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Found 93 clinical trials
Identification and Validation of Noninvasive Biomarkers of the Diagnosis and Severity of NASH in Type 2 Diabetics

Metabolic diseases of the liver are silent affections whose morbidity is important. About 70% of patients with type 2 diabetes (T2D) are concerned. Of these, 50% develop clinically significant lesions (including non-alcoholic steatohepatitis or NASH) as they are associated with an increased risk of complications; and 15% progress to severe …

  • 0 views
  • 24 Jan, 2021
  • 2 locations
Phase 2 Study of Obeticholic Acid for Lipodystrophy Patients

Lipodystrophies are rare disorders characterized by selective loss of adipose tissue and predisposition to insulin resistance and its metabolic complications. Hepatic steatosis is a common

  • 2 views
  • 22 Nov, 2020
  • 2 locations
Validation of the Second Generation of the Controlled Attenuation Parameter (CAP) Using the MRI-PDFF as Reference

). Even if the liver fibrosis is the key pathological feature of progressive liver disease, the accumulation of excessive hepatic triglyceride, hepatic steatosis, is today recognized as an

steatosis
diabetes
fibrosis
fatty liver
hepatic fibrosis
  • 0 views
  • 03 Jun, 2020
  • 6 locations
Study of Immune Response and Liver Damage Induced by Chemotherapy for Liver Metastases of Colorectal Cancer

before hepatectomy. Steatosis is frequently observed after administration of 5-FU alone or in combination with irinotecan. This steatosis may also be accompanied by inflammatory lesions (steatohepatitis

  • 0 views
  • 24 Jan, 2021
  • 1 location
Anaplerotic Therapy Using Triheptanoin for Patients With Glycogen Storage Disease Type I

; and the prevention of increased liver steatosis based on ultrasound with elastography.

  • 33 views
  • 19 Nov, 2020
  • 1 location
Assessment of the Correlation Between Serum Levels of Adropin and Degree of Severity of Chronic Liver Disease

significantly exacerbated hepatic steatosis, inflammatory responses and fibrosis in mice. Furthermore, the treatment with Adropin bioactive peptides slowed NASH progression in mice. In search for a good

  • 0 views
  • 17 Dec, 2020
  • 1 location
Metformin in Patients With Non-Alcoholic Fatty Liver Disease (NAFLD)

The purpose of this study is to examine the effect of metformin on biochemical and histological findings in NAFLD patients with insulin resistance syndrome.

diabetes
fatty liver
insulin
  • 8 views
  • 07 Nov, 2020
  • 1 location
Fatty Liver and Ectopic Fat in Overweight and Obese Patients

The aim of the study is to find new clinico-biological and medical imaging parameters associated with non alcoholic steatohepatitis in overweight and obese patients.

  • 2 views
  • 07 Nov, 2020
  • 1 location
Pathophysiology of Uric Acid Nephrolithiasis

This study has two aims: Aim 1: To determine the presence of accumulation of fat within cells and the functional consequences of this in the kidney by correlating kidney fat content with urine test results. Aim 2: The investigators will evaluate the effect of thiazolidinedione (pioglitazone) on excess fatty acid …

  • 8 views
  • 24 Jan, 2021
  • 1 location
May the Risk of PHLF be Predicted With Preoperative Liver Gadoxetate MRI

Post hepatectomy liver failure (PHLF) is one of the most severe complications after liver re-section. Preoperative evaluation of liver function is complicated and imprecise. The volume and function needed for each individual patient is unknown and the methods used for evaluation are uncertain. Preoperative MRI with Gadolinium may give dynamic …

  • 0 views
  • 09 Jan, 2021
  • 7 locations