centrally diagnosed, HPV negative tumor in one of the two arms (Durvalumab plus

durvalumab
metastasis
  • 1 views
  • 22 Jan, 2021
  • 2 locations