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Found 690 clinical trials
Multiple Ascending Dose Study of CTI-1601 Versus Placebo in Subjects With Friedreich's Ataxia

To evaluate the safety and tolerability of multiple ascending doses of CTI-1601 in participants with Friedreich's ataxia

  • 5 views
  • 24 Jan, 2021
  • 1 location
Biomarker for Friedreich's Ataxia (BioFridA)

International, multicenter, observational, longitudinal monitoring study to identify biomarker/s for Friedreich's Ataxia and to explore the clinical robustness, specificity, and long-term variability of these biomarker/s

  • 0 views
  • 11 Apr, 2021
  • 1 location
Safety and Efficacy of Etravirine in Friedreich Ataxia Patients

A drug repositioning effort provided evidence supporting the possible use of Etravirine, a drug approved for the treatment of HIV infections in patients starting from 2 years of age, as a treatment for FA. We found that Etravirine is able to increase Frataxin protein both in vitro - in cells …

  • 0 views
  • 27 Jan, 2021
  • 1 location
Efficacy and Safety Study of Oral Edaravone Administered in Subjects With ALS

To evaluate and compare the efficacy of two dosing regimens of oral edaravone in subjects with amyotrophic lateral sclerosis (ALS) based on the change in ALS Functional Rating ScaleRevised (ALSFRS-R) score from baseline up to Week 48:

  • 0 views
  • 11 Apr, 2021
  • 20 locations
A Study to Assess the Efficacy and Safety of Vatiquinone for the Treatment of Participants With Friedreich Ataxia

The primary objective of the study is to evaluate the efficacy (using the modified Friedreich Ataxia Rating Scale [mFARS]) and safety of vatiquinone in participants with Friedreich ataxia (FA).

  • 0 views
  • 03 Apr, 2021
  • 10 locations
Effect of Lactoferrin on Polio Seroconversion

A massive decline in cases of poliomyelitis was observed worldwide since 1988; however its transmission continues in Pakistan and Afghanistan. In 2017, a total of 17 cases were reported from these countries, which represent approximately half of the cases reported in 2016. This achievement was made possible by large scale …

inactivated poliovirus vaccine
malnutrition
poliomyelitis vaccine
oral poliovirus vaccine
5 minutes
  • 0 views
  • 25 Jan, 2021
  • 1 location
Amyotrophic Lateral Sclerosis (ALS) Families Project

This program provides family members of individuals with familial ALS the opportunity to contribute to research focused on learning more about why motor neuron degeneration begins and how or why it progresses. This study provides genetic counseling and testing to help participants understand and manage their risk and determine if …

dementia
genetic testing
motor neuron degeneration
primary lateral sclerosis
  • 0 views
  • 26 Jan, 2021
Clinical Trial of Novel OPV2 Vaccine

Though OPV is safe and effective, it can mutate and reacquire neurovirulence in rare circumstances. This can result in vaccine-associated paralytic polio and circulating vaccine-derived polioviruses. Use of tOPV had risk of generating VAPP and seeding new type 2 circulating vaccine-derived polioviruses though wild type 2 virus was eradicated in …

  • 0 views
  • 27 Jan, 2021
  • 1 location
nOPV2 and bOPV Trial

This is an open-label randomized clinical trial that will compare immune responses among infants who receive either novel monovalent oral poliovirus vaccine type 2 (nOPV2) alone, bivalent oral poliovirus vaccine (bOPV) alone, or co-administered nOPV2 and bOPV.

  • 0 views
  • 02 Mar, 2021
  • 1 location
Study of Novel Types 1 and 3 Oral Poliomyelitis Vaccines

The purpose of this study is to assess the safety (primary objective) and immunogenicity (secondary objective) and fecal shedding of vaccine viruses (secondary objective) of two novel oral polio vaccines, nOPV1 and nOPV3, as compared to Sabin monovalent vaccine controls, in 230 healthy adults.

  • 0 views
  • 11 Apr, 2021
  • 2 locations