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Found 753 clinical trials
Cisplatin + Radiotherapy vs Durvalumab + Radiotherapy Followed by Durvalumab vs Durvalumab + Radiotherapy Followed by Tremelimumab + Durvalumab in Intermediate-Risk HPV-Positive Oropharyngeal SCC

Sometimes, cancer patients receive an initial treatment, followed by additional treatment to lower the chance of cancer coming back. The standard or usual treatment for this type of disease is initially having radiation therapy at the same time as chemotherapy (with a drug called cisplatin), with no additional therapy afterwards

x-rays
neutrophil count
durvalumab
human papillomavirus
oropharyngeal carcinoma
  • 56 views
  • 31 Jan, 2021
  • 30 locations
Study of GSK3359609 and Pembrolizumab in Programmed Death Receptor 1-ligand 1 Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

/M) head and neck squamous cell carcinoma/cancer (HNSCC). This is a randomized, double-blind, adaptive Phase II/III study comparing a combination of GSK3359609 inducible T cell co-stimulatory

carcinoma of oropharynx
gsk3359609
pembrolizumab
squamous cell carcinoma
measurable disease
  • 6 views
  • 25 Feb, 2021
  • 184 locations
Study of GSK3359609 With Pembrolizumab and 5-fluorouracil (5-FU)-Platinum Chemotherapy in Participants With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

with 5FU-platinum based chemotherapy in participants with recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). This randomized, double-blinded, Phase II/III study will compare

carcinoma of oropharynx
gsk3359609
pembrolizumab
squamous cell carcinoma
carboplatin
  • 0 views
  • 25 Feb, 2021
  • 74 locations
Oral Cancer Adjuvant Therapy (OCAT) Trial

/ week instead of 5 fractions / week improves local-regional control and / or overall survival in high risk, locally advanced, resectable, squamous cell carcinoma of oral cavity.

caries
squamous cell carcinoma of the oral cavity
chemoradiotherapy
carcinoma
squamous cell carcinoma
  • 60 views
  • 07 Nov, 2020
  • 1 location
  • 22 views
  • 27 Jan, 2021
  • 42 locations
A Study of ASP1948 Targeting an Immune Modulatory Receptor as a Single Agent and in Combination With a PD-l Inhibitor (Nivolumab or Pembrolizumab) in Subjects With Advanced Solid Tumors

The purpose of this study is to evaluate the tolerability and safety profile of ASP1948 when administered as a single agent and in combination with nivolumab or pembrolizumab in participants with locally advanced (unresectable) or metastatic solid tumors; characterize the pharmacokinetic profile of ASP1948 when administered as a single agent …

  • 75 views
  • 03 Mar, 2021
  • 37 locations
The Method ISET (Insulation by Size of Epithelial Tumor Cells)

The aim of this study is, i) to assess the presence and the frequency of CTC in NSCLC patients undergoing surgery by using cytopathological analysis after their isolation by size (ISET method), and, ii) to correlate the presence of CNHC with pTNM stage, histological subtype, and percentage of tumor cells …

carcinoma
  • 1 views
  • 07 Nov, 2020
  • 1 location
Efficacy of INCMGA00012 in Penile Squamous Cell Carcinoma (ORPHEUS)

This is a multicenter, open-label, single-arm, phase II clinical trial to evaluate the efficacy and safety of INCMGA00012 in Advanced Penile Squamous Cell Carcinoma

  • 0 views
  • 27 Jan, 2021
  • 14 locations
Local Therapy for Oligorecurrent and Oligometastatic Esophageal Squamous Cell Carcinoma

squamous cell carcinoma led to significant improvements in progression-free survival (PFS).

  • 0 views
  • 28 Jan, 2021
  • 1 location
Neoadjuvant Sintilimab in Combination With Carboplatin and Nab-paclitaxel in Untreated Oral Cavity Squamous Cell Carcinoma

The purpose of this study is to look at the efficacy and safety of sintilimab in combination with carboplatin and nab-paclitaxel in patients with oral squamous cell carcinoma(OSCC) who are about

  • 0 views
  • 10 Feb, 2021
  • 2 locations