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Found 139 clinical trials
Efficacy of Rapamycin (Sirolimus) in the Treatment of BRBNS Hereditary or Sporadic Venous Malformation

A prospective, nonrandomized, open-label, single-arm clinical trial to study efficacy of rapamycin (sirolimus) in the treatment of Blue Rubber Bleb Nevus Syndrome, hereditary or sporadic venous

  • 1 views
  • 22 Jan, 2021
  • 1 location
Clinical Trial of Abluminus DES+ Sirolimus Eluting Stent Versus Everolimus-eluting DES

The objective of the study is to compare angiographic and clinical performance of Abluminus DES+ versus Everolimus-eluting DES in patients with diabetes mellitus.

everolimus
stenosis
unstable angina
sirolimus
coronary angioplasty
  • 43 views
  • 24 Jan, 2021
  • 9 locations
Efficacy and Safety of Rapamycin (Sirolimus) in the Treatment of Symptomatic Uterine Fibroids and Leiomyomatosis

A prospective non-randomized open label clinical trial to research the efficacy and safety of sirolimus in patients with symptomatic, recurrent uterine fibroids or/and various rare leiomyoma.

uterine myomectomy
uterine fibroid
MRI
leiomyomatosis
pelvic pressure
  • 59 views
  • 22 Jan, 2021
  • 1 location
Efficacy and Safety of Sirolimus in Vascular Anomalies That Are Refractory to Standard Care

The phosphatidylinositol 3-kinase (PI3Kinase)/Protein Kinase B (AKT)/mammalian target of rapamycin (mTor) pathway plays a role on the development and the venous/lymphatic vascular organisations. The investigators want to study the efficacy and the safety of Rapamycin, an mTor inhibitor.

  • 0 views
  • 21 Jan, 2021
  • 3 locations
PLX3397 Plus Sirolimus in Unresectable Sarcoma and Malignant Peripheral Nerve Sheath Tumors

The purpose of this study is to determine if treatment with PLX3397 and Sirolimus will be tolerated and result in shrinking of the cancer or stopping the cancer from growing. In the phase I

platelet count
cancer
KIT
solid tumour
mpnst
  • 0 views
  • 24 Jan, 2021
  • 3 locations
Prospective Evaluation of the Efficacy of Sirolimus (Rapamune ) in the Treatment of Severe Arteriovenous Malformations

The aim of the study is to evaluate the efficacy and safety of sirolimus (oral form), to decrease the volume and symptoms due to superficial arteriovenous malformations (AVM). Sirolimus

immunosuppressant
cancer
sirolimus
  • 6 views
  • 24 Jan, 2021
  • 13 locations
Sirolimus and Cyclophosphamide in Metastatic or Unresectable Myxoid Liposarcoma and Chondrosarcoma

consortium (www.eurosarc.eu) decided to treat these patients in a standardised way according to a common protocol with the combination of sirolimus and cyclophosphamide

  • 43 views
  • 24 Jan, 2021
  • 10 locations
A Phase I/II GVHD Prevention Trial Combining Pacritinib With Sirolimus-Based Immune Suppression

/II, study of Pacritinib with Sirolimus and Tacrolimus (PAC/SIR/TAC) for the prevention of acute GVHD after matched related and unrelated allogeneic hematopoietic cell transplantation (alloHCT).

acute leukemia
chronic myeloid leukemia
myeloproliferative disorder
karnofsky performance status
myeloid leukemia
  • 9 views
  • 26 Jan, 2021
  • 1 location
FANTOM ENCORE Sirolimus-eluting Bioresorbable Scaffold for Treatment of De-novo CAD: the ENCORE-I Study

Prospective, multicentre, non-randomized, investigator-initiated study aiming to assess the safety and efficacy of the Fantom Encore sirolimus-eluting bioresorbable scaffold (BRS).

ischemia
  • 0 views
  • 25 Jan, 2021
  • 3 locations
Efficacy of Rapamycin (Sirolimus) in the Treatment of Peutz-Jeghers Syndrome

A prospective non-randomized open label single arm clinical trial to examine the efficacy and safety of sirolimus in patients with Peutz-Jeghers Syndrome.

  • 0 views
  • 22 Jan, 2021
  • 1 location