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Found 29 clinical trials
A Study of Melphalan, BCNU, Vitamin B12b, Vitamin C, and Stem Cell Infusion in People With Advanced Pancreatic Cancer and BRCA Mutations

autologous hematopoietic stem cell infusion. A dose-escalation schedule will be employed for vitamin C

BRCA2
BRCA1
cancer chemotherapy
  • 14 views
  • 08 Jun, 2022
  • 2 locations
A Research Study of Bone Marrow Transplantation From Unrelated or Partially Matched Related Donors

It is hypothesized that engraftment when administering cyclophosphamide post the stem cell infusion will increase, the incidence of graft versus host disease (GVHD) and day 100 mortality will

acute leukemia
tacrolimus
fludarabine
chronic myelomonocytic leukemia
total body irradiation
  • 20 views
  • 24 Mar, 2022
  • 1 location
Evaluate the Safety and Explore Efficacy of Umbilical Cord Mesenchymal Stem Cells in Acute Ischemic Stroke

, use of appropriate dose and concentration of stem cells, standardized techniques of stem cell infusion, and intensive patient monitoring during and after stem cell infusion.

ischemic stroke
  • 4 views
  • 06 Apr, 2022
  • 2 locations
Allo HSCT Using RIC for Hematological Diseases

This is a phase II trial using a non-myeloablative cyclophosphamide/ fludarabine/total body irradiation (TBI) preparative regimen followed by a related or unrelated donor stem cell infusion. The

tacrolimus
b-cell lymphoma
mold
hematologic disorder
stem cell transplantation
  • 27 views
  • 24 Feb, 2022
  • 1 location
Efficacy and Safety of Umbilical Cord Mesenchymal Stem Cells Transplantation in Patients With Type 2 Diabetes Mellitus

to observe the efficacy and safety of umbilical cord mesenchymal stem cell infusion therapy.

type 2 diabetes mellitus
insulin
antidiabetic agents
body mass index
hypoglycemic agents
  • 0 views
  • 24 Jan, 2021
  • 1 location
Depleted Donor Stem Cell Transplant in Children and Adults With Fanconi Anemia After Being Conditioned With a Regimen Containing JSP191

current standard of care method). Participants will be administered the conditioning regimen, are assessed until they receive the depleted stem cell infusion, and will be followed for up to 2 years

rabbit atg
chromosome breakage
fludarabine
neutrophil count
platelet count
  • 0 views
  • 21 Mar, 2022
  • 1 location
Study Using Prebiotics to Improve Gut Microbiome Diversity After Autologous Stem Cell Transplantation

subject's choice. The intervention will begin approximately 10 days prior to stem cell infusion and will continue until the first day of neutrophil engraftment (first day absolute neutrophil count >500

  • 0 views
  • 29 Apr, 2022
  • 1 location
Stem Cell Transplant in Patients With Severe Sickle Cell Disease

This is a prospective pilot study of matched-related donor allogeneic stem cell transplantation in adults with severe sickle cell disease using a matched-sibling PBSC graft with a non-myeloablative conditioning regimen (Alemtuzumab).

osteonecrosis
stroke
sirolimus
iron
iron overload
  • 31 views
  • 01 May, 2022
  • 1 location
Sorafenib Busulfan and Fludarabine in Treating Patients With Recurrent or Refractory Acute Myeloid Leukemia Undergoing Donor Stem Cell Transplant

This phase I/II trial studies the best dose of sorafenib when given together with busulfan and fludarabine in treating patients with acute myeloid leukemia that has come back or does not respond to treatment and who are undergoing donor stem cell transplant. Sorafenib may stop the growth of cancer cells …

cell transplantation
cancer
tacrolimus
filgrastim
fludarabine
  • 13 views
  • 24 Nov, 2021
  • 2 locations
Study of Intensity Modulated Total Marrow Irradiation (IM-TMI) in Addition to Fludarabine/Busulfan Conditioning for Allogeneic Transplantation in High Risk AML and Myelodysplastic Syndromes

The study is a Phase II clinical trial. Patients will receive intensity modulated total marrow irradiation (TMI) at a dose of 9 Gy with standard myeloablative fludarabine/ i.v. targeted busulfan (FluBu) conditioning prior to allogeneic hematopoietic stem cell transplant (HSCT).

secondary acute myeloid leukemia
antithymocyte globulin
methotrexate
tacrolimus
fludarabine
  • 6 views
  • 25 Feb, 2022
  • 1 location