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Found 441 clinical trials
Dabrafenib and/or Trametinib Rollover Study

This study is to provide access for patients who are receiving treatment with dabrafenib and/or trametinib in a Novartis-sponsored Oncology Global Development, Global Medical Affairs or a former GSK-sponsored study who have fulfilled the requirements for the primary objective, and who are judged by the investigator as benefiting from continued …

dabrafenib
trametinib
  • 87 views
  • 29 Jun, 2022
  • 16 locations
Phase 1 Study of CK-301 (Cosibelimab) as a Single Agent in Subjects With Advanced Cancers

CK-301 (cosibelimab) is a fully human monoclonal antibody of IgG1 subtype that directly binds to Programmed Death-Ligand 1 (PD-L1) and blocks its interactions with the Programmed Death-1 (PD-1) and B7.1 receptors. The primary objectives of this study are to assess the safety, tolerability and efficacy of CK-301 when administered intravenously …

metastasis
squamous cell carcinoma of head and neck
hodgkin's disease
stage iv non-small cell lung cancer
metastatic melanoma
  • 2166 views
  • 10 Mar, 2022
  • 26 locations
Family History App in Personalized Medicine

A complete family history (FH) may identify persons at high risk for certain conditions. They can be offered genetic testing and life-saving screening and treatment. In practice, complete FH is rarely collected or entered into the electronic medical record (EMR). The Family History Screening Questionnaire is a survey patients complete …

cancer
Accepts healthy volunteers
heart disease
precision medicine
  • 0 views
  • 10 Oct, 2021
  • 1 location
MGD019 DART® Protein in Unresectable/Metastatic Cancer

The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics (PK) pharmacodynamics and preliminary antitumor activity of lorigerlimab. This Phase 1, open-label study will characterize safety, dose-limiting toxicities (DLTs), and maximum tolerated/administered dose (MTD/MAD) of MGD019. Dose escalation will occur in a 3+3+3 design in patients with …

cancer
systemic therapy
metastasis
formalin-fixed paraffin-embedded
solid neoplasm
  • 18 views
  • 13 May, 2022
  • 29 locations
A Study of SGN-CD228A in Advanced Solid Tumors

This trial will study SGN-CD228A to find out whether it is an effective treatment for different kinds of cancer. It will also look at what side effects (unwanted effects) may occur. The study will have two parts. Part 1 of the study will find out how much SGN-CD228A should be …

cancer
metastasis
adenocarcinoma
pemetrexed
pd-l1
  • 16 views
  • 13 May, 2022
  • 14 locations
SL-279252 (PD1-Fc-OX40L) in Subjects With Advanced Solid Tumors or Lymphomas

This is a Phase 1 first in human, open label, multi-center, dose escalation and dose expansion study to evaluate the safety, tolerability, PK, anti-tumor activity and pharmacodynamic effects of SL-279252 in subjects with advanced solid tumors or lymphomas.

cancer
squamous cell cancers
hepatitis b core antibody
vasectomy
hodgkin's disease
  • 47 views
  • 25 Mar, 2022
  • 5 locations
Fluorescence for Sentinel Lymph Node Identification in Cancer Surgery (GASVERT)

This is a single-center prospective clinical trial to evaluate non-inferiority of indocyanine green guided sentinel lymph node biopsy compared with the gold standard Technecium99 guided sentinel lymph node biopsy in patients with cancers and subjected to surgery. The diagnostic performance and the tolerance of indocyanine green (ICG) to the radio-isotope …

cancer
sentinel lymph node biopsy
cancer surgery
indocyanine green
probe
  • 34 views
  • 27 Apr, 2022
  • 1 location
GEN1042 Safety Trial and Anti-tumor Activity in Subjects With Malignant Solid Tumors

To evaluate the safety and anti-tumor activity of GEN1042 in patients with metastatic or locally advanced solid tumors

systemic therapy
carboplatin
paclitaxel
pembrolizumab
measurable disease
  • 30 views
  • 21 Feb, 2022
  • 10 locations
Study of Safety and Efficacy of DKY709 Alone or in Combination With PDR001 in Patients With Advanced Solid Tumors.

This is a phase I/Ib, open label study. The escalation portion will characterize the safety and tolerability of DKY709 and DKY709 in combination with PDR001 in subjects with NSCLC or melanoma who have received prior anti-PD-1/PD-L1 therapy, or subjects with NPC. After the determination of the MTD/RD for a particular …

cancer
solid tumour
metastasis
programmed cell death 1 ligand 1
core needle biopsy
  • 141 views
  • 06 Jun, 2022
  • 8 locations
Stereotactic Body Radiotherapy in Patients With Rare Oligometastatic Cancers (OligoRARE) (OligoRARE)

This is a randomized open-label multicentre Phase III superiority study of the effect of adding SBRT to the standard of care treatment on overall survival in patients with rare oligometastatic cancers. Patients will be randomized in a 1:1 ratio between current standard of care treatment vs. standard of care treatment …

systemic therapy
brain metastases
metastasis
  • 0 views
  • 26 May, 2022
  • 7 locations