Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 459 clinical trials
How Microbes and Metabolism May Predict Skin Cancer Immunotherapy Outcomes (MINING)

The purpose of this research study is to examine the relationship between the microbiota (microscopic organisms) in the gut and the activity of the immune system during skin cancer immunotherapy

skin cancer
cancer
  • 32 views
  • 31 Jan, 2022
  • 1 location
Pathological Characteristics of Basal Cell Carcinoma

A hospital based cross-sectional study was conducted from 2017 to February 2021. Clinical history, examination and histopathological variants were collected from medical files and pathology reports. Confirmation of pathology was done in all the patients visiting skin and plastic surgery department with suspected lesions.

  • 0 views
  • 21 Jul, 2022
  • 1 location
Non-Linear Imaging of Skin In Vivo

The overall objective of this study is to investigate the potential for Enspectra Investigational Device to display microscopic skin structure in people of different age, sex, race, and skin health.

skin diseases
Accepts healthy volunteers
  • 0 views
  • 20 Jun, 2022
  • 1 location
Applicability of a Cellular Resolution Full-field OCT Image System for Pigmented and Non-pigmented Skin Tumors

The incidence of skin cancer has been continuously increasing over the past decades und the number of non melanoma skin cancer is well as melanoma is still going to increase. Invasive biopsy and

malignant melanoma of skin
melanoma skin
skin tumor
skin diseases
cancer
  • 0 views
  • 15 Nov, 2021
  • 1 location
Adjuvant Dabrafenib and Trametinib Treatment in Patients With Completely Resected High-risk Stage III Melanoma. (LEAD Melanoma)

Non-interventional (observational) cohort prospective real life study with primary and secondary data collection from patients on adjuvant treatment with dabrafenib + trametinib in patients with completely resected high-risk stage III (stage IIIA [lymph node > 1mm], IIIB, IIIC and IIID according to AJCC 8th edition) melanoma in Turkey.

immunologic adjuvant
melanoma skin
immunomodulators
stage iii melanoma
dabrafenib
  • 0 views
  • 16 Mar, 2022
  • 8 locations
Peripheral T Cell Determinants of Response and Resistance to Pembrolizumab in Melanoma

This is a non-therapeutic study assessing peripheral T cell determinants of response and resistance to immunotherapy in patients with advanced melanoma.The hypothesis is that systemic T cells traffic into the tumor microenvironment (TME) can predict response and resistance to immunotherapy. These systemic tumor directed T cells can be defined by …

advanced melanoma
measurable disease
metastatic melanoma
cancer
pembrolizumab
  • 0 views
  • 24 Nov, 2021
  • 1 location
Oral Hedgehog Inhibitors in the Treatment of Basal Cell Carcinoma in the Netherlands: a Prospective Registration Study

Background: Oral hedgehog inhibitors vismodegib and sonidegib have been used for the treatment of locally advanced (laBCC), metastatic basal cell carcinoma (mBCC) and in basal cell nevus syndrome (BCNS) patients. In the Netherlands, targeted therapy with vismodegib and sonidegib has been available since 2013 and 2021, respectively. No direct comparative …

carcinoma
nevus
targeted therapy
sonidegib
  • 0 views
  • 22 Jul, 2022
  • 6 locations
Predicting Response to Immunotherapy for Melanoma With Gut Microbiome and Metabolomics (PRIMM)

This study will investigate the effects of gut microbiome diversity (richness in terms of many bacterial species in the gut) on responses and side effects of immunotherapy in advanced melanoma patients. Immunotherapy for melanoma is especially damaging for the gut with colitis which can lead to death and significant morbidity …

advanced melanoma
cancer
  • 7 views
  • 13 Feb, 2022
  • 5 locations
Serial Tumour Biopsies and Blood Biomarkers in Melanoma

Recent advances in understanding how cancer develops and spreads have led to effective new treatments and improved outcomes for patients with melanoma. However, we know that these new treatments do not work for all patients: some do not respond to them and some initially respond but then develop resistance. The …

metastatic melanoma
advanced melanoma
cancer treatment
cancer
  • 0 views
  • 25 Jan, 2021
  • 1 location
BRAF-/MEK-Inhibition With Dabrafenib and Trametinib in Melanoma Patients (Combi-EU)

Adjuvant therapy with dabrafenib plus trametinib in melanoma was approved in 2018 by the EMA (EUropean Medicines Agency). The purpose of this non-interventional study is to assess the usage of adjuvant dabrafenib and trametinib in clinical practice, where the patient population may differ from study population.

immunologic adjuvant
melanoma skin
immunomodulators
BRAF
dabrafenib
  • 5 views
  • 25 Feb, 2022
  • 41 locations