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Found 47 clinical trials
Featured trial
CT COMPARE: CT COronary Angiography to Measure PlAque REduction

The study is investigating how the amount of plaque in your arteries can be reduced by statin medication. Researchers at the National Institutes of Health (NIH) Clinical Center in Bethesda, Maryland, are looking for volunteers to participate in a 36-month study. There are no costs for study-related tests, procedures or medication. For …

hmg-coa reductase inhibitors
statin therapy
hyperlipidemia
  • 365 views
  • 22 Dec, 2020
  • 1 location
Featured trial
A randomized, double-blind, placebo-controlled multicenter trial, assessing the impact of inclisiran on major adverse cardiovascular events in participants with established cardiovascular disease

lining of an artery).This study is designed to evaluate the treatment of an investigational medication along with a well-tolerated statin therapy (lipid lowering medication). The goal is to help reduce the

stroke
atherosclerotic cardiovascular disease
hmg-coa reductase inhibitor
  • 0 views
  • 29 Apr, 2022
  • 1 location
Featured trial
FOURIER - Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk

FOURIER - Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk

  • 268 views
  • 25 Mar, 2021
  • 1 location
Study of Inclisiran to Prevent Cardiovascular (CV) Events in Participants With Established Cardiovascular Disease (VICTORION-2P)

Study CKJX839B12302 is a pivotal Phase III trial to evaluate the benefits of inclisiran on major adverse cardiovascular (MACE) events in participants with established cardiovascular disease (CVD).

  • 0 views
  • 09 May, 2022
  • 319 locations
STREAM Trial - Statins in Multimorbid Older Adults Without Cardiovascular Disease (STREAM)

Statins are among the most widely used drugs. While they were found to be effective for primary and secondary prevention of cardiovascular disease (CVD) in middle-aged subjects, their benefits for primary prevention in older adults (aged ≥70 years) without CVD are uncertain, particularly for those with multimorbidity. The aim of …

  • 0 views
  • 24 Mar, 2022
Dark Adaptation as an Early Indicator of Response to Statin Therapy for Intermediate AMD

interventional trial for off label use of high dose atorvastatin 80 mg in intermediate AMD patients and correlate recovery response measured by dark adaptation recovery time with drusen volume reduction measured by SD-OCT

spectral domain optical coherence tomography
drusen
  • 0 views
  • 22 Oct, 2021
  • 1 location
A Randomized Study to Evaluate the Effect of an "Inclisiran First" Implementation Strategy Compared to Usual Care in Patients With Atherosclerotic Cardiovascular Disease and Elevated LDL-C Despite Receiving Maximally Tolerated Statin Therapy (VICTORION-INITIATE) (V-INITIATE)

The purpose of this study is to assess the effectiveness of an "inclisiran first" implementation strategy (addition of inclisiran to maximally tolerated statin therapy immediately upon failure

  • 11 views
  • 26 Apr, 2022
  • 23 locations
Citrulline Efficacy to Improve Carbohydrate Metabolism Abnormalities in the Patient Treated With High Doses of Statin (STATIMPROVE)

prevention of cardiovascular disease. However, long-term statin therapy is associated with impaired carbohydrate metabolism and increased risk of developing type 2 diabetes (T2D), particularly in patients

  • 23 views
  • 13 Apr, 2022
  • 1 location
Colchicine/Statins for the Prevention of COVID-19 Complications (COLSTAT) Trial

This is a pragmatic randomized open-label study of the safety and efficacy of the combination of colchicine and Rosuvastatin in addition to standard of care (SOC) compared to SOC alone in hospitalized patients with SARS-CoV-2

  • 0 views
  • 12 Mar, 2021
  • 4 locations
A Clinical Trial of STAtin Therapy for Reducing Events in the Elderly (STAREE)

The STAREE study will examine whether treatment with statin (atorvastatin 40mg) compared with placebo will prolong overall survival or disability free survival amongst healthy elderly people (70 years).

  • 0 views
  • 23 Jan, 2021
  • 4 locations