step 2 Clinical Research Trials

Very Early Intensive Treatment of HIV-Infected Infants to Achieve HIV Remission

The study will explore the effects of early intensive antiretroviral therapy (ART) on achieving HIV remission (HIV RNA below the limit of detection of the assay) among HIV-infected infants.

lopinavir/ritonavir

antibody test

enzyme-linked immunosorbent assay

reverse transcriptase inhibitor

raltegravir

94 views
10 Nov, 2019
49 locations

MEN1611 With Cetuximab in Metastatic Colorectal Cancer (C-PRECISE-01)

Open-label, dose-confirmation and cohort expansion, multicentre, Phase Ib/II study to assess the anti-tumour activity and safety of MEN1611 in combination with cetuximab for the treatment of patients with PIK3CA mutated metastatic colorectal cancer.

oxaliplatin

adenocarcinoma

cetuximab

adenocarcinoma of colon

PIK3CA

2 views
15 Dec, 2020
39 locations

Comparing the Stanford Letter Project Form to Traditional Advance Directives

Our goal is to compare two types of advance directives forms available in English and Spanish to determine which is more easy to use for patients.

0 views
22 Mar, 2020
1 location

Feasibility & Efficacy of Durvalumab+Tremelimumab+RT and Durvalumab+RT in Non-resect. Locally Advanced HPVnegativ HNSCC

if they can further proceed to patient randomization. Step 2 is Randomization of all eligible patients with a centrally diagnosed, HPV negative tumor in one of the two arms (Durvalumab plus

metastasis

durvalumab

1 views
08 Nov, 2020
1 location

Phase I Evaluating the Combination of Ribociclib+Capecitabine in Locally Advanced/Metastatic Breast Cancer HER2 Negative

: a dose escalation part (n= up to 30) to evaluate the safety profile and pharmacokinetics and to define the MTD and RP2D to recommend in a phase II. STEP 2: an expansion cohort part to

erbb2

capecitabine

stage iv breast cancer

chromogenic in situ hybridization

taxane

0 views
08 Nov, 2020
1 location

MIRs 04 : Interpectoral Nerve Block With Ropivacaine Versus Placebo Before Breast Cancer Surgery

Compare the effect of ropivacaine versus placebo pectoral nerve block (Pecs 1 and 2) on acute pain after tumorectomy plus sentinel lymph node dissection on one day surgery.

breast carcinoma

invasive breast cancer

carcinoma

sentinel node

breast-conserving surgery

0 views
23 Sep, 2020
3 locations

High Dosage Buprenorphine as a Drug Strategy Withdrawal Assistance of Analgesics Opioid

The prevalence of analgesics opioids addiction in chronic pain patient is very difficult to know. Many studies indicated that the prevalence of addiction varied from 0% up to 50% in chronic non cancer pain patients, and from 0% up to 7.7% in cancer pain patients. Analgesics opioids use have increasingly …

1 views
08 Nov, 2020

Pharmacogenetics Use For Further Treatment Improvement in childreN

There is large heterogeneity in treatment response to asthma medication and a one-size fits all approach based on current guidelines might not fit all children with asthma. It is expected that children with one or more variant alleles (Arg16Arg and Arg16Gly) within the beta2 adrenergic receptor (ADRB2) gene coding for …

6 views
19 Jan, 2020
20 locations

R2-MTX With Lenalidomide Maintenance in Newly-diagnosed PCNSL a Multicenter Phase Ib/II Stuty

This is a multicenter prospective single arm phase Ib/II study, and the purpose of this study is to evaluate the safety and efficiency of R2-MTX regimen (rituximab & lenalidomide & methotrexate) combined with lenalidomide maintenance in newly-diagnosed primary central nervous system lymphoma. 2-year Progression free survival (PFS) of the cohort …

lenalidomide

methotrexate

rituximab

nervous

0 views
10 Jun, 2020
1 location

HYPOCHOL : A Genetically-based Strategy to Identify New Targets in Cholesterol Metabolism

The aim of this study is to identify new targets in cholesterol metabolism thanks to a genetically-based strategy.

0 views
23 Dec, 2019
1 location

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Found 76 clinical trials