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Found 55 clinical trials
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A Randomized, Double-Blind, Placebo-Controlled Trial of Adjunctive Troriluzole in Obsessive Compulsive Disorder

This research study is investigating troriluzole (BHV-4157) as a possible treatment for obsessive compulsive disorder (OCD) compared to placebo. Up to 60% of patients with OCD do not have adequate response to approved oral treatments. Troriluzole is an "investigational" or experimental drug, which means that the drug has not been …

  • 0 views
  • 05 Apr, 2021
  • 1 location
featured
A Phase 2a Randomized, Double-blind, Placebo-Controlled, Parallel-Group, Multi-center Study Investigating the Efficacy, Safety, Tolerability and Pharmacokinetics of JNJ-XXX in Subjects with Major Depressive Disorder

A study to evaluate the efficacy of JNJ-XXX compared to placebo when administered as adjunctive treatment in subjects with MDD partially responsive to SSRI/SNRI treatment in terms of reduction of

depressed mood
depressive symptoms
selective serotonin reuptake inhibitors
  • 49 views
  • 23 Nov, 2020
  • 1 location
Sertraline vs. Placebo for Symptoms Following Traumatic Brain Injury

The purpose of this study is to investigate the efficacy of an SSRI, sertraline for the use of post-concussive symptoms following a traumatic brain injury. the study also seeks to

amnesia
post-concussion syndrome
  • 46 views
  • 07 Nov, 2020
  • 1 location
Serotonergic Modulation of Cognition Emotion and Brain Activation in Healthy Volunteers

The aim of this project is: To apply a pharmacological tool of selective serotonin (5-hydroxytryptamine, 5-HT system) reuptake inhibition in healthy humans. Specifically: To investigate how sub-chronic administration of 20 mg of escitalopram affects cognitive performance ('cold' cognition) and social-emotional functioning ('hot' cognition) compared with placebo; and To investigate how …

  • 52 views
  • 25 Jan, 2021
  • 1 location
Treatment Youth With Obsessive-Compulsive Disorder

Although research suggests that patients with obsessive-compulsive disorder (OCD) exhibit specific deficits in their high cognitive processes, it is still unknown how these deficits relate to the clinical symptoms of the disorder, and to the response to treatment. There are two aims for the proposed research. The first is to …

psychotropic drugs
anxiety
citalopram
  • 134 views
  • 07 Nov, 2020
  • 1 location
Effect of Acupressure in Migraine: Single-blinded Randomized Controlled Clinical Trial

Background : Migraine is one of the most complex, prevalent, debilitating neurologic disorder in the world. In clinical experience, there are limitation over western medicine for migraine, especially some extra adverse effects. In traditional Chinese medicine(TCM), there are some reviews and clinical practice point out acupressure at PC6 could relieve …

calcitonin
nausea
calcitonin gene-related peptide
  • 0 views
  • 14 Jul, 2021
  • 1 location
A Long-term Comparison of Esketamine Nasal Spray Versus Quetiapine Extended Release Both in Combination With a Selective Serotonin Reuptake Inhibitor/Serotonin-Norepinephrine Reuptake Inhibitor in Participants With Treatment Resistant Major Depressive Disorder

selective serotonin reuptake inhibitor/serotonin-norepinephrine reuptake inhibitor (SSRI/SNRI), in achieving remission in participants who have treatment-resistant major depressive disorder (MDD) with a

  • 0 views
  • 25 Jul, 2021
  • 215 locations
A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy

participants with major depressive disorder with insomnia symptoms (MDDIS) who have had an inadequate response to current antidepressant therapy with a selective serotonin reuptake inhibitor (SSRI) or

  • 0 views
  • 25 Jul, 2021
  • 88 locations
A Study of Seltorexant Compared to Quetiapine XR as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy

participants with major depressive disorder with insomnia symptoms (MDDIS) who have had an inadequate response to current antidepressant therapy with a selective serotonin reuptake inhibitor (SSRI) or

structured clinical interview
paroxetine
depressive symptoms
quetiapine
venlafaxine
  • 124 views
  • 04 Jul, 2021
  • 179 locations
A Long-Term Extension Study for Participants With Treatment-resistant Major Depressive Disorder Who Are Continuing Esketamine Nasal Spray Treatment

-norepinephrine reuptake inhibitor (SSRI/SNRI) in participants who have completed 32 weeks of esketamine nasal spray treatment in Study 54135419TRD3013 (NCT04338321).

  • 0 views
  • 25 Jul, 2021
  • 55 locations