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Found 110 clinical trials
Realization of Sequencing of All Known Human Genes in Case of Detection of Cerebral Renal or Ophthalmological Fetal Malformations During Pregnancy in Order to Make an Etiological Diagnosis and to Precise the Fetal Prognosis

Congenital malformations concern 3% of pregnancies; most of them can be seen during pregnancy. For some malformations, an invasive sample (trophoblast biopsy or amniocentesis) is proposed to search a chromosomal abnormality by the technique of DNA chip. However, some strongly suggestive signs of a genetic (and not chromosomal) pathology have …

  • 0 views
  • 26 Jan, 2021
  • 12 locations
Trial of Fetoscopic Endoluminal Tracheal Occlusion (FETO)

The rationale for fetal therapy in severe congenital diaphragmatic hernia (CDH) is to restore adequate lung growth for neonatal survival.

pulmonary hypoplasia
fetal therapy
diaphragmatic hernia
  • 0 views
  • 24 Jan, 2021
  • 1 location
Association of T Gamma Delta-CD16+ Cells and Anti-CMV Immunoglobulins in the Prevention of CMV Infection

> The humoral anti-CMV response is represented by the production of antibodies to envelope proteins (gB and gH) and to molecules involved in viral attachment and entry into target cells. However

kidney transplant
  • 0 views
  • 26 Nov, 2021
  • 1 location
Extended Criteria For Fetal Myelomeningocele Repair

The purpose of this study is to offer pre-natal Myelomeningocele (MMC) repair surgery to pregnant women with one of the former surgery exclusion factors A BMI of 35-40 kg/m2 Diabetes; patients will require good glycemic control History a previous preterm birth, as long as it was followed by a full …

repair of myelomeningocele
prenatal
amniocentesis
diabetes
prematurity
  • 24 views
  • 04 Jun, 2022
  • 2 locations
Bisphenol A and Muscle Insulin Sensitivity

This study examine oral bisphenol A consumption on muscle insulin sensitivity and hepatic glucose suppression. Half of the participants will receive a diet plus BPA and the other half will receive a diet plus no bisphenol A.

Accepts healthy volunteers
  • 0 views
  • 17 Feb, 2022
  • 1 location
Milrinone in Congenital Diaphragmatic Hernia

Infants with congenital diaphragmatic hernia (CDH) usually have pulmonary hypoplasia and persistent pulmonary hypertension of the newborn (PPHN) leading to hypoxemic respiratory failure (HRF). Pulmonary hypertension associated with CDH is frequently resistant to conventional pulmonary vasodilator therapy including inhaled nitric oxide (iNO). Increased pulmonary vascular resistance (PVR) can lead to …

arterial blood gas
pulmonary hypoplasia
diaphragmatic hernia
right ventricular overload
nitric oxide
  • 73 views
  • 03 Nov, 2021
  • 16 locations
Fetoscopic Repair of Isolated Fetal Spina Bifida

The purpose of this investigation is to evaluate maternal and fetal outcomes following fetoscopic repair of fetal spina bifida at the Johns Hopkins Hospital. The hypothesis of this study is that fetoscopic spina bifida repair is feasible and has the same effectiveness as open repair of fetal spina bifida, but …

uterine rupture
prenatal
fetoscopy
open repair
fetal spina bifida
  • 41 views
  • 25 Feb, 2022
  • 1 location
Tenofovir Disoproxil Fumarate in Combination of Hepatitis B Vaccine for Preventing Hepatitis B Vertical Transmission

Immunoprophylaxis with two hepatitis B vaccinations following the hepatitis B immune globulin (HBIg) and hepatitis B vaccine at birth is largely effective in protecting infants from hepatitis B virus (HBV) infection. However, hepatitis B infection due to immunoprophylaxis failure often occurs in approximately 10% of infants who are born to …

tenofovir
hepatitis
mother-to-child transmission
hbeag
vaccination
  • 81 views
  • 02 Mar, 2022
  • 7 locations
Renal Anhydramnios Fetal Therapy (RAFT)

Early pregnancy renal anhydramnios or EPRA is a condition where a pregnant woman does not have any amniotic fluid around her fetus because of a problem with the fetus's kidneys. This condition is thought to be fatal once the fetus is born because of inadequate lung growth. The Renal Anhydramnios …

prenatal
early pregnancy
  • 255 views
  • 12 Aug, 2022
  • 9 locations
Fetal Endoscopic Surgery for Spina Bifida

This study aims to assess the feasibility to perform a fetoscopic prenatal repair of an open neural tube defect, and secondly to assess the maternal, fetal and neonatal outcomes.

prenatal
endoscopic surgery
neural tube defect
  • 11 views
  • 21 Jan, 2021