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Found 121 clinical trials
A Study to Examine the Effects of the Leptin Receptor (LEPR) Agonist Antibody REGN4461 in Adult Patients With Familial Partial Lipodystrophy (FPLD) (LEAP)

set of Cohorts A plus B: To evaluate the effect of REGN4461 on liver fat in patients with hepatic steatosis To evaluate the effect of REGN4461 on hunger To evaluate

  • 0 views
  • 13 Apr, 2022
  • 2 locations
Effect of Dapagliflozin vs Sitagliptin on Liver Fat Accumulation and Body Composition in Patients With Diabetes Mellitus and Liver Transplantation (Dapa-LiT)

transplantation develop fatty liver (liver steatosis) several months after transplantation, which is a risk factor for liver dysfunction. SGLT-2 inhibitors are reported to have favorable effect on liver fat

oral hypoglycemic
sitagliptin
metformin
insulin
body mass index
  • 0 views
  • 24 Mar, 2022
  • 1 location
Moderately Carbohydrate-restricted Diet to Treat NAFLD in Adolescents

(n=80) will have been diagnosed with NAFLD based on the presence of current evidence of active disease, which will be determined by the ongoing presence of hepatic steatosis estimated by diffusely

hemoglobin a1c
insulin resistance
sugars
fatty liver
insulin
  • 0 views
  • 26 May, 2022
  • 1 location
Postprandial VLDL-triglyceride Metabolism in Type 2 Diabetes Patients With and Without NAFLD

Non-alcoholic fatty liver disease (NAFLD) covers a spectrum from simple reversible hepatic steatosis to inflammation and fibrosis termed steatohepatitis (NASH). The mechanisms behind why some

type 2 diabetes mellitus
insulin
sugars
cardiovascular disease
  • 0 views
  • 03 Jun, 2022
  • 1 location
Effect of a Physical Training Program on Cerebral Hemodynamics in Patients With Metabolic-associated Fatty Liver Disease (CERHEMAFLD)

improve alterations in cerebral blood flow, cognitive function, endothelial function, body composition, and the degree of liver steatosis and fibrosis. This outcome has never been assessed in MAFLD

  • 0 views
  • 19 Sep, 2022
  • 1 location
Alternation of Non-alcoholic Fatty Liver Disease (NAFLD) and Cardiovascular Risks After Liftestyle Modification: A Ultrasound Attenuation Imaging-Based Study

performed to measure tissue attenuation coefficient so as to evaluate liver steatosis and liver fibrosis stage. Meanwhile, magnetic resonance imaging (MRI) will be carried out, which include cardiovascular

  • 0 views
  • 26 May, 2022
  • 1 location
Neuroinflammation and Neurodegeneration in HIV-positive Subjects Switched and Initially Treated With INSTI

of steatosis and visceral fat thickness will be assessed using ultrasonography of abdomen. The primary imaging will be performed at the time of enrollment of patients, along with the

cholesterol level
antiretroviral therapy
HIV Vaccine
efavirenz
insulin
  • 0 views
  • 09 Dec, 2021
  • 1 location
Relationship Between the Development of Impaired Glucose Tolerance, the Phenotype of CFLD, and the Risk of Liver Fibrosis

This study proposes to examine the relationship between the development of impaired glucose tolerance, the phenotype of CFLD, and risk of liver fibrosis.

  • 0 views
  • 27 Apr, 2022
  • 1 location
Role of Lisinopril in Preventing the Progression of Non-Alcoholic Fatty Liver Disease, RELIEF-NAFLD Study

This phase II trial investigates how well lisinopril may work in preventing the progression of non-alcoholic fatty liver disease (NAFLD). NAFLD is a condition where there is an accumulation of fatty cells in the liver. NAFLD increases a person's risk of developing liver cancer. Liver fibrosis is the common finding …

neutrophil count
cancer
  • 0 views
  • 09 Jul, 2022
  • 3 locations
Hepatic Energy Fluxes in NASH and NAS Patients

Diseases along the nonalcoholic fatty liver disease spectrum, which are tightly coupled to the obesity epidemic, are soon to become the commonest indication for liver transplantation in the United States. Bariatric surgery shows great promise in the treatment of these diseases. The studies proposed herein will be the first to …

burn fat
glycosylated hemoglobin
sleeve gastrectomy
hemoglobin a1c
obesity
  • 250 views
  • 24 Mar, 2022
  • 1 location