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Found 45 clinical trials
Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction

an Aldosterone Antagonist) suggest spironolactone may be effective in HFPEF, but it is generic and will not be studied by industry. SPIRRIT is a unique Registry-Randomized Clinical Trial

aldosterone
natriuretic peptide
spironolactone
aldosterone antagonists
n-terminal pro-bnp
  • 46 views
  • 06 Jan, 2020
  • 119 locations
Aldosterone bloCkade for Health Improvement EValuation in End-stage Renal Disease

dialysis. Spironolactone is a pill used to prevent heart failure and related deaths in patients that do not require dialysis. It works by blocking a hormone (aldosterone) in your body that causes

  • 41 views
  • 05 Nov, 2020
  • 98 locations
ACEI/CCB Versus ACEI/DIU Combination Antihypertensive Therapy in Chinese Hypertensive Patients (ACvAD)

Study name: ACEI/CCB versus ACEI/DIU combination antihypertensive therapy in Chinese hypertensive patients (ACvAD) Medicine: Benazepril 10 mg / amlodipine besylate 5 mg fixed-dose combination, benazepril 10 mg / hydrochlorothiazide 12.5 mg fixed-dose combination. Rationale:Most hypertension guidelines, including the Chinese guidelines for hypertension, recommend the combination of angiotensin-converting enzyme inhibitors (ACEI) …

thiazide
angiotensin ii receptor antagonist
blood pressure diastolic
amlodipine
angiotensin
  • 8 views
  • 08 Nov, 2020
  • 1 location
Spironolactone After Liver Transplant

To study spironolactone to prevent CNI kidney injury.

  • 16 views
  • 08 Nov, 2020
  • 1 location
Spironolactone for Paroxysmal Atrial Fibrillation

To determine whether or not spironolactone can prevent or delay the occurrence of atrial fibrillation.

paroxysmal atrial fibrillation
  • 4 views
  • 07 Nov, 2020
  • 1 location
Spironolactone Versus Prednisolone in DMD

This is a randomized, open-label, pilot clinical trial of spironolactone suspension versus oral prednisolone for use in Duchenne muscular dystrophy. The goals are to determine the safety of 6

ejection fraction
corticosteroids
muscle biopsy
muscular dystrophy
dmd gene
  • 36 views
  • 24 Feb, 2020
  • 1 location
Cardiovascular Protective Effect of Spironolactone in Hemodialysis

The purpose of the present study is to determine if spironolactone is safe and effective in the treatment of cardiovascular complications in hemodialysis patients.

spironolactone
  • 57 views
  • 07 Nov, 2020
  • 1 location
Aldosterone in Diabetic Nephropathy

The purpose of this study is to determine whether spironolactone are effective in the reduction of albuminuria and diastolic disfunction of subjects with diabetic nephropathy.

spironolactone
aldosterone
nephropathy
diabetic nephropathy
kidney function tests
  • 29 views
  • 07 Nov, 2020
  • 1 location
Mineralocorticoid Receptor Antagonism Clinical Evaluation in Atherosclerosis Trial

, slowly progressive and cumulative, resulting in heart attack, stroke and/or death and blockage of arteries. This study is being done to assess the effectiveness of Spironolactone therapy to slow

type 2 diabetes mellitus
atherosclerosis
hypercholesterolemia
glycosylated hemoglobin
insulin
  • 49 views
  • 08 Nov, 2020
  • 1 location
Adrenal Artery Ablation for Uncontrolled Hypertension

have to take spironolactone or other antihypertensive drugs for long time. On the other side, long-term inhibition of aldosterone receptor may cause hyperkalemia, male breast hyperplasia and other

  • 0 views
  • 08 Nov, 2020
  • 1 location