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Found 58 clinical trials
Dexamethasone Effects in Patients With Refractory Non-Small Cell Lung Cancer Using FLT Positron Emission Tomography

This pilot research trial studies the effects of dexamethasone in patients with non-small cell lung cancer that has not responded after previous treatment. Drugs such as dexamethasone can affect how tumors grow and respond to treatments. Imaging tests, such as fluoro-L-thymidine (FLT) positron emission tomography , use a small amount …

biomarker analysis
lung cancer
diabetes
corticosteroids
neutrophil count
  • 12 views
  • 27 Apr, 2022
  • 1 location
A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer

This is a study to investigate the efficacy and safety of an infusion of IOV-4001 in adult participants with unresectable or metastatic melanoma or advanced non-small-cell lung cancer (NSCLC).

  • 0 views
  • 14 Jun, 2022
  • 1 location
Testing the Effects of MK-3475 (Pembrolizumab) With or Without the Usual Chemotherapy Treatment for Patients 70 Years of Age and Older With Advanced Non-small Cell Lung Cancer

This trial studies the side effects of pembrolizumab with or without chemotherapy in treating patients with stage IV non-small cell lung cancer that has come back (recurrent) and has spread to

  • 0 views
  • 06 May, 2022
  • 441 locations
Poziotinib in EGFR Exon 20 Mutant Advanced NSCLC

This phase II trial studies how well poziotinib works in treating patients with non-small lung cancer with an EGFR or HER2 exon 20 mutation that is stage IV or has come back (recurrent). Poziotinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell …

measurable disease
lung cancer
metastasis
hysterectomy
systemic therapy
  • 1904 views
  • 28 Jan, 2022
  • 1 location
NBTXR3 Activated by Radiotherapy for Patients With Advanced Cancers Treated With An Anti-PD-1 Therapy

The 1100 study is an open-label, Phase I, dose escalation and expansion prospective clinical study to assess the safety of intratumoral injection of NBTXR3 activated by radiotherapy in combination with anti-PD-1 therapy.

cancer
nbtxr3
  • 13 views
  • 28 Jun, 2022
  • 6 locations
Ceritinib and Everolimus in Treating Patients With Locally Advanced or Metastatic Solid Tumors or Stage IIIB-IV Non-small Cell Lung Cancer

This phase I trial studies the side effects and best dose of ceritinib and everolimus in treating patients with solid tumors that have spread from where they started to nearby tissue or lymph nodes (locally advanced) or to other places in the body (metastatic) or stage IIIB-IV non-small cell lung …

measurable disease
lung cancer
metastasis
biomarker analysis
prothrombin
  • 193 views
  • 24 Jan, 2022
  • 1 location
Improving Patient and Caregiver Understanding of Risks and Benefits of Immunotherapy for Lung Cancer or Melanoma

The purpose of this study is to refine and pilot test educational material developed to educate and support patients receiving immunotherapy for advanced lung cancer or melanoma. The intervention is an educational video and question prompt list (QPL) to promote communication between patients, caregivers, and the oncology team about the …

  • 0 views
  • 07 Aug, 2021
  • 1 location
Ceritinib Plus Docetaxel in ALK-Negative, EGFR WT Advanced NSCLC

The main purpose of this study is to find out what effects (good and bad) ceritinib (Zykadia®) used in combination with docetaxel (Taxotere®) will have on participants and their cancer. The results will help to determine the best safe dose of the combination of the medications Ceritinib (Zykadia®) and docetaxel …

corticosteroids
lung cancer
metastasis
brain metastases
EGFR
  • 8 views
  • 13 May, 2022
  • 2 locations
Atezolizumab and Cobimetinib in Treating Patients With Metastatic, Recurrent, or Refractory Non-small Cell Lung Cancer

This phase II trial studies how well atezolizumab and cobimetinib work in treating patients with non-small cell lung cancer that has spread to other places in the body (metastatic), has come back (recurrent), or does not respond to treatment (refractory). Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the …

measurable disease
lung cancer
metastasis
serum bilirubin level
neutrophil count
  • 54 views
  • 14 Jun, 2022
  • 7 locations
Sirolimus and Auranofin in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer or Small Cell Lung Cancer

This phase I/II trial studies the side effects and best dose of auranofin when given together with sirolimus and to see how well it works in treating patients with lung cancer that has spread or other places in the body and cannot be cured or controlled by treatment or has …

biomarker analysis
lung cancer
serum pregnancy test
recurrent non-small cell lung cancer
direct bilirubin
  • 16 views
  • 30 Nov, 2021
  • 2 locations