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Found 720 clinical trials
rTMS in Treatment of Spasticity

This is an open-label clinical trial to determine the safety and efficacy of rTMS in reducing spasticity and improving quality of life among patients with upper motor neuron predominant motor neuron disease (MND).

primary lateral sclerosis
motor neuron disease
  • 26 Jan, 2021
  • 1 location
Assessment of Poliovirus Type 2 Immunogenicity of One and Two Dose Schedule With IPV and fIPV When Administered at 9-13 Months of Age in Bangladesh

Following a recommendation on October 2017 meeting of the Strategic Advisory Group of Experts (SAGE) on Immunization; low- risk bOPV-using countries may adopt 2 dose fIPV schedule prior to global OPV cessation as it provides better seroconversion than 1 full dose IPV and in the post-cessation era, the 2 fIPV …

routine immunization
severe malnutrition
bleeding disorder
  • 05 May, 2021
  • 2 locations
Respiratory Muscle Training (RMT) in ALS

Twelve adults with ALS will participate in a study involving four 3-week cycles of progressive respiratory muscle training (RMT). The investigators will measure maximum inspiratory pressure (MIP) and maximum expiratory pressure (MEP) weekly. The investigators will obtain the majority of measurements of MIP and MEP during web-based telehealth visits. Participants …

treatment regimen
  • 28 Jul, 2021
  • 1 location
Motor Neurone Disease - Systematic Multi-Arm Adaptive Randomised Trial

MND-SMART is investigating whether selected drugs can slow down the progression of motor neurone disease (MND) and improve survival. The study is 'multi-arm' meaning more than one treatment will be tested at the same time. In the first instance the trial will have 3 arms; drug 1, drug 2 and …

neurodegenerative disorders
primary lateral sclerosis
motor neuron disease
progressive muscular atrophy
  • 03 Jul, 2021
  • 8 locations
Efficacy Of Oral Trehalose In Spinocerebellar Ataxia 3

This study evaluates the effectiveness of oral trehalose in alleviating the neuropathological and motor behaviour deficits among patients with SCA3. A total of 40 participants with SCA3 will be recruited, with 20 participants to be administered with trehalose while another 20 participants to be administered with a maltose placebo.

  • 26 Jan, 2021
  • 1 location
Neuropsychiatry and Cognition in SCA3/MJD

This research investigates how cognitive-affective aspects evolve during the course of SCA3/MJD. Due to COVID-19 pandemics, this study protocol was adapted for online-only consultations. Evaluations happening after March 2020 have been done by videocall with patients, and no neurological evaluation was thus performed on these patients. A scale on Activities …

  • 03 Feb, 2021
  • 1 location
Molecular Imaging Modality by Positron Emission Tomography Using 18F-X : Study of Microglial Activation in Amyotrophic Lateral Sclerosis

PET imaging of activated microglia offers a tool of investigation of a range of brain diseases where neuroinflammation is a component. Amyotrophic lateral sclerosis is the most frequent motoneuronal disease in adult. This study was designed to explore the feasibility of molecular imaging modality by Positron Emission Tomography using 18F-X …

positron emission tomography
primary lateral sclerosis
  • 07 Nov, 2020
Natural History of Spinocerebellar Ataxia Type 7 (SCA7)

Background Spinocerebellar ataxia type 7 (SCA7) is disease in which people have problems with coordination, balance, speech and vision. It is caused by a change in the ATXN7 gene. A mutation in this ATXN7 gene causes changes in eye cells, which can lead to vision loss. There is no cure …

eye drops
spinocerebellar ataxia type 1
skin biopsy
flashing lights
  • 05 Feb, 2021
  • 1 location
National Registry for Egyptian Pediatric Neuromuscular Diseases

Our aim is to establish multi-center national Egyptian database of information for inherited and acquired neuromuscular diseases in infants and children from 0 to 18 years of age.

neuromuscular diseases
nerve conduction study
  • 08 Nov, 2020
  • 1 location
The EUROSCA Natural History Study

The key goals of EUROSCA-NHS is to determine and compare the rate of disease progression in SCA1, SCA2, SCA3 and SCA6 including determination of the order and occurrence of non-ataxia symptoms, assessment of activities of daily living (ADL) and quality of life (QoL), and identification of predictors of disease progression …

spinocerebellar ataxia type 1
genetic testing
  • 21 Jan, 2021
  • 10 locations