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Found 1709 clinical trials
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A Phase 1/1b Study of Sitravatinib in Combination with Nivolumab and Ipilimumab in Patients with Advanced or Metastatic Clear-Cell Renal Cell Carcinoma or Other Solid Malignancies

and ipilimumab for the treatment of ccRCC and potentially other solid tumor types. Sitravatinib is a spectrum-selective receptor tyrosine kinase (RTK) inhibitor that inhibits several closely

nivolumab
ipilimumab
VEGFR2
carcinoma
tyrosine
  • 27 views
  • 15 Sep, 2020
  • 1 location
featured
Alliance A071701 Genomically-Guided Treatment Trial in Brain Metastases

People with recurrent or progressive brain metastases may be eligible for this trial.  All tumors will be submitted to the Alliance biorepository for tracking and processing.  Samples will undergo central biomarker testing.  Patient's tumor samples will be tested for the presence of mutations predicting sensitivity to each inhibitor.  Patients harboring …

solid tumors
brain tumors
brain tumor
brain metastases
solid tumor
  • 40 views
  • 22 Dec, 2020
  • 1 location
featured
A Multicenter, Open-Label, Randomized, Phase 3 Trial to Compare the Efficacy and Safety of Lenvatinib in Combination with Everolimus or Pembrolizumab Versus Sunitinib Alone in First Line Treatment of Subjects with Advanced Renal Cell Carcinoma

A Multicenter, Open-Label, Randomized, Phase 3 Trial to Compare the Efficacy and Safety of Lenvatinib in Combination with Everolimus or Pembrolizumab Versus Sunitinib Alone in First Line Treatment of Subjects with Advanced Renal Cell Carcinoma

  • 220 views
  • 08 Nov, 2020
  • 1 location
featured
Prevention of venous thromboembolism (VTE) in cancer patients at high risk for VTE and who are undergoing chemotherapy

Prevention of venous thromboembolism (VTE) in cancer patients at high risk for VTE and who are undergoing chemotherapy

  • 114 views
  • 08 Nov, 2020
  • 1 location
featured
ANBL00B1: Biomarkers in Tumor Tissue Samples from Patients with Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma

ANBL00B1: Biomarkers in Tumor Tissue Samples from Patients with Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma

  • 104 views
  • 08 Nov, 2020
  • 1 location
AMG 404 in Patients With Advanced Solid Tumors.

To evaluate the safety and tolerability of AMG 404, a monoclonal antibody that binds to PD-1 and inhibits its engagement with ligands, in patients with advanced solid tumors.

  • 87 views
  • 07 Mar, 2021
  • 19 locations
A Study of the Effects of ALKS 4230 on Subjects With Solid Tumors

To better understand the safety and tolerability of ALKS 4230 in humans

  • 0 views
  • 26 Jan, 2021
  • 25 locations
A Study of BLZ945 Single Agent or BLZ945 in Combination With PDR001 in Advanced Solid Tumors

), pharmacodynamics, and anti-tumor activity of BLZ945, administered orally, as a single agent or in combination with PDR001, administered intravenously (i.v.) in adult patients with advanced solid tumors.

  • 0 views
  • 04 Mar, 2021
  • 18 locations
  • 1 views
  • 07 Mar, 2021
  • 8 locations
Study of AMG 650 in Adult Participants With Advanced Solid Tumors

To evaluate the safety and tolerability of AMG 650 in adult participants and to determine the maximum tolerated dose (MTD) and/or recommended phase 2 dose (RP2D).

  • 17 views
  • 07 Mar, 2021
  • 21 locations