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Found 446 clinical trials
A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Melanoma (Morpheus-Melanoma)

This study will evaluate the efficacy, safety, and pharmacokinetics of treatment combinations in cancer immunotherapy (CIT)-naive participants with resectable Stage III melanoma (Cohort and in participants with Stage IV melanoma (Cohort 2). The study is designed with the flexibility to open new treatment arms as new treatments become available, close …

ipilimumab
cancer
stage iii melanoma
combinations
melanoma skin
  • 0 views
  • 13 Jun, 2022
  • 18 locations
Education for Prevention of Melanoma in Hispanic Populations

This clinical trial is to develop an educational platform to educate and prevent melanoma in Hispanic populations. Melanoma is cancer arising in the skin. Educational platforms to increase the knowledge and practice of sun smart behaviors (sunscreen use, sun protective clothing use, self-skin examination) may help reduce risk of and …

Accepts healthy volunteers
cancer
  • 0 views
  • 14 Jun, 2022
  • 1 location
A Study to Assess Adjuvant Immunotherapy With Relatlimab and Nivolumab Versus Nivolumab Alone After Complete Resection of Stage III-IV Melanoma (RELATIVITY-098)

The purpose of this study is to assess relatlimab and nivolumab fixed-dose combination (FDC) versus nivolumab alone in participants with completely resected stage III-IV melanoma.

immunologic adjuvant
cancer
nivolumab
immunomodulators
  • 4 views
  • 19 Jun, 2022
  • 89 locations
A Study of SAR444245 Combined With Cemiplimab for the Treatment of Participants With Various Advanced Skin Cancers (Pegathor Skin 201)

Primary Objective: -To determine the antitumor activity of SAR444245 in combination with cemiplimab. Secondary Objectives: To determine the recommended phase 2 dose and to assess the safety profile of SAR444245 when combined with cemiplimab To assess other indicators of antitumor activity To assess the concentrations of SAR444245 when given in …

metastatic melanoma
measurable disease
metastasis
  • 0 views
  • 10 Jun, 2022
  • 33 locations
A Study of SAR444245 Combined With Cemiplimab for the Treatment of Participants With Various Advanced Skin Cancers (Pegathor Skin 201)

Primary Objective: -To determine the antitumor activity of SAR444245 in combination with cemiplimab. Secondary Objectives: To determine the recommended phase 2 dose and to assess the safety profile of SAR444245 when combined with cemiplimab To assess other indicators of antitumor activity To assess the concentrations of SAR444245 when given in …

metastatic melanoma
measurable disease
metastasis
  • 0 views
  • 19 Jun, 2022
  • 30 locations
Comparing SLNE With or Without Preoperative Hybrid SPECT/CT in Melanoma

Melanoma has become a growing interdisciplinary problem in public health worldwide. It characteristically disseminates in an orderly progression through lymphatic channels to the regional lymph node and then to more distant sites. Sentinel lymph node excision (SLNE) is probably the most important diagnostic and potentially therapeutic procedure for melanoma patients. …

ct scan
  • 1 views
  • 14 Feb, 2022
  • 10 locations
Substudy 02A: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents in Participants With Programmed Cell-death 1 (PD-1) Refractory Melanoma (MK-3475-02A/KEYMAKER-U02)

Substudy 02A is part of a larger research study that is testing experimental treatments for melanoma, a type of skin cancer. The larger study is the umbrella study. The goal of substudy

mk-3475
metastatic melanoma
advanced melanoma
cancer
immunologic adjuvant
  • 0 views
  • 25 Mar, 2022
  • 31 locations
Substudy 02C: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents or Pembrolizumab Alone in Participants With Stage III Melanoma Who Are Candidates for Neoadjuvant Therapy (MK-3475-02C/KEYMAKER-U02)

Substudy 02C is part of a larger research study that is testing experimental treatments for melanoma, a type of skin cancer. The larger study is the umbrella study. The goal of substudy

mk-3475
pembrolizumab
alopecia
cancer
stage iii melanoma
  • 0 views
  • 24 Mar, 2022
  • 23 locations
War on Melanoma™ Public Health & Education Campaign

This trial studies how well a health educational campaign works in increasing early detection of melanoma in Oregon. The health educational campaign may provide information to help people learn about the early signs of melanoma. Increased education in Oregon may decrease the number of people who die from melanoma and …

Accepts healthy volunteers
  • 52 views
  • 25 Mar, 2022
  • 1 location
Circulating Tumour DNA guidEd Therapy for Stage IIB/C mElanoma After surgiCal resecTION

The trial is looking for new and better ways to treat melanoma, an aggressive type of skin cancer. Having surgery to remove the melanoma will cure the majority of patients with early stage

neutrophil count
BRAF
cancer
human chorionic gonadotropin
NRAS
  • 0 views
  • 25 Nov, 2021
  • 1 location