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Found 4447 clinical trials
Safety and Efficacy of CEA-Targeted CAR-T Therapy for Relapsed/Refractory CEA+ Cancer

This is a single arm study to evaluate the efficacy and safety of CEA-targeted CAR-T cells therapy for patients with relapsed/refractory CEA+ Cancer,and obtain the recommended dose and infusion plan.

neutrophil count
targeted therapy
cancer chemotherapy
total bilirubin
kidney function test
  • 0 views
  • 04 Mar, 2022
  • 1 location
Study of NEO-201 in Solid Tumors Expansion Cohorts

The open label, first-in-human, phase 1, dose escalation component in refractory solid tumors has been completed. The Maximum Tolerated Dose and Recommended Phase 2 Dose (RP2D) was determined to be 1.5mg/kg. The Expansion Phase of this study is currently enrolling subjects with non small cell lung cancer (NSCLC), head and …

karnofsky performance status
breast cancer
measurable disease
BRAF
neuropathy
  • 45 views
  • 23 Apr, 2022
  • 1 location
Implementation and Quality Assurance of DPYD-genotyping in Patients Treated With Fluoropyrimidines.

The purpose of this study is to examine the benefits of a clinical implementation of a DPYD-genotype test to patients starting treatment with fluoropyrimidines (Fluorouracil (5-FU), capecitabine, tegafur).

fluorouracil
fluoropyrimidine
capecitabine
tegafur
  • 0 views
  • 10 Mar, 2022
A Study of JAB-3312 in Adult Patients With Advanced Solid Tumors in China

This is a Phase 1, open-label dose-escalation study to determine the maximum tolerated dose (MTD) and/or recommended Phase 2 dose (RP2D) and assess the DLT of JAB-3312. It is anticipated that approximately 24 subjects will be enrolled in the dose-escalation phase of the study. JAB-3312 will be administered orally once …

measurable disease
solid tumour
solid tumors
mammogram
  • 0 views
  • 05 Jan, 2022
  • 1 location
A Study of TAK-500 With or Without Pembrolizumab in Adults With Select Locally Advanced or Metastatic Solid Tumors

This study is about TAK-500, given either alone or with pembrolizumab, in adults with select locally advanced or metastatic solid tumors. The aims of the study are: to assess the safety profile of TAK-500 when given alone and when given with pembrolizumab. to assess the effects of TAK-500, when given …

neutrophil count
pancreatic adenocarcinoma
adenocarcinoma
lung cancer
alopecia
  • 0 views
  • 25 May, 2022
  • 1 location
Study of CBX-12 in Subjects With Advanced or Metastatic Refractory Solid Tumors

This is a first-in-human, Phase 1/2 open-label, multicenter, dose-escalation, safety, pharmacokinetics (PK), and biomarker study of CBX-12 in subjects with advanced or metastatic refractory solid tumors.

  • 0 views
  • 30 May, 2022
  • 4 locations
Biospecimen Collection in Identifying Genetic Changes in Patients With Breast, Prostate, Colorectal, Liver, or Kidney Cancer or Multiple Myeloma Undergoing Surgery

This research trial studies how well biospecimen collection works in identifying genetic changes in patients with breast, prostate, colorectal, liver, or kidney cancer or multiple myeloma undergoing surgery. Studying samples collected during surgery may add to the understanding of cancer by looking for the genetic changes that cause early cancer …

invasive carcinoma
breast cancer
systemic therapy
kidney cancer
cancer
  • 0 views
  • 15 Jun, 2022
  • 1 location
HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

This study is a clinical trial to determine the safety of inoculating G207 (an experimental virus therapy) into a recurrent or refractory cerebellar brain tumor. The safety of combining G207 with a single low dose of radiation, designed to enhance virus replication, tumor cell killing, and an anti-tumor immune response, …

biologic agents
anaplastic astrocytoma
rhabdoid tumor
aptt
giant cell glioblastoma
  • 84 views
  • 18 Jun, 2022
  • 1 location
Study With Bispecific Antibody Engaging T-cells, in Patients With Progressive Cancer Diseases With Positive PSCA Marker

This dose-escalating phase I trial assesses for the first time the safety, the side effects and the harmlessness, as well as the therapeutical benefit of the new study drug GEM3PSCA in patients with prostate stem cell antigen (PSCA) expressing cancer types which failed to respond to standard therapy.

ejection fraction
measurable disease
solid tumour
solid tumors
cancer
  • 7 views
  • 03 Feb, 2022
  • 5 locations
The Genomic Medicine at VA Study

This trial will determine the clinical effectiveness of polygenic risk score testing among patients at high genetic risk for at least one of six diseases (coronary artery disease, atrial fibrillation, type 2 diabetes mellitus, colorectal cancer, breast cancer, or prostate cancer), measured by time-to-diagnosis of prevalent or incident disease over …

type 2 diabetes mellitus
diagnostic procedure
breast cancer
cancer
fibrillation
  • 163 views
  • 12 Aug, 2021
  • 1 location