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Found 445 clinical trials
The Impact of Melanoma and Drug Treatment in the Real World

An observational, non-interventional registry study to collect real-world data from people living with melanoma and its treatment, which will be available to researchers to further the knowledge of melanoma and improve patient care.

  • 7 views
  • 14 Oct, 2021
  • 1 location
Molecular Analysis of Childhood and Adolescent Melanocytic Lesions

This is an observational, non-therapeutic study to collect clinical and molecular information of pediatric patients with childhood melanocytic lesions. PRIMARY OBJECTIVE: To perform a comprehensive molecular analysis of samples either from paraffin embedded and/or frozen tissue from patients with pediatric melanocytic lesions (including melanoma, spitzoid melanoma, congenital melanoma, melanoma arising …

nevus
immunologic adjuvant
cancer
immunomodulators
  • 7 views
  • 24 Feb, 2022
  • 1 location
Tracing Dissemination of Melanoma Cells in Healthy Tissues (DISSEMELA)

The objective of this project is to evaluate the presence of melanoma quiescent or initiating clonal cells in peritumoral healthy tissue displaying the same molecular signature than those of the tumor/metastasis and to correlate this presence to the prognostic value.

metastasis
NRAS
BRAF
KIT
  • 10 views
  • 27 Feb, 2022
  • 1 location
Predicting Response to Immunotherapy for Melanoma With Gut Microbiome and Metabolomics (PRIMM)

This study will investigate the effects of gut microbiome diversity (richness in terms of many bacterial species in the gut) on responses and side effects of immunotherapy in advanced melanoma patients. Immunotherapy for melanoma is especially damaging for the gut with colitis which can lead to death and significant morbidity …

advanced melanoma
cancer
  • 7 views
  • 13 Feb, 2022
  • 5 locations
BRAF-/MEK-Inhibition With Dabrafenib and Trametinib in Melanoma Patients (Combi-EU)

Adjuvant therapy with dabrafenib plus trametinib in melanoma was approved in 2018 by the EMA (EUropean Medicines Agency). The purpose of this non-interventional study is to assess the usage of adjuvant dabrafenib and trametinib in clinical practice, where the patient population may differ from study population.

trametinib
melanoma skin
immunologic adjuvant
dabrafenib
cancer
  • 5 views
  • 25 Feb, 2022
  • 41 locations
Characterization of the Melanoma-Specific Immune Response (Melanoma)

The aim of this study is to study T-cells. Blood will be collected and the samples will be used to generate T cell clones. Two separate blood draws will be required at the maximum.

Accepts healthy volunteers
  • 14 views
  • 23 Jan, 2022
  • 1 location
Circulating Blood Profile to Predict Recurrence and Response to Systemic Therapy

To study if a targeted gene expression profile of RNA, similar to the NETest, can be isolated from the peripheral blood of patients with melanoma, to identify active disease, provide an assessment of treatment responses, or predict risk of relapse, in conjunction with standard clinical assessment and imaging.

metastatic melanoma
systemic therapy
  • 3 views
  • 10 Oct, 2021
  • 1 location
Effectiveness and Safety of Dabrafenib in Combination With Trametinib as Adjuvant Treatment for Chinese Patients With Stage III BRAF V600 Mutation-positive Melanoma After Complete Resection

This is a prospective, open label, single-arm, multicenter, non-interventional study of dabrafenib in combination with trametinib as adjuvant treatment for Chinese patients with stage III BRAF V600 mutation positive melanoma after complete resection.

trametinib
BRAF
immunomodulators
braf v600 mutation
immunologic adjuvant
  • 0 views
  • 08 Mar, 2022
  • 7 locations
Evolution of Metabolic and Immune Dysfunction in In-transit Melanoma

Melanoma in-transit metastases (ITMs) continue to represent a therapeutic dilemma, in that no standard method of treatment has been uniformly adopted. The complexity and heterogeneity of patient and disease characteristics, including the location and number of ITMs presents a barrier to a one size fits all treatment approach. Treatment of …

serum pregnancy test
tumor cells
systemic therapy
  • 0 views
  • 16 Mar, 2022
  • 1 location
Serial Tumour Biopsies and Blood Biomarkers in Melanoma

Recent advances in understanding how cancer develops and spreads have led to effective new treatments and improved outcomes for patients with melanoma. However, we know that these new treatments do not work for all patients: some do not respond to them and some initially respond but then develop resistance. The …

advanced melanoma
metastatic melanoma
cancer
cancer treatment
  • 0 views
  • 25 Jan, 2021
  • 1 location