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Found 441 clinical trials
A Study of Ladiratuzumab Vedotin in Advanced Solid Tumors

This trial will study ladiratuzumab vedotin (LV) to find out if it works to treat different types of solid tumors. It will also find out what side effects may occur. A side effect is anything the drug does besides treating cancer.

systemic therapy
melanoma skin
immunologic adjuvant
cancer chemotherapy
chemoradiotherapy
  • 13 views
  • 14 Jun, 2022
  • 64 locations
MGC018 With or Without MGA012 in Advanced Solid Tumors

The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics (PK) pharmacodynamics and preliminary antitumor activity of MGC018 administered alone and in combination with MGA012 in patients with advanced solid tumors.

systemic therapy
cancer chemotherapy
cancer
hormone therapy
solid tumour
  • 18 views
  • 12 Mar, 2022
  • 19 locations
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic …

immunodeficiency
systemic therapy
mammogram
dabrafenib
cancer chemotherapy
  • 6575 views
  • 27 Jun, 2022
  • 913 locations
First Time in Human Study of AZD8701 With or Without Durvalumab in Participants With Advanced Solid Tumours

The purpose of this study is to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Immunogenicity and Antitumor Activity of AZD8701 Alone and in Combination with Durvalumab (MEDI4736) in Adult Subjects with Select Advanced Solid Tumors

lung carcinoma
breast cancer
triple negative breast cancer
durvalumab
monoclonal antibodies
  • 52 views
  • 09 Jun, 2022
  • 12 locations
A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors (NAVIGATE)

This research study is done to test how well different types of cancer respond to the drug called larotrectinib. The cancer must have a change in a particular gene (NTRK1, NTRK2 or NTRK3). Larotrectinib is a drug that blocks the actions of these NTRK genes in cancer cells and can …

lung carcinoma
breast cancer
measurable disease
lung cancer
NTRK
  • 162 views
  • 14 Jun, 2022
  • 129 locations
Study of CB-103 in Adult Patients With Advanced or Metastatic Solid Tumours and Haematological Malignancies

This is a phase I/II, non randomized, open-label, dose escalation study to investigate the safety, tolerability and preliminary efficacy of CB-103.

amylase
systemic therapy
t-cell lymphoma
mammogram
metastatic disease
  • 286 views
  • 25 Mar, 2022
  • 14 locations
Evaluation of the Length of Treatment With PD-1/PD-L1 Inhibitors in Patients With Advanced Solid Tumors

Based on the overwhelming positive response to this survey and the large number of patients being treated with PD-1/PD-L1 therapy in the UPMC system, the investigators are proposing a trial that will randomize patients who have disease stability to stop treatment at 1 year or continue treatment until disease progression. …

atezolizumab
breast cancer
durvalumab
nivolumab
cancer chemotherapy
  • 53 views
  • 26 Mar, 2022
  • 1 location
Study of SO-C101 and SO-C101 in Combination With Pembro in Adult Patients With Advanced/Metastatic Solid Tumors

A multicenter open-label phase 1/1b study to evaluate the safety and preliminary efficacy of SO-C101 as monotherapy and in combination with pembrolizumab in patients with selected advanced/metastatic solid tumors

neuropathy
cancer chemotherapy
biological factors
biologic agents
alopecia
  • 43 views
  • 30 Apr, 2022
  • 7 locations
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099318 in Participants With Advanced Solid Tumors

The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics, and pharmacodynamics of INCB099318 in select solid tumors.

  • 0 views
  • 11 Mar, 2022
  • 21 locations
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099280 in Participants With Advanced Solid Tumors

The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics, pharmacodynamics, and early clinical activity of INCB099280 in participants with select solid tumors

solid tumour
solid tumors
  • 20 views
  • 19 Jun, 2022
  • 16 locations