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Found 71 clinical trials
MEN1611 With Cetuximab in Metastatic Colorectal Cancer (C-PRECISE-01) (C-PRECISE-01)

Open-label, dose-confirmation and cohort expansion, multicentre, Phase Ib/II study to assess the anti-tumour activity and safety of MEN1611 in combination with cetuximab for the treatment of patients with PIK3CA mutated metastatic colorectal cancer.

  • 24 Mar, 2022
  • 24 locations
Comparing the Stanford Letter Project Form to Traditional Advance Directives (SLP)

Our goal is to compare two types of advance directives forms available in English and Spanish to determine which is more easy to use for patients.

Accepts healthy volunteers
  • 23 Feb, 2022
  • 1 location
A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Moderate to Severe Upper Facial Lines (LANTIC)

448 participants. The protocol is currently approved up to stage 1, step 1 and stage 1/ step 2. Stage 1 (phase Ib & II) Step 1 (Phase Ib): a dose-escalation first-in-human

  • 08 Aug, 2022
  • 1 location
Improving HIV Outcomes Among African American Transgender Women

(Step 1: assigned male birth sex, Step 2: current gender identity is female); 2) be aged 18 or older; 3) report risk of HIV transmission in past 3 months (i.e., CAS with a serodiscordant or risky

Accepts healthy volunteers
  • 10 Aug, 2022
Stepped Care for Youth at Risk of Psychosis

The study will recruit 60 young people who meet established criteria for being at clinical high risk for psychosis. They will be offered a range of psychological interventions starting with the most benign treatments in different steps. At step 1 they will be offered individual or group support and if …

  • 08 Jun, 2022
  • 1 location
Culturally Centering Medications for Opioid Use Disorder With American Indian and Alaska Native Communities (CTN-0096)

This is a formative research study to test a culturally-centered, program-level implementation intervention to increase the use of medications for opioid use disorder in four healthcare and addiction specialty treatment sites serving American Indian and Alaska Native communities.

  • 25 Jul, 2022
  • 1 location
HYPOCHOL : A Genetically-based Strategy to Identify New Targets in Cholesterol Metabolism (HYPOCHOL)

The aim of this study is to identify new targets in cholesterol metabolism thanks to a genetically-based strategy.

  • 24 Feb, 2022
  • 1 location
The Swedish Essential Tremor (SWEET) Trial (SWEET)

To evaluate the effect of deep brain stimulation (DBS) vs best medical treatment in essential tremor (ET) in a randomized, single-blinded controlled trial.

brain stimulation
movement disorder
  • 05 Jun, 2022
  • 5 locations
RESPOND: Improving the Preparedness of Health Systems to Reduce Mental Health and Psychosocial Concerns Resulting From the COVID-19 Pandemic (RESPOND)

This randomized controlled trial will evaluate the implementation and (cost-)effectiveness of the culturally and contextually adapted Doing What Matters in times of stress (DWM) and Problem Management Plus (PM+) stepped-care programs amongst asylum seekers, refugees, and/or migrants living in Italy. Outcomes include mental health, resilience, wellbeing, health inequalities, and costs …

  • 22 Mar, 2022
  • 1 location
Addressing Drug Use Stigma in Human Immunodeficiency Virus (HIV) Care and Treatment Clinics in Tanzania

The goal of this study is to adapt and pilot an effective health facility HIV stigma-reduction intervention to address drug use stigma in HIV Care and Treatment clinics (CTCs) in Tanzania, a barrier to linkage and retention in HIV care for People Living with HIV (PLWH) who use drugs. In …

Accepts healthy volunteers
  • 26 Apr, 2022
  • 7 locations