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Found 68 clinical trials
MEN1611 With Cetuximab in Metastatic Colorectal Cancer (C-PRECISE-01) (C-PRECISE-01)

Open-label, dose-confirmation and cohort expansion, multicentre, Phase Ib/II study to assess the anti-tumour activity and safety of MEN1611 in combination with cetuximab for the treatment of patients with PIK3CA mutated metastatic colorectal cancer.

PIK3CA
fluorouracil
cetuximab
adenocarcinoma of colon
oxaliplatin
  • 19 views
  • 24 Mar, 2022
  • 24 locations
Comparing the Stanford Letter Project Form to Traditional Advance Directives (SLP)

Our goal is to compare two types of advance directives forms available in English and Spanish to determine which is more easy to use for patients.

Accepts healthy volunteers
  • 0 views
  • 23 Feb, 2022
  • 1 location
A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Moderate to Severe Upper Facial Lines (LANTIC)

with moderate to severe Glabellar Lines (GL) Step 2 (Phase II): dose finding step in participants with moderate to severe GL Stage 2 (phase II) An evaluation of

  • 0 views
  • 28 Apr, 2022
  • 1 location
Stepped Care for Youth at Risk of Psychosis

The study will recruit 60 young people who meet established criteria for being at clinical high risk for psychosis. They will be offered a range of psychological interventions starting with the most benign treatments in different steps. At step 1 they will be offered individual or group support and if …

  • 0 views
  • 08 Jun, 2022
  • 1 location
HYPOCHOL : A Genetically-based Strategy to Identify New Targets in Cholesterol Metabolism (HYPOCHOL)

The aim of this study is to identify new targets in cholesterol metabolism thanks to a genetically-based strategy.

  • 0 views
  • 24 Feb, 2022
  • 1 location
The Swedish Essential Tremor (SWEET) Trial (SWEET)

To evaluate the effect of deep brain stimulation (DBS) vs best medical treatment in essential tremor (ET) in a randomized, single-blinded controlled trial.

movement disorder
brain stimulation
  • 70 views
  • 05 Jun, 2022
  • 5 locations
RESPOND: Improving the Preparedness of Health Systems to Reduce Mental Health and Psychosocial Concerns Resulting From the COVID-19 Pandemic (RESPOND)

This randomized controlled trial will evaluate the implementation and (cost-)effectiveness of the culturally and contextually adapted Doing What Matters in times of stress (DWM) and Problem Management Plus (PM+) stepped-care programs amongst asylum seekers, refugees, and/or migrants living in Italy. Outcomes include mental health, resilience, wellbeing, health inequalities, and costs …

  • 0 views
  • 22 Mar, 2022
  • 1 location
Addressing Drug Use Stigma in Human Immunodeficiency Virus (HIV) Care and Treatment Clinics in Tanzania

The goal of this study is to adapt and pilot an effective health facility HIV stigma-reduction intervention to address drug use stigma in HIV Care and Treatment clinics (CTCs) in Tanzania, a barrier to linkage and retention in HIV care for People Living with HIV (PLWH) who use drugs. In …

Accepts healthy volunteers
  • 0 views
  • 26 Apr, 2022
  • 7 locations
S1803, Lenalidomide +/- Daratumumab/rHuPh20 as Post-ASCT Maintenance for MM w/MRD to Direct Therapy Duration (DRAMMATIC)

Patients are enrolled to screening (Reg Step 1) prior to or after ASCT but prior to Reg Step 2. Patients are followed until they will begin Maintenance and then registered to Reg Step 2 (first

aspirin
lenalidomide
warfarin
heparin
daratumumab
  • 216 views
  • 04 Mar, 2022
  • 543 locations
Surveillance and Treatment to Prevent Fetal Atrioventricular Block Likely to Occur Quickly (STOP BLOQ)

reduces the need for weekly echoes. Although mothers with low titer anti-Ro will not be continued in Step 2 and therefore not followed by FHRM, birth ECGs will be collected to confirm that low titer

  • 42 views
  • 25 Mar, 2022
  • 1 location