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Found 126 clinical trials
Fetoscopic Repair of Isolated Fetal Spina Bifida

The purpose of this investigation is to evaluate maternal and fetal outcomes following fetoscopic repair of fetal spina bifida at the Johns Hopkins Hospital. The hypothesis of this study is that fetoscopic spina bifida repair is feasible and has the same effectiveness as open repair of fetal spina bifida, but …

open repair
uterine rupture
fetoscopy
prenatal
fetal spina bifida
  • 41 views
  • 15 Oct, 2021
  • 1 location
Milrinone in Congenital Diaphragmatic Hernia

Infants with congenital diaphragmatic hernia (CDH) usually have pulmonary hypoplasia and persistent pulmonary hypertension of the newborn (PPHN) leading to hypoxemic respiratory failure (HRF). Pulmonary hypertension associated with CDH is frequently resistant to conventional pulmonary vasodilator therapy including inhaled nitric oxide (iNO). Increased pulmonary vascular resistance (PVR) can lead to …

nitric oxide
arterial blood gas
diaphragmatic hernia
vasodilator
hypertension
  • 73 views
  • 03 Nov, 2021
  • 16 locations
Tenofovir Disoproxil Fumarate in Combination of Hepatitis B Vaccine for Preventing Hepatitis B Vertical Transmission

Immunoprophylaxis with two hepatitis B vaccinations following the hepatitis B immune globulin (HBIg) and hepatitis B vaccine at birth is largely effective in protecting infants from hepatitis B virus (HBV) infection. However, hepatitis B infection due to immunoprophylaxis failure often occurs in approximately 10% of infants who are born to …

tenofovir
hepatitis
vaccination
tenofovir disoproxil fumarate
fumarate
  • 81 views
  • 23 Jan, 2021
  • 9 locations
Chinese Medicine WT for Spinocerebellar Ataxia Type 3

effective treatment or palliative methods for patients in the present days. However, low-dose growth hormone, or its downstream product, insulin-like growth factor I (IGF-1), may deter the progress of SCA3

  • 3 views
  • 01 Nov, 2021
  • 1 location
Enteral Zinc to Improve Growth in Infants at Risk for Bronchopulmonary Dysplasia

critical role in growth, through its actions on growth hormone, IGF-1, IGFBP-3, and bone metabolism. Prematurity is a risk factor for zinc deficiency, as 60% of zinc accretion occurs in the third trimester

very low birth weight
severe bronchopulmonary dysplasia
zinc
prematurity
  • 4 views
  • 14 Jan, 2022
  • 2 locations
Subcutaneous Hydrocortisone Children With Congenital Adrenal Hyperplasia

This is an open-label, non-randomized crossover design feasibility trial comparing oral hydrocortisone treatment with interval bolus delivery (pulsatile) of subcutaneous hydrocortisone via infusion pump in children with congenital adrenal hyperplasia. Eight children, ages 4-18 yrs, will have 24-hr pharmacokinetic and pharmacodynamic profiles of cortisol, 17-hydroxyprogesterone and androstenedione concentrations while on …

classic congenital adrenal hyperplasia
androstenedione
glucocorticoid therapy
epinephrine
oral hydrocortisone
  • 29 views
  • 16 Sep, 2021
  • 1 location
Fetal Endoscopic Surgery for Spina Bifida

This study aims to assess the feasibility to perform a fetoscopic prenatal repair of an open neural tube defect, and secondly to assess the maternal, fetal and neonatal outcomes.

neural tube defect
endoscopic surgery
prenatal
  • 11 views
  • 21 Jan, 2021
Renal Anhydramnios Fetal Therapy

Early pregnancy renal anhydramnios or EPRA is a condition where a pregnant woman does not have any amniotic fluid around her fetus because of a problem with the fetus's kidneys. This condition is thought to be fatal once the fetus is born because of inadequate lung growth. The Renal Anhydramnios …

prenatal
early pregnancy
  • 214 views
  • 17 Dec, 2021
  • 10 locations
Safety and Efficacy Study of reSept ASD Occluder for Treating Secundum ASD

Evaluation of the safety and efficacy of the reSept ASD Occluder to treat patients with clinically significant secundum atrial septal defect

aspirin
  • 0 views
  • 03 Dec, 2021
  • 11 locations
Contribution of Dolutegravir to Obesity and Cardiovascular Disease

The goal of the study is to combine a collaborative and translational approach to evaluate the effect antiretroviral regimen switch to a dolutegravir containing regimen compared to continued treatment with a non- dolutegravir based regimen on on lipid and metabolic profiles, renal function, body composition, vascular function and diet.

  • 0 views
  • 02 Feb, 2021
  • 1 location