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Found 369 clinical trials
Paclitaxel Therapeutic Drug Monitoring in Cancer Patients

The goals of this prospective, observational cohort study are to determine the feasibility of implementing paclitaxel therapeutic drug monitoring for cancer patients and explore the relationship between paclitaxel drug exposure and the development of neuropathic symptoms. This trial studies if paclitaxel can be consistently measured in the blood of patients …

metastasis
carboplatin
bevacizumab
invasive breast cancer
neuropathy
  • 0 views
  • 07 Apr, 2021
  • 1 location
Immune Response to Anti-HER2 Therapies in Patients With HER2-Positive Stage I-IV Breast Cancer

This study gathers information from the blood cells and tumor tissue during treatment with anti-HER2 therapies, such as trastuzumab, pertuzumab, lapatinib, or neratinib, in patients with HER2 positive stage I-IV breast cancer who are scheduled to start anti-HER2 therapy. The information gained from this study may help researchers better understand …

gene amplification
neratinib
estrogen
progesterone receptor
trastuzumab
  • 0 views
  • 25 Jan, 2021
  • 1 location
Genetic Analysis of Blood and Tissue Samples From Patients With Advanced Cancer Moonshot Study

This trial studies the genetic analysis of blood and tissue samples from patients with cancer that has spread to other anatomic sites (advanced) or is no longer responding to treatment. Studying these samples in the laboratory may help doctors to learn how genes affect cancer and how they affect a …

investigational drug
biospecimen collection
targeted therapy
recurrent disease
cancer
  • 38 views
  • 16 Feb, 2021
  • 111 locations
Concordance Between Liquid and Tissue Biopsy

Tissue biopsy is a procedure to remove a piece of tissue (sample of cells) from the body to be analyzed in a laboratory, and it is commonly performed to confirm diagnosis of a patient with symptoms of breast cancer recurrence. It may also provide information on tumor markers (hormone receptors, …

  • 0 views
  • 27 Jan, 2021
  • 1 location
Pharmacokinetics and Pharmacogenomics of Ribociclib in Race-based Cohorts

The aim is to determine the pharmacological and biochemical association between ribociclib exposure and CYP3A variants in African American/Blacks and Non-Hispanic White patients. The investigators hypothesize that patients treated with ribociclib who are CYP3A5 poor metabolizers may be exposed to higher levels of ribociclib than CYP3A5 intermediate or normal metabolizers. …

  • 0 views
  • 06 Mar, 2021
  • 2 locations
A Study to Measure the Expression of the HER2-HER3 Dimer in Tumour and Blood (Exosomes) Samples From Patients With HER2 Positive Breast Cancer Receiving HER2 Targeted Therapies

The treatment of breast cancer is determined by its 'receptor (or signal) status'. Receptors are signals present on all cells and if abnormal can drive cancer growth. One of the signals that can drive breast cancer growth is the HER2 receptor/signal. One quarter of all breast cancers are found to …

biomarker analysis
locally advanced breast cancer
taxane
stage iv breast cancer
her1
  • 0 views
  • 23 Jan, 2021
  • 2 locations
Circulating Osteocalcin-positive Cells in Breast Cancer Bone Metastasis

Bone metastasis (i.e. cancer cell spreading to bone) is the major clinical problem of advanced breast cancer patients. Bone metastasis is not curable nor preventable. Currently available therapeutic approaches are only palliative. The major hurdle for improving bone metastasis treatment is lack of sensitive diagnostic tools. Diagnosis of bone metastasis …

  • 0 views
  • 22 Jan, 2021
  • 2 locations
Predictors of Response to Neoadjuvant Docetaxel-Carboplatin Chemotherapy for Patients With Stage II and III Triple Negative Breast Cancer

Neoadjuvant (preoperative) chemotherapy is an interesting research tool which allows investigators to test new drugs and/or new schedules with a validated surrogate endpoint, pCR. It also represents an ideal model to evaluate the relationships between treatments and tumor biomarkers. Recent publications have shown that new molecular classifications of breast cancer …

taxane
carboplatin
docetaxel
invasive breast cancer
advanced breast cancer
  • 0 views
  • 25 Jan, 2021
  • 1 location
Modified Folinic Acid-Fluorouracil-Oxaliplatin Regimen + Capecitabine for Elderly With Metastatic Gastric Cancer

Elderly patients are generally underrepresented in the study populations of combination chemotherapy trials. In gastric cancer patients, oxaliplatin has shown a more favorable toxicity profile than cisplatin. A combination chemotherapy of 5-fluorouracil (5-FU) with oxaliplatin, mainly FOLFOX regimens, has been investigated in numerous phase II studies, using different doses and …

  • 0 views
  • 22 Jan, 2021
  • 1 location