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Found 33 clinical trials
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Oral Cancer Adjuvant Therapy (OCAT) Trial

/ week instead of 5 fractions / week improves local-regional control and / or overall survival in high risk, locally advanced, resectable, squamous cell carcinoma of oral cavity.

chemoradiotherapy
carcinoma
squamous cell carcinoma of the oral cavity
adjuvant therapy
carcinoma of oral cavity
  • 60 views
  • 07 Nov, 2020
  • 1 location
None
Pharmacokinetic (PK) Analysis of Antitumor B in Patients With Oral Cancer

A Window of Opportunity Clinical Trial. This study design permits examination of effects of an oral agent on cancer patients during the "window" between diagnosis of their cancer and their definitive cancer surgery. Similar to a phase 0 study, the trial design permits examination of the biologic effects of an …

  • 6 views
  • 26 Sep, 2021
  • 1 location
None
Low Level Laser Therapy for Radiation Induced Dermatitis in H & N Squamous Cell Carcinoma

target population is patients with histologically proven squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx or larynx who are candidates for either definitive or adjuvant therapy

  • 2 views
  • 24 Jan, 2021
  • 1 location
None
Surgery and Radiation Therapy With or Without Interleukin-2 in Treating Patients With Cancer of the Mouth or Oropharynx

RATIONALE: Interleukin-2 may stimulate a person's white blood cells to kill cancer cells of the mouth or oropharynx. Radiation therapy uses high-energy x-rays to damage tumor cells. It is not known whether giving interleukin-2 with surgery and radiation therapy is more effective than surgery and radiation therapy alone. PURPOSE: This …

immunomodulator
tumor cells
interleukin-2
x-rays
oral cancer
  • 18 views
  • 07 Nov, 2020
  • 1 location
None
NBTXR3 and Radiation Therapy in Treating Patients With Locally Advanced SCC of the Oral Cavity or Oropharynx

RATIONALE: Cancers of the oral cavity represent 30% of head and neck carcinomas in the western world. The oropharynx is the posterior continuation of the oral cavity and connects with the nasopharynx (above) and laryngopharynx (below). It is also a frequent site of primary head and neck cancers. These structures …

primary tumor
definitive treatment
positron emission tomography
chemoradiotherapy
carcinoma
  • 47 views
  • 16 May, 2021
  • 20 locations
None
Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

This phase II/III trial studies how well sentinel lymph node biopsy works and compares sentinel lymph node biopsy surgery to standard neck dissection as part of the treatment for early-stage oral cavity cancer. Sentinel lymph node biopsy surgery is a procedure that removes a smaller number of lymph nodes from …

mouth cancer
cavity
step 2
ct scan
chest x-ray
  • 0 views
  • 15 Nov, 2021
  • 26 locations
None
Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug Atezolizumab to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

This phase II/III trial studies how well radiation therapy works when given together with cisplatin, docetaxel, cetuximab, and/or atezolizumab after surgery in treating patients with high-risk stage III-IV head and neck cancer the begins in the thin, flat cells (squamous cell). Specialized radiation therapy that delivers a high dose of …

antibiotics
epidermal growth factor
neck cancer
atezolizumab
primary tumor
  • 17 views
  • 05 Dec, 2021
  • 142 locations
None
Effectiveness of Adjuvant Radiotherapy in Small Oropharyngeal Squamous Cell Cancer and Single Lymph Node Metastasis.

Radiotherapy with or without adjuvant chemotherapy represents an important column of modern therapy in advanced squamous cell originated tumours of the head and neck. However to date no studies are available which study the effectiveness of radiotherapy in patients with resected small tumours (T1, T2) and concomitant ipsilateral metastasis of …

cavity
caries
carcinoma
squamous cell carcinoma of the oral cavity
squamous cell carcinoma
  • 36 views
  • 08 Nov, 2020
None
Durvalumab With or Without Tremelimumab in Resectable Locally Advanced Squamous Cell Carcinoma of the Oral Cavity

tissue acquisition in patients with newly diagnosed advanced (stage IV) oral cavity SCC. Patients are treated with Durvalumab (arm A) or Durvalumab + Tremelimumab (arm B) after biopsy-confirmed diagnosis

  • 0 views
  • 22 Jan, 2021
  • 1 location
None
Preservation of Swallowing in Respected Oral Cavity Squamous Cell Carcinoma: Examining Radiation Volume Effects (PRESERVE): A Randomized Trial

The goal of this randomized treatment study is to formally compare quality of life in patients with at least one pN0 hemi-neck after resection of a squamous cell carcinoma of the oral cavity

carcinoma
mouth cancer
dental caries
squamous cell carcinoma of the oral cavity
squamous cell carcinoma
  • 2 views
  • 18 Aug, 2021
  • 4 locations