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Found 120 clinical trials
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The study will evaluate the effect of coadministration of a range of doses of DGAT2i with 1 dose of ACCi, on hepatic steatosis and the ability of DGAT2i to mitigate ACCi-induced elevations in

  • 10 Jan, 2022
  • 3 locations
The Effect of Aerobic and Resistant Exercise Training in Patients With Non-Alcoholic Steatohepatitis

The term non-alcoholic fatty liver disease (NAFLD) is used to describe a range of chronic liver diseases that range from steatosis to steatohepatitis, advanced fibrosis, cirrhosis, or excessive

  • 04 Oct, 2022
  • 1 location
Study of Immune Response and Liver Damage Induced by Chemotherapy for Liver Metastases of Colorectal Cancer

before hepatectomy. Steatosis is frequently observed after administration of 5-FU alone or in combination with irinotecan. This steatosis may also be accompanied by inflammatory lesions (steatohepatitis

  • 09 Oct, 2021
  • 1 location
Pathophysiology of Uric Acid Nephrolithiasis (IUAN)

This study has two aims: Aim 1: To determine the presence of accumulation of fat within cells and the functional consequences of this in the kidney by correlating kidney fat content with urine test results. Aim 2: The investigators will evaluate the effect of thiazolidinedione (pioglitazone) on excess fatty acid …

  • 24 Jan, 2022
  • 1 location
Lifestyle Modification for MAFLD Based on TTM

Lifestyle changes aiming at weight loss remain the cornerstone of MAFLD treatment.Evaluating the motivational stage of patients' change and providing targeted lifestyle guidance may significantly improve the efficiency of weight loss. The investigators hypothesize that gut microbiota may affect motivation to lose weight, and the changes in gut microbiota due …

  • 13 May, 2021
  • 1 location
Indocyanine Green Clearance Test in Liver Transplantation (LivInG) (LivInG)

The gap between patients awaiting and those undergoing liver transplantation (LT) continues to grow. Marginal organs carry higher risk of failure after LT however they are increasingly used to fill such gap. Viability assessment of the graft is essential to lower the risk of LT failure and need for emergency …

  • 10 Mar, 2022
  • 1 location
Young Adults With Early-onset Obesity Treated With Semaglutide -The RESETTLE Study (RESETTLE)

Introduction: Obesity prevalence is particularly pronounced among adolescents. Currently available treatment options consists of structured lifestyle interventions. However, 25 % of adolescents do not respond to lifestyle treatment, why new effective treatment strategies are needed. Therefore, the aim of this study is to investigate the effect of lifestyle interventions combined …

Accepts healthy volunteers
  • 22 Oct, 2022
  • 1 location
NAFLD Primary Care

simple steatosis, however in about 15-30% non-alcoholic steatohepatitis (NASH) develops, which leads to an overall increase in morbidity and mortality due to the progression to fibrosis, cirrhosis and

type 2 diabetes mellitus
fatty liver
liver disease
  • 23 Jun, 2021
  • 1 location
May the Risk of PHLF be Predicted With Preoperative Liver Gadoxetate MRI

Post hepatectomy liver failure (PHLF) is one of the most severe complications after liver re-section. Preoperative evaluation of liver function is complicated and imprecise. The volume and function needed for each individual patient is unknown and the methods used for evaluation are uncertain. Preoperative MRI with Gadolinium may give dynamic …

  • 26 Jan, 2021
  • 7 locations
Sex Differences in Myocardial Steatosis Induced Left Ventricular Dysfunction

MRI will take approximately 90-120 minutes. Aim 1 will test the hypothesis that cardiac steatosis induced left ventricular dysfunction is sexually dimorphic, by comparing age-matched men and

  • 03 Feb, 2021
  • 1 location