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Found 455 clinical trials
LITT and Pembrolizumab in Recurrent Brain Metastasis (TORCH)

This is an open-label, historically controlled pilot study investigating the immune effect of Laser Interstitial ThermotHerapy (LITT)+ pembrolizumab in adult patients with a primary cancer approved by the FDA for treatment with an immune-checkpoint inhibitor who have recurrent brain metastasis after prior stereotactic radiosurgery (SRS).

follicle stimulating hormone
gastric cancer
metastasis
hormone replacement
hysterectomy
  • 0 views
  • 04 Oct, 2022
  • 2 locations
Study of NGM120 in Subjects With Advanced Solid Tumors, Pancreatic Cancer, and Prostate Cancer Using Combination Therapy (PINNACLES)

Study of NGM120 in subjects with advanced solid tumors and and pancreatic cancer (Part 1 and 2) and metastatic castration resistant prostate cancer (Part 3).

metastatic pancreatic adenocarcinoma
pancreatic cancers
gastric cancer
immunomodulators
bladder cancer
  • 170 views
  • 07 Oct, 2022
  • 16 locations
A Phase 1/2, First-In-Human, Multi-Part, Open-Label, Multiple-Ascending Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, Biological, and Clinical Activity of DF6002 as a Monotherapy and in Combination With Nivolumab in Patients With Locally Advanced or Metastatic Solid Tumors, and Expansion in Selected Indications

The purpose of this study is to evaluate the safety, tolerability, drug-levels, drug-effects and preliminary anti-tumor activity of DF6002 (BMS-986415) alone and in combination with Nivolumab in participants with advanced solid tumors.

braf inhibitor
autoimmune disease
pd-l1
hodgkin's disease
immunomodulators
  • 75 views
  • 22 Oct, 2022
  • 48 locations
Focused Ultrasound Ablation and PD-1 Antibody Blockade in Advanced Solid Tumors (AM-003)

This study evaluates whether it is safe to Focused Ultrasound Ablation (FUSA) treatments with and without PD-1 blockade and with and without intratumoral poly-ICLC. A device called the Echopulse will be used for the FUSA therapy. Patients will be assigned to 1 of 2 cohorts depending on their disease and …

treatment regimen
metastasis
autoimmune disease
pd-l1
antibody therapy
  • 4 views
  • 07 Jul, 2022
  • 1 location
A Phase 1/2 Dose Escalation/Expansion Study of NGM707 as Monotherapy and in Combination With Pembrolizumab in Advanced or Metastatic Solid Tumor Malignancies

Study of NGM707 as Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumor Malignancies

pembrolizumab
  • 0 views
  • 17 Oct, 2022
  • 15 locations
A Study of XmAb®23104 in Subjects With Selected Advanced Solid Tumors (DUET-3) (DUET-3)

This is a Phase 1, multiple dose, ascending dose escalation study to define a MTD/RD and regimen of XmAb23104, to describe safety and tolerability, to assess PK and immunogenicity, and to preliminarily assess anti-tumor activity of XmAb23104 monotherapy and combination therapy with ipilimumab in subjects with selected advanced solid tumors.

treatment regimen
squamous cell carcinoma of head and neck
urothelial carcinoma
ipilimumab
formalin-fixed paraffin-embedded
  • 139 views
  • 06 Feb, 2022
  • 13 locations
Oral AMXT 1501 Dicaprate in Combination With IV DFMO

A Phase 1B/2A study will be conducted to establish safety and dose level of AMXT 1501 dicaprate in combination with IV DFMO, in cancer patients.

cancer
primary cancer
  • 6 views
  • 04 Oct, 2022
  • 1 location
A Phase 1/1b Dose Escalation/Expansion Study of NGM438 as Monotherapy and in Combination With Pembrolizumab in Advanced or Metastatic Solid Tumors

Study of NGM438 as Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumors

pembrolizumab
  • 0 views
  • 20 Oct, 2022
  • 5 locations
A Phase 1/1b Dose Escalation/Expansion Study of NGM831 as Monotherapy and in Combination With Pembrolizumab in Advanced or Metastatic Solid Tumors

Study of NGM831 as Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumors

pembrolizumab
  • 0 views
  • 28 Oct, 2022
  • 6 locations
Autologous CAR-T/TCR-T Cell Immunotherapy for Malignancies

This is a single arm, open-label, uni-center, phase I-II study to evaluate the safety and effectiveness of CAR-T/TCR-T cell immunotherapy in treating with different malignancies patients.

kidney function test
renal function
c-MET
blood test
hla-a
  • 231 views
  • 13 Feb, 2022
  • 1 location