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Found 151 clinical trials
PRF With Topical Antibiotics or Antiseptics in Chronical Wounds Version 1.4 (PRF-TAT)

Platelet rich fibrin (PRF) is a new therapy option for chronic wounds with yet unproven therapeutic efficacy. This randomised controlled trial aims to provide evidence of the efficacy of PRF as monotherapy as well as a growth promoting carrier matrix for antimicrobial compounds. The investigators therefore designed a four armed …

  • 18 Apr, 2022
  • 1 location
A Randomized, Placebo-Controlled, Double-blind, Dose-Ranging, Multicenter, Phase IIb Clinical Trial to Investigate the Efficacy and Safety of Allo-APZ2-CVU on Wound Healing of Therapy-Resistant Chronic Venous Ulcer (CVU)

The aim of this clinical trial is to investigate the efficacy (by monitoring the wound size reduction of CVUs) and safety (by monitoring adverse events [AEs]) of three dose groups of the investigational medicinal product (IMP) allo-APZ2-CVU, topically administered on target wounds of patients with CVU compared to placebo.

  • 19 Aug, 2022
  • 33 locations
Percutaneous Electrocoagulation Versus Sclerosing Foam for Patients With Incompetent Perforating Veins : A Multi-center Prospective Randomized Controlled Trial (PESIV)

This study aimed to compare the efficacy of punctured electrocoagulation and sclerotherapy in the treatment of incompetent perforator veins.

  • 14 Sep, 2022
  • 1 location
Iontophoresis of Treprostinil to Enhance Wound Healing in Diabetic Foot Skin Ulcers (InTREPiD)

Assess the effect of iontophoresis of treprostinil on wound closure over 12 weeks, in patients with DFU. In the present study the investigators aim at establishing the proof-of-concept of iontophoresis of treprostinil as a potential treatment of diabetic foot ulcers in humans. The main hypothesis is that in patients with …

type 2 diabetes mellitus
foot ulcer
skin ulcer
  • 23 May, 2022
  • 1 location
  • 21 Mar, 2022
  • 1 location
Safety, Tolerability and Efficacy of CYP-006TK in Adults With Diabetic Foot Ulcers

Design: A randomised, controlled, prospective trial. Participants will be patients with non-healing diabetic foot ulcers. The study will aim to recruit 15 participants per study group (30 participants in total). Participants will be randomly allocated to one of two treatment groups: Group 1: CYP-006TK Group 2: Standard care This will …

  • 06 Apr, 2022
  • 1 location
Baricitinib in the Treatment of Adults With Pyoderma Gangrenosum (PG)

An Open-Label, Proof-Of-Concept, Study of Baricitinib for the Treatment of Pyoderma Gangrenosum

  • 14 Sep, 2022
  • 1 location
Effectiveness of Autologous Platelet Rich Plasma in the Treatment of Chronic Non-Healing Wounds

This investigation plans to initiate the healing of chronic wounds by providing a concentrated platelet and growth factor therapy directly to the wound site by topical delivery. This therapy will be derived from autologous platelet rich plasma (PRP), an emerging surgical and wound care treatment. This investigation aims to demonstrate …

patient screening
platelet count
growth factor
Accepts healthy volunteers
wound care
  • 25 Mar, 2022
  • 1 location
Leg Ulcers Standards of Care Enhancement (LUCE)

group), following these inclusion/exclusion criteria: Inclusion criteria: Subjects suffering from venous and mixed skin ulcers; Presence of a lesion < 100 cm² of area

  • 26 Jul, 2022
  • 5 locations
Topical Sodium Nitrite in Sickle Cell Disease and Leg Ulcers

The investigators propose a Phase II study, prospective and placebo controlled, of a topical cream containing sodium nitrite compared to the current standard of care. Sodium nitrite is a local donor of nitric oxide, which is known to improve blood flow and decrease bacterial load in the ulcer bed. The …

leg ulcer
nitric oxide
  • 26 Apr, 2022
  • 2 locations