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Found 30 clinical trials
Aldosterone bloCkade for Health Improvement EValuation in End-stage Renal Disease

dialysis. Spironolactone is a pill used to prevent heart failure and related deaths in patients that do not require dialysis. It works by blocking a hormone (aldosterone) in your body that causes

  • 193 views
  • 26 Jan, 2021
  • 98 locations
Fibrosis and the Fontan

antifibrotic agent, spironolactone, to prevent these consequences and to determine if MRI can discern these differences. The combination of serum biomarkers and MRI form a powerful non-invasive tool in putting

  • 0 views
  • 04 Jun, 2021
  • 1 location
Transgender Estradiol Affirming Therapy

The purpose of this open label, pilot, randomized clinical trial is to evaluate the effectiveness, safety and tolerability of estrogen use in transgender female and the degree of testosterone suppression achieved in this population when placed on gender affirming pharmacological therapy.

  • 0 views
  • 27 Aug, 2021
  • 1 location
Spironolactone In The Treatment of Heart Failure

) spironolactone reduces a composite of recurrent heart failure hospitalizations and cardiovascular mortality.

  • 0 views
  • 03 Feb, 2021
  • 64 locations
Colchicine and Spironolactone in Patients With MI / SYNERGY Stent Registry (CLEAR SYNERGY)

well as the non-culprit arteries (randomization to routine colchicine and spironolactone).

troponin
colchicine
stemi
diabetes
  • 23 views
  • 01 Mar, 2022
  • 1 location
Study to Assess Efficacy and Safety of SZC for the Management of High Potassium in Patients With Symptomatic HFrEF Receiving Spironolactone (REALIZE-K)

The main objective of this study is to evaluate the efficacy of SZC as compared with placebo in keeping potassium levels within the normal range (3.5-5.0 mEq/L) while on spironolactone ≥25 mg

  • 10 views
  • 19 Jun, 2022
  • 37 locations
Spironolactone for Pulmonary Arterial Hypertension

death rate remains unacceptably high. Lung blood vessel function can be harmed by progressive injuries, such as inflammation, leading to worsening of the disease. A drug called spironolactone has been

walk tests
hypertension
pulmonary function test
spironolactone
medical therapy
  • 11 views
  • 20 Jun, 2022
  • 1 location
Spironolactone Therapy In Young Women With NASH

contribute to NASH, the investigators are conducting a pilot clinical trial to primarily assess the feasibility of using an androgen blocking medication, spironolactone, in women with NASH. Spironolactone

fatty liver
testosterone
cirrhosis
  • 37 views
  • 05 Mar, 2022
  • 1 location
Spironolactone in CKD Enabled by Chlorthalidone: PILOT (SPICE PILOT)

cardiovascular (CV) disease. Spironolactone (SPL), a mineralocorticoid receptor antagonist, is widely used to treat resistant hypertension, however one of the most common side effects is an increase of serum

antihypertensive drugs
ace inhibitor
hypertension
  • 0 views
  • 23 Mar, 2022
  • 1 location
Spironolactone Therapy in Chronic Stable Right HF Trial (STAR-HF)

The purpose of this study is to evaluate the safety, tolerability and mechanistic effects of spironolactone, an aldosterone receptor antagonist, on sympathetic nervous system activity and right

hypertension
tapse
right ventricular failure
spironolactone
diuretics
  • 66 views
  • 03 Mar, 2022
  • 1 location