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Found 18 clinical trials
Eltrombopag Combining Rituximab Versus Eltrombopag in the Management of Primary Immune Thrombocytopenia (ITP) in Adults

conducted in adult ITP patients who had not responded to or had relapsed after previous treatment of ITP, including first line therapy and /or splenectomy.

  • 0 views
  • 25 Jan, 2021
  • 1 location
Distal Pancreatectomy Minimally Invasive or Open for Malignancy (DIPLOMA)

with splenectomy because of proven or highly suspected PDAC. Intervention: Minimally invasive distal pancreatectomy (either laparoscopic or robot-assisted) Control: Open distal

pdac
cancer
  • 0 views
  • 25 Jan, 2021
  • 4 locations
Immunologic Response to Pneumococcal Polysaccharide Vaccine in Splenic Injury Patients

Persons without a spleen are susceptible to potentially lethal infections from certain bacteria, with pneumococcus being the most prevalent. Vaccines are provided to help protect against these infections, though they do not so with certainty. Trauma patients who sustain an injury to their spleen currently have three treatment options available …

  • 1 views
  • 26 Jan, 2021
  • 1 location
A Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis Post Polycythemia Vera Myelofibrosis or Post-Essential Thrombocythemia Myelofibrosis

This study (study ID PAC203 North America; PAC303 ex-North America) is evaluating 200 mg BID of pacritinib compared to physician's choice (P/C) therapy in patients with MF and severe thrombocytopenia (platelet count <50,000/L). Approximately 348 patients in total will be enrolled, randomized 2:1 to either pacritinib (approximately 232 patients) or …

myelofibrosis
thrombocythemia
ruxolitinib
renal function
international normalized ratio
  • 506 views
  • 05 May, 2021
  • 176 locations
Transfusion Trigger After Operations in High Cardiac Risk Patients

The goal of the proposed study is to determine whether a liberal transfusion strategy (transfusion trigger at Hb < 10 gm/dl) in Veterans at high cardiac risk who undergo major open vascular and general surgery operations is associated with decreased risk of adverse postoperative outcomes compared to a restrictive transfusion …

vascular surgical procedures
angina pectoris
coronary artery bypass graft
ischemia
percutaneous coronary intervention
  • 12 views
  • 26 Jan, 2021
  • 14 locations
Laparoscopic Splenectomy and Azygoportal Disconnection With Intraoperative Endoscopic Variceal Ligation

This study aimed to evaluate whether synchronous vagus nerve-preserving laparoscopic splenectomy and azygoportal disconnection with intraoperative endoscopic variceal ligation (SVEL) is

splenectomy
thrombosis
esophageal varices
cirrhosis
  • 0 views
  • 01 May, 2021
  • 1 location
  • 0 views
  • 28 Jan, 2021
  • 1 location
Laparoscopic Versus Open Devascularization for Portal Hypertension a Randomized Controlled Trial

Many patients with portal hypertension require surgical treatment each year,and Hassab's operation, or esophagogastric devascularization and splenectomy, is an elective procedure. In recent

hypertension
esophageal varices
gastric varices
splenectomy
varicose veins
  • 6 views
  • 08 Nov, 2020
  • 1 location
Early Drain Removal Versus Standard Drain Management After Distal Pancreatectomy (Early-Dist)

without splenectomy will be enrolled.The primary outcome is the POPF at 90 days after surgery, defined as grade B or C POPF according to ISGPS definition. Participants will be asked to complete

  • 0 views
  • 03 Feb, 2021
  • 1 location
Romiplostim Rituximab and Dexamethasone as Frontline Treatment for Immune Thrombocytopenia

The purpose of this study is to determine the response rate and response duration with the combination of low-dose rituximab, romiplostim and high-dose dexamethasone.

thrombocytopenia
platelet count
romiplostim
dexamethasone
rituximab
  • 0 views
  • 25 Jan, 2021
  • 1 location