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Found 30 clinical trials
International Severe Asthma Registry: Canadian Cohort (ISAR)

The International Severe Asthma Registry is a global initiative looking to ensure that the care of people with severe asthma will continue to improve by collecting detailed information about the health and treatment of as many people with the disease as possible. The study will gather anonymized longitudinal real-life data …

  • 15 Feb, 2022
  • 4 locations
Re-Introducing Nuts in Allergic Patients (ReINA)

This study aims to compare the safety and the compliance to different procedures (A: at home or B: at the hospital) for introducing tree nuts into the diet of patients with Immunoglobulin E (IgE)-mediated allergy to the aforementioned nuts. In parallel, the effectiveness of tree nuts' introduction in respect to …

  • 17 Feb, 2022
  • 1 location
Impact of Early Lung Physiology, Viral Infections and the Microbiota on the Development and Progression of Lung Disease in Children With Cystic Fibrosis (SCILD)

This study collects data on microbiological factors and lung function parameters (e.g. spirometry, body plethysmography, lung-MRI) to assess their interaction on the lung growth and lung development of infants and children with Cystic Fibrosis (CF).

  • 12 Feb, 2022
  • 1 location
Natural History and Genetics of Food Allergy and Related Conditions

will be screened with medical history, physical exam, and questionnaires. Participants may have the following: Blood tests Allergy skin prick tests: Drops of allergens

food allergy
prick skin
Accepts healthy volunteers
  • 15 May, 2022
  • 1 location
Natural History of Severe Allergic Inflammation and Reactions

as part of this study: A detailed physical examination and medical history Allergy skin prick testing to examine participants' responses to different allergens.

food allergy
hay fever
skin prick
Accepts healthy volunteers
  • 13 May, 2022
  • 1 location
Follow up of LEAP Participants and Their Families

This prospective, cross-sectional study is designed to improve understanding of how early-life introduction of peanuts may promote the development of tolerance at 12 years of age and will serve as an additional safety evaluation of this nutritional intervention.

skin pricking
  • 04 Mar, 2022
  • 1 location
Biomarkers in Nasal Samples of Seasonal Allergic Rhinitics

The purpose of this study is to analyze nasal samples for the presence of biomarkers of allergic inflammation as well as cold and flu infections, and compare these samples both in and out of an individual's active allergy season. 40 subjects who suffer from seasonal allergies will be recruited and …

  • 14 May, 2021
  • 1 location
Detection of Metabolite Biomarkers for the Early Diagnosis and Prognosis of Cow's Milk Allergy in Children

In this study, fecal and urine samples will be collected from children diagnosed with : IgE mediated cow's milk allergy, suspected of a cow's milk allergy, but with negative diagnosis IgE mediated food allergy other than cow's milk healthy brothers and sisters of the first three groups A subset of …

food allergy
Accepts healthy volunteers
allergy in children
milk allergy
early diagnosis
  • 25 Feb, 2022
  • 7 locations
Small Airways Disease (SAD) in Severe Asthma as a Novel Endpoint and Distinct Target for Mepolizumab (SASAM Study)

Rationale Although the majority of asthma patients can be effectively treated with currently available medications, a substantial subset remains severe, causing a considerable proportion of resource expenditure. Severe asthma is now widely accepted to be a heterogeneous syndrome consisting of multiple phenotypes identified by specific biomarkers and targeted by tailored …

  • 17 Sep, 2021
  • 1 location
Efficacy of Mepolizumab in Severe Asthmatics (MESILICO)

Interleukin (IL)-5 is the main cytokine responsible for the activation of eosinophils, hence therapeutic strategies have been investigated and developed for clinical use. Biologics targeting IL-5 and its receptor (first mepolizumab and subsequently, reslizumab and benralizumab), have been recently approved and used as add-on therapy for severe eosinophilic asthma resulting …

  • 30 Jan, 2021
  • 1 location