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Found 171 clinical trials
Induced Pluripotent Stem Cells for Disease Research

screening of small molecule drugs capable of reversing the disease phenotype and potentially leading to a cure for a broad range of diseases, where appropriate in vitro or in vivo disease models do not

  • 0 views
  • 27 Jan, 2021
  • 1 location
Food Antigen in Eosinophilic Esophagitis

The relationship or effect of food antigen (wheat based soy sauce) in eosinophilic esophagitis. It is believed that when food antigens are exposed to the esophageal tissue it starts an chronic allergy-based inflammation. This will be analyzed with the esophageal biopsies and the mucosal impedance probe.

proton pump inhibitors
  • 5 views
  • 25 Jan, 2021
  • 1 location
Comparative Effectiveness of Targeted Therapy in RA Patients

The objective of a multicenter prospective observational study is to compare effectiveness and safety of biologic disease-modifying antirheumatic drugs and small molecular inhibitors in patients with moderately to severely active rheumatoid arthritis patients who have had an inadequate response or intolerace to methotrexate.

tocilizumab
abatacept
tofacitinib
DMARD
etanercept
  • 0 views
  • 24 Jan, 2021
  • 1 location
Natural History of Medullary Thyroid Cancer to Inform Advanced Disease Management

This study utilizes a multi-institutional registry to describe the natural history of medullary thyroid cancer that has spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) in understanding disease management. The goal of this study is to learn about how medullary …

  • 0 views
  • 25 Jan, 2021
  • 1 location
Collection of Blood in Studying Metabolites in Patients With Prostate Cancer

This pilot research trial utilizes the collection of blood in studying metabolites in patients with prostate cancer. Metabolites are the small molecule products of cellular metabolism that are

  • 0 views
  • 23 Jan, 2021
  • 1 location
Breath Biomarkers for Sleep Loss and Circadian Timing

technology, small molecule analysis (e.g. metabolomics), to detect compounds in breath that reliably change with sleep-wake state and those whose levels vary by time of day.

  • 0 views
  • 18 Mar, 2021
  • 1 location
Abemaciclib in Combination With Endocrine Therapy as First Line Therapy in Metastatic Breast Cancer Patients With Symp-tomatic Visceral Metastases or High Tumor Burden

-coming de novo or acquired resistance to ET in metastatic breast cancer has led to the integration of CDK4/6 inhibitors into combined ET of MBC. Abemaciclib represents a selective and potent small

  • 0 views
  • 31 Jan, 2021
  • 1 location
Trajectory of Microbiota Maturation in Healthy Bern Infants - a Network Approach

acid (mRNA) analysis will inform about metabolic potential and metabolic activity of the microbiota. Mass spectrometry will assess the small molecule content of stool and maternal milk samples. Network

  • 0 views
  • 24 Jan, 2021
  • 1 location
Fecal Metabolome and the Intestinal Microbiota in Irritable Bowel Syndrome

The purpose of this study is to find out the relationship between the bile acids, fatty acids (fatty acids are part of the diet) and bacteria that are present in the intestines.

fatty acids
gluten
bile acid
fodmap diet
microbiota
  • 134 views
  • 16 Feb, 2021
  • 1 location
Complement C5a Receptors in Hidradenitis Suppurativa

To study the role of C5a in Hidradenitis Suppurativa (HS). Complement C5a is a major chemotactic factor that stimulates neutrophil infiltration.

hidradenitis
  • 50 views
  • 13 Feb, 2021
  • 1 location