Found 590 clinical trials
A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma
: How much tumor is left after surgery If the cancer has spread to other sites outside the brain [i.e., to the spinal cord or within the fluid surrounding the spinal cord, called
- 144 views
- 25 May, 2022
- 1 location
Phase 3, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Apitegromab (SRK-015) in Patients With Later-Onset Spinal Muscular Atrophy Receiving Background Nusinersen or Risdiplam Therapy (SAPPHIRE)
This Phase 3 trial (Study SRK-015-003) is being conducted in patients ≥2 years old at Screening, who were previously diagnosed with later-onset spinal muscular atrophy (SMA) (i.e., Type 2 and Type 3 SMA) and are receiving an approved survival motor neuron (SMN) upregulator therapy (i.e., either nusinersen or risdiplam), to …
- 0 views
- 23 Oct, 2022
- 24 locations
Outcomes Mandate National Integration With Cannabis as Medicine (OMNI-Can)
This will be a multistate, multicenter clinical study to determine the efficacy and safety of medical cannabis for a wide variety of chronic medical conditions.
- 15233 views
- 13 Jun, 2022
- 16 locations
SAkuraBonsai: Clinical, Imaging And Biomarker Open-Label Study In Neuromyelitis Optica Spectrum Disorder (NMOSD) With Satralizumab As An Intervention (SAkuraBonsai)
Objective of the trial is to describe the efficacy and safety of satralizumab in patients with aquaporin-4 (AQP4) antibody seropositive NMOSD, either treatment naive or inadequate responders to previous treatment with rituximab (RTX) (or its biosimilar)
- 0 views
- 10 Oct, 2022
- 5 locations
Dexmedetomidine Supplemented Analgesia and Delirium After Hip Fracture Surgery
Delirium is common in the elderly after hip fracture surgery, and is associated with worse outcomes. The investigators hypothesize that, for elderly patients after hip fracture surgery, dexmedetomidine supplemented analgesia can reduce the incidence of delirium and improve the long-term outcomes.
- 0 views
- 08 Dec, 2021
- 1 location
Stereotactic Ablative Radiotherapy for Comprehensive Treatment of Oligometastatic (1-3 Metastases) Cancer (SABR-COMET-3)
Stereotactic Ablative Radiotherapy (SABR) is a modern RT technique that delivers high doses of radiation to small tumor targets using highly conformal techniques. SABR is non-invasive and delivered on an outpatient basis. The purpose of this study is to compare the effect of SABR, relative to standard of care (SOC) …
- 88 views
- 04 Oct, 2022
- 14 locations
PAlliative RAdioTherapy to Lung Cancer A Randomized Multicentre Phase III Study (PARAT)
The aim of this study is to examine if a shorter palliative radiotherapy fractionation scheme of 20 Gy / 4 F can reduce the early oesophageal toxicity compared to 30 Gy / 10 F in patients with lung cancer in performance status (PS) 0-2. Secondary aims are to examine the …
- 2 views
- 05 Jun, 2022
- 1 location
Closed-loop Functional Spinal Cord Stimulation in Patients With Spinal Cord Injury
The purpose of this experiment is to evaluate the efficacy of Closed-loop Functional Spinal Cord Stimulation on Walking Rehabilitation in Patients after Spinal Cord Injury
- 0 views
- 31 Jul, 2021
- 1 location
Spinal Cord Injury - Exercise
Long lasting inflammation in the body is related to cardiovascular and respiratory disease, which are the two most common causes of death in people living with spinal cord injury (SCI
- 0 views
- 12 Jul, 2022
- 1 location
Spinal Cord Stimulation for Spinal Cord Injury Patients - Regain Walk and Alleviate Pain
The study aims to examine the plausible interventional mechanisms underlying the effects of epidural spinal cord stimulation.
- 0 views
- 07 Oct, 2022
- 1 location