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Found 457 clinical trials
Testing the Effects of MK-3475 (Pembrolizumab) With or Without the Usual Chemotherapy Treatment for Patients 70 Years of Age and Older With Advanced Non-small Cell Lung Cancer

This trial studies the side effects of pembrolizumab with or without chemotherapy in treating patients with stage IV non-small cell lung cancer that has come back (recurrent) and has spread to other places in the body (advanced). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system …

  • 06 May, 2022
  • 441 locations
An Observational Study to Evaluate Safety and Efficacy of Remsima™ in Patients With Ankylosing Spondylitis

An Observational, Prospective Cohort Study to Evaluate Safety and Efficacy of RemsimaTM in Patients with Ankylosing Spondylitis

  • 22 Jan, 2022
  • 1 location
Variable Anatomy and Function of the Arm's Alternate Lymphatic Pathway

Using indocyanine green (ICG) lymphography and lymphoscintigraphy with SPECT/CT imaging, the aim is to evaluate the anatomy of the lymphatic system pathway in two separate populations: healthy female volunteers and women with a history of breast cancer who did not develop lymphedema.

Accepts healthy volunteers
  • 19 Aug, 2022
  • 1 location
ARTIficial Intelligence-based Smartphone Application for Skin Cancer Detection (ARTIS)

The aim of this project is to assess whether a specific smartphone application (Skinvision App®) can be used as a tool to preselect skin lesions suspicious for skin cancer that require urgent

  • 09 Mar, 2022
  • 1 location
The Organ Transplant Recipient HPV and Skin Cancer Study

of skin cancer and cancers caused by human papillomavirus (HPV), including cervical cancer and oropharyngeal cancer. There is currently limited knowledge on risk factors for HPV infection and skin

human papillomavirus
hpv infection
  • 18 Apr, 2022
Research in the Development of a New Type of Digital Dermatoscope for Skin Cancer (DermScan)

This is a multicenter prospective observational clinical investigation with a medical device. The purpose of this study is to develop and validate of a new type of digital dermatoscope with automatic decision support algorithms. By means of this study a better insight can be gained of the current performance and …

skin cancer
skin lesion
  • 25 Jul, 2022
  • 2 locations
Implementation of Teledermoscopy and Artificial Intelligence

The study has 2 parts. Part 1 will investigate the effects of introducing teledermoscopy in clinical practice, more specifically the change in referral patterns, the risk of undetected skin

skin lesion
  • 22 Sep, 2021
  • 11 locations
MElanoma Research Lymph Node Prediction Implementation National_001 (MERLIN_001)

MERLIN_001 is a prospective registry study of a primary melanoma gene-signature to predict sentinel node (SN) status and to determine its prognostic value for more accurate staging of SN-negative melanoma patients.

melanoma skin
malignant melanoma of skin
  • 23 Mar, 2022
  • 8 locations
Predictive Clinical Features for Response to Adjuvant Immunotherapy in Stage II,III and IV Resected Melanoma (Mel-ImmAdj)

Surgical excision is the treatment of choice for stage II, III and resectable stage IV melanoma and is curative in most cases. Given the recent success of immunotherapy for the treatment of patients with advanced metastatic melanoma, the use of immunotherapy has been evaluated in the adjuvant setting for patients …

  • 22 Sep, 2022
  • 1 location
Examination of Clinical and Laboratory Abnormalities in Patients With Defective DNA Repair: Xeroderma Pigmentosum, Cockayne Syndrome, or Trichothiodystrophy

Four rare genetic diseases, xeroderma pigmentosum (XP), Cockayne syndrome (CS), the XP/CS complex and trichothiodystrophy (TTD) have defective DNA excision repair although only XP has increased cancer susceptibility. We plan to perform careful clinical examination of selected patients with XP, XP/CS, CS, or TTD and follow their clinical course. We …

cancer prevention
Accepts healthy volunteers
  • 19 Sep, 2022
  • 1 location