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Found 2038 clinical trials
YIV-906 (Formerly PHY906/KD018) With Sorafenib in HBV(+) Hepatocellular Carcinoma (HCC)

The aim of this study is to compare the efficacy and safety of YIV-906 plus standard-of-care sorafenib versus those of sorafenib alone as a first-line systemic treatment for patients with Hepatitis B (+) associated advanced hepatocellular carcinoma. YIV-906 (PHY906, KD018) is an immune system modulator. Clinical and preclinical research suggests …

  • 3 views
  • 04 Oct, 2022
  • 20 locations
First-in-human Study of M4076 in Advanced Solid Tumors (DDRiver Solid Tumors 410)

monotherapy in participants with solid tumors in dose escalation (Part 1A). Once the recommended dose for expansion (RDE) is declared in Part 1A, a preliminary food effect cohort, Part 1B, will follow at the

  • 0 views
  • 07 Oct, 2022
  • 2 locations
M1774 in Participants With Metastatic or Locally Advanced Unresectable Solid Tumors (DDRiver Solid Tumors 301)

This is an open-label, Phase I, first-in-human (FIH) multicenter, clinical study conducted in multiple parts to establish the safety, tolerability and Pharmacokinetic/Pharmacodynamic (PK/PD) profile (with and without food) and early signs of efficacy of M1774 as monotherapy and in combination with the poly (ADP-ribose) polymerase (PARP) inhibitor niraparib.

  • 1 views
  • 10 May, 2022
  • 4 locations
A Clinical Study of MIL93 in Solid Tumors.

MIL93 in Advanced or Metastatic solid tumors.

  • 0 views
  • 24 Mar, 2022
  • 1 location
NKG2D-CAR-NK92 Cells Immunotherapy for Solid Tumors

The purpose of this clinical investigation is to evaluate the safety and effects of NKG2D-CAR-NK92 infusions in the treatment of relapsed/refractory solid tumors.

  • 0 views
  • 07 Oct, 2022
  • 1 location
Treatment of Advanced and Metastatic Solid Tumors With MIL97

advanced or metastatic solid tumor. The study consists of a dose escalation phase and a dose expansion phase. An accelerated titration design (cohorts 1-2 only) followed by 3+3 dose-escalation design will

  • 0 views
  • 04 Oct, 2022
  • 1 location
A Study of KC1036 in Patients With Advanced Solid Tumors

The purpose of this study is to evaluate the safetytolerability, pharmacokinetics, and preliminary efficacy of KC1036 in participants with advanced recurrent or metastatic solid tumors. The

  • 0 views
  • 22 Aug, 2021
  • 3 locations
Arsenic Trioxide in Refractory Solid Tumors With Rescuable p53 Mutation

This study is an open, prospective, single arm, multi center exploratory basket clinical study. 20 refractory solid tumors patients with rescuable p53 mutation will be enrolled, and the efficacy

  • 0 views
  • 24 May, 2021
  • 1 location
A Phase I Study of AL8326 in Advanced Solid Tumor

Main purpose Objective to study the tolerance and safety of single and multiple administration of repeated 28-day cycles of AL8326 in patients with advanced solid tumor, observe the dose

  • 0 views
  • 24 May, 2021
  • 2 locations
MRI in Diagnosing Solid Tumors of the Eye and Orbit

This study is being done due to a new imaging method that may help others in the future to improve evaluation of diseases in the eye and eye socket and to help make a decision concerning best treatment of the disease. Previous studies suggests that dynamic contrast enhanced MRI is …

  • 10 views
  • 28 Apr, 2022
  • 1 location