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Found 363 clinical trials
Chemotherapy on Methylation Patterns in Breast Tumor Tissue Correlating With Clinical Response and Outcomes

Primary Objectives 1. To identify hypermethylated genes in paired pretreatment breast tumor tissue and plasma samples from locally advanced and metastatic breast cancer patients

  • 40 views
  • 07 Nov, 2020
  • 1 location
Tumoral Bone Strength Assessment by Numerical Simulation Using Quantitative CT : the MEKANOS Study

Osteolytic bone metastases and myeloma bone lesions are responsible of long bone and vertebral fractures leading to restricted mobility, surgery and medullar compression that severely alter quality of life and that have a huge medico-economic impact. It has been estimated that 50% of the patients with bone metastasis will encounter …

metastasis
ct scan
denosumab
cancer
bone metastases
  • 1 views
  • 23 Jan, 2021
  • 11 locations
[18F] F-GLN by PET/CT in Breast Cancer

Patients with known or suspected primary or metastatic breast cancer with one lesion that is 1.5 cm in diameter or greater may be eligible for this study. Patients may participate in this study

mammogram
estrogen
stage iv breast cancer
triple negative breast cancer
  • 0 views
  • 26 Jan, 2021
  • 1 location
Imaging of Primary or Recurrent Breast Cancer With 18F-FluorThanatrace PET/CT

Patients with known or suspected, in the opinion of an investigator, primary or metastatic breast cancer may be eligible for this study. Up to 30 evaluable patients will undergo study imaging in

stage iv breast cancer
  • 0 views
  • 25 Jan, 2021
Paclitaxel Therapeutic Drug Monitoring in Cancer Patients

The goals of this prospective, observational cohort study are to determine the feasibility of implementing paclitaxel therapeutic drug monitoring for cancer patients and explore the relationship between paclitaxel drug exposure and the development of neuropathic symptoms. This trial studies if paclitaxel can be consistently measured in the blood of patients …

carboplatin
invasive breast cancer
tumor cells
pembrolizumab
pertuzumab
  • 0 views
  • 28 Jan, 2021
  • 1 location
Immune Response to Anti-HER2 Therapies in Patients With HER2-Positive Stage I-IV Breast Cancer

This study gathers information from the blood cells and tumor tissue during treatment with anti-HER2 therapies, such as trastuzumab, pertuzumab, lapatinib, or neratinib, in patients with HER2 positive stage I-IV breast cancer who are scheduled to start anti-HER2 therapy. The information gained from this study may help researchers better understand …

progesterone
cancer
estrogen receptor
trastuzumab
gene amplification
  • 0 views
  • 25 Jan, 2021
  • 1 location
Genetic Analysis of Blood and Tissue Samples From Patients With Advanced Cancer Moonshot Study

This trial studies the genetic analysis of blood and tissue samples from patients with cancer that has spread to other anatomic sites (advanced) or is no longer responding to treatment. Studying these samples in the laboratory may help doctors to learn how genes affect cancer and how they affect a …

targeted therapy
investigational drug
biospecimen collection
cancer
recurrent disease
  • 38 views
  • 16 Feb, 2021
  • 111 locations
Concordance Between Liquid and Tissue Biopsy

Tissue biopsy is a procedure to remove a piece of tissue (sample of cells) from the body to be analyzed in a laboratory, and it is commonly performed to confirm diagnosis of a patient with symptoms of breast cancer recurrence. It may also provide information on tumor markers (hormone receptors, …

  • 0 views
  • 27 Jan, 2021
  • 1 location
Pharmacokinetics and Pharmacogenomics of Ribociclib in Race-based Cohorts

The aim is to determine the pharmacological and biochemical association between ribociclib exposure and CYP3A variants in African American/Blacks and Non-Hispanic White patients. The investigators hypothesize that patients treated with ribociclib who are CYP3A5 poor metabolizers may be exposed to higher levels of ribociclib than CYP3A5 intermediate or normal metabolizers. …

  • 0 views
  • 03 Mar, 2021
  • 2 locations
A Study to Measure the Expression of the HER2-HER3 Dimer in Tumour and Blood (Exosomes) Samples From Patients With HER2 Positive Breast Cancer Receiving HER2 Targeted Therapies

The treatment of breast cancer is determined by its 'receptor (or signal) status'. Receptors are signals present on all cells and if abnormal can drive cancer growth. One of the signals that can drive breast cancer growth is the HER2 receptor/signal. One quarter of all breast cancers are found to …

stage iv breast cancer
locally advanced breast cancer
cancer
advanced breast cancer
trastuzumab
  • 0 views
  • 23 Jan, 2021
  • 2 locations