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Found 76 clinical trials
Very Early Intensive Treatment of HIV-Infected Infants to Achieve HIV Remission

The study will explore the effects of early intensive antiretroviral therapy (ART) on achieving HIV remission (HIV RNA below the limit of detection of the assay) among HIV-infected infants.

lopinavir/ritonavir
antibody test
enzyme-linked immunosorbent assay
reverse transcriptase inhibitor
raltegravir
  • 94 views
  • 10 Nov, 2019
  • 49 locations
MEN1611 With Cetuximab in Metastatic Colorectal Cancer (C-PRECISE-01)

Open-label, dose-confirmation and cohort expansion, multicentre, Phase Ib/II study to assess the anti-tumour activity and safety of MEN1611 in combination with cetuximab for the treatment of patients with PIK3CA mutated metastatic colorectal cancer.

oxaliplatin
adenocarcinoma
cetuximab
adenocarcinoma of colon
PIK3CA
  • 2 views
  • 15 Dec, 2020
  • 39 locations
Comparing the Stanford Letter Project Form to Traditional Advance Directives

Our goal is to compare two types of advance directives forms available in English and Spanish to determine which is more easy to use for patients.

  • 0 views
  • 22 Mar, 2020
  • 1 location
Feasibility & Efficacy of Durvalumab+Tremelimumab+RT and Durvalumab+RT in Non-resect. Locally Advanced HPVnegativ HNSCC

if they can further proceed to patient randomization. Step 2 is Randomization of all eligible patients with a centrally diagnosed, HPV negative tumor in one of the two arms (Durvalumab plus

metastasis
durvalumab
  • 1 views
  • 08 Nov, 2020
  • 1 location
Phase I Evaluating the Combination of Ribociclib+Capecitabine in Locally Advanced/Metastatic Breast Cancer HER2 Negative

: a dose escalation part (n= up to 30) to evaluate the safety profile and pharmacokinetics and to define the MTD and RP2D to recommend in a phase II. STEP 2: an expansion cohort part to

erbb2
capecitabine
stage iv breast cancer
chromogenic in situ hybridization
taxane
  • 0 views
  • 08 Nov, 2020
  • 1 location
MIRs 04 : Interpectoral Nerve Block With Ropivacaine Versus Placebo Before Breast Cancer Surgery

Compare the effect of ropivacaine versus placebo pectoral nerve block (Pecs 1 and 2) on acute pain after tumorectomy plus sentinel lymph node dissection on one day surgery.

breast carcinoma
invasive breast cancer
carcinoma
sentinel node
breast-conserving surgery
  • 0 views
  • 23 Sep, 2020
  • 3 locations
High Dosage Buprenorphine as a Drug Strategy Withdrawal Assistance of Analgesics Opioid

The prevalence of analgesics opioids addiction in chronic pain patient is very difficult to know. Many studies indicated that the prevalence of addiction varied from 0% up to 50% in chronic non cancer pain patients, and from 0% up to 7.7% in cancer pain patients. Analgesics opioids use have increasingly …

  • 1 views
  • 08 Nov, 2020
Pharmacogenetics Use For Further Treatment Improvement in childreN

There is large heterogeneity in treatment response to asthma medication and a one-size fits all approach based on current guidelines might not fit all children with asthma. It is expected that children with one or more variant alleles (Arg16Arg and Arg16Gly) within the beta2 adrenergic receptor (ADRB2) gene coding for …

  • 6 views
  • 19 Jan, 2020
  • 20 locations
R2-MTX With Lenalidomide Maintenance in Newly-diagnosed PCNSL a Multicenter Phase Ib/II Stuty

This is a multicenter prospective single arm phase Ib/II study, and the purpose of this study is to evaluate the safety and efficiency of R2-MTX regimen (rituximab & lenalidomide & methotrexate) combined with lenalidomide maintenance in newly-diagnosed primary central nervous system lymphoma. 2-year Progression free survival (PFS) of the cohort …

lenalidomide
methotrexate
rituximab
nervous
  • 0 views
  • 10 Jun, 2020
  • 1 location
HYPOCHOL : A Genetically-based Strategy to Identify New Targets in Cholesterol Metabolism

The aim of this study is to identify new targets in cholesterol metabolism thanks to a genetically-based strategy.

  • 0 views
  • 23 Dec, 2019
  • 1 location