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Found 84 clinical trials
A Study to Evaluate the Safety and Efficacy of Paltusotine for the Treatment of Acromegaly

A randomized, placebo-controlled study designed to evaluate the safety and efficacy of paltusotine (formerly CRN00808; an oral selective nonpeptide somatostatin receptor type 2 biased agonist

somatostatin
igf1
insulin-like growth factor
  • 0 views
  • 13 Aug, 2021
  • 4 locations
An Open Label Registry Study of Lutetium-177 (DOTA0 TYR3) Octreotate (Lu-DOTA-TATE) Treatment in Patients With Somatostatin Receptor Positive Tumours

progression free survival; induce a (good) partial remission and induce a complete remission in patients with a somatostatin receptor positive tumour. The purpose of this study is to assess the

neuroendocrine tumor
lu-dota-tate
dotatate
somatostatin
  • 63 views
  • 26 Jan, 2021
  • 1 location
Estrogen Treatment in Acromegalic Women

Oral estrogens may be an effective adjuvant treatment for control of acromegaly in patients with resistance to somatostatin analogs.

somatostatin
  • 29 views
  • 07 Nov, 2020
  • 1 location
Treatment of the Dumping Syndrome With Lanreotide Autogel

Background Somatostatin and octreotide LAR (long-acting analogue) exert a number of inhibitory effects: on gut hormones, but also on gastro-intestinal secretion and motility

  • 0 views
  • 07 Nov, 2020
  • 1 location
Acromegaly Combination Treatment Study

In this study the investigators will evaluate whether combination low dose somatostatin receptor ligand (SRL) and weekly or daily Pegvisomant will attain equivalent control of serum IGF-1 levels

somatostatin
octreotide
lfts
dopamine
medical therapy
  • 114 views
  • 25 Jan, 2021
  • 1 location
Randomized Evaluation of Octreotide Versus Compazine for Emergency Department Treatment of Migraine Headache

headaches would have no addictive properties, few side effects, quick onset, be highly effective and have a low rate of recurrence. Somatostatin is known to have an inhibitory effect on a

vomiting
sumatriptan
nausea
dihydroergotamine
pain relief
  • 286 views
  • 07 Nov, 2020
  • 1 location
Exploration of Molecular Biomarkers for Lu-177 DOTATATE Therapy in Midgut Neuroendocrine Tumor

somatostatin receptors, is an internal vectorized radiotherapy using Lu-177, an ideal radionuclide for peptide radionuclide therapy. In NETTER-1 phase III randomized clinical trial, Lu-177 Dotatate proved its

  • 0 views
  • 26 Jan, 2021
A Trial to Assess the Safety and Effectiveness of Lutetium-177 Octreotate Therapy in Neuroendocrine Tumours

-DOTA-TATE treatment in patients with somatostatin receptor positive tumours; 2) assess the safety of Lu-DOTA-TATE; 3) assess the effect of Lu-DOTA-TATE on Quality of Life and survival.

cancer
l-arginine
lu-dota-tate
somatostatin
18f-fdg
  • 17 views
  • 22 Apr, 2021
  • 1 location
Targeted Therapy and Avelumab in Merkel Cell Carcinoma

10.17 GoTHAM is intended as a signal-seeking, biomarker, phase Ib/II study that will evaluate the safety and anti-tumour activities of the novel combination of avelumab with 177-Lu-DOTATATE (a type of peptide receptor radionuclide therapy; PRRT) or external beam radiation therapy (EBRT) in patients with metastatic Merkel cell carcinoma (mMCC).

  • 0 views
  • 29 Apr, 2021
  • 6 locations
Effect of Intratumoral Injection of Gene Therapy for Locally Advanced Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDAC) is the fifth leading cause of cancer-related death in Western countries, and its incidence has increased over the last 40 years. Curative surgery to manage PDAC is possible in only a fraction of patients; indeed, a vast majority (85%) of patients is diagnosed with locally advanced …

cancer
pancreatic ductal adenocarcinoma
ductal adenocarcinoma
pdac
gemcitabine
  • 27 views
  • 24 Jan, 2021
  • 10 locations