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Found 28 clinical trials
Pharmacokinetic (PK) Analysis of Antitumor B in Patients With Oral Cancer

A Window of Opportunity Clinical Trial. This study design permits examination of effects of an oral agent on cancer patients during the "window" between diagnosis of their cancer and their definitive cancer surgery. Similar to a phase 0 study, the trial design permits examination of the biologic effects of an …

  • 6 views
  • 06 Jun, 2022
  • 1 location
NBTXR3 and Radiation Therapy in Treating Patients With Locally Advanced SCC of the Oral Cavity or Oropharynx

RATIONALE: Cancers of the oral cavity represent 30% of head and neck carcinomas in the western world. The oropharynx is the posterior continuation of the oral cavity and connects with the nasopharynx (above) and laryngopharynx (below). It is also a frequent site of primary head and neck cancers. These structures …

squamous cell carcinoma of the oral cavity
primary tumor
neutrophil count
carcinoma
mouth cancer
  • 47 views
  • 24 Jan, 2022
  • 20 locations
Preservation of Swallowing in Respected Oral Cavity Squamous Cell Carcinoma: Examining Radiation Volume Effects (PRESERVE): A Randomized Trial

The goal of this randomized treatment study is to formally compare quality of life in patients with at least one pN0 hemi-neck after resection of a squamous cell carcinoma of the oral cavity

squamous cell carcinoma of the oral cavity
squamous cell carcinoma
dental caries
mouth cancer
carcinoma
  • 2 views
  • 08 Aug, 2022
  • 6 locations
Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

This phase II/III trial studies how well sentinel lymph node biopsy works and compares sentinel lymph node biopsy surgery to standard neck dissection as part of the treatment for early-stage oral cavity cancer. Sentinel lymph node biopsy surgery is a procedure that removes a smaller number of lymph nodes from …

cavity
cancer
step 2
mouth cancer
chest x-ray
  • 12 views
  • 24 May, 2022
  • 25 locations
Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

This phase II/III trial studies how well radiation therapy works when given together with cisplatin, docetaxel, cetuximab, and/or atezolizumab after surgery in treating patients with high-risk stage III-IV head and neck cancer the begins in the thin, flat cells (squamous cell). Specialized radiation therapy that delivers a high dose of …

neutrophil count
absolute neutrophil count
antibiotics
serum pregnancy test
head and neck cancer
  • 109 views
  • 11 Aug, 2022
  • 130 locations
Gross Examinations Versus Frozen Section for Assessment of Surgical Margins in Oral Cancers

Surgical margin is a significant prognostic factor in oral cavity squamous cell carcinoma (OCSCC)[1,2,3]. Intra-operative frozen section (FS) has been routinely used by the surgeons to achieve

  • 0 views
  • 12 May, 2022
  • 1 location
Biofeedback Rehabilitation to Improve Speaking and Eating in Public (Biofeedback)

Tongue cancer requires resection and reconstruction that can leave patients disabled with respect to speaking and eating. Impairment of tongue function can have significant impact on social interaction and employment. To try and improve speaking and eating in public, the team at the University Health Network is going to use …

cavity
cancer
mouth cancer
adjuvant radiation therapy
upper dentures
  • 1 views
  • 15 Jun, 2022
  • 1 location
Study Comparing Fibula Free-flap MR With or Without PVP in Patients With OOPC (CURVE)

This is a national multicenter, randomized, stratified, open label study, aiming to compare mandibular reconstruction (MR) with or without preoperative virtual planning (PVP), in patients with oral/oropharyngeal cancer (OOPC).

  • 0 views
  • 30 May, 2022
  • 1 location
Neoadjuvant Sintilimab Combined With Reduction of Cycles of Chemotherapy in Resectable Oral Cavity or Oropharyngeal Squamous Cell Carcinoma (OOC-002)

The study is being conducted to evaluate the efficacy and safety of sintilimab in combination with reduction of cycles of chemotherapy (carboplatin and nab-paclitaxel) in patients with oral cavity or oropharyngeal squamous cell carcinoma who are about to undergo surgery. Data obtained in this trial will provide valuable information for …

  • 1 views
  • 04 Nov, 2021
  • 1 location
Activity and Safety of Peptide-based Immunotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck. (HN1901)

The purpose of this project is to realize a randomized open-label study (EudraCT number: 2020-000120-19) to evaluate the safety and the anti-tumor activity of peptide(s)-based immunotherapy in an umbrella window pre-operative opportunity phase II study in patients with squamous cell carcinoma of the head and neck.

cavity
carcinoma in situ of cervix
neutrophil count
carcinoma
cancer
  • 0 views
  • 25 May, 2022
  • 1 location