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Found 147 clinical trials
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A Randomized Trial of Sirolimus (Rapamune) for Relapse Prevention in Patients with Severe Aplastic Anemia Responsive to Immunosuppressive Therapy

from making these cells. The treatment cyclosporine leads to better blood counts. But when this treatment is stopped, the disease may return in 1 in 3 people. The drug sirolimus may help by suppressing

aplastic anemia
myelodysplastic syndrome (mds)
myelodysplastic syndromes
anemia
anemia studies
  • 61 views
  • 22 Dec, 2020
  • 1 location
featured
Research Study of ATG and Rituximab in Renal Transplantation (RESTARRT)

Research Study of ATG and Rituximab in Renal Transplantation (RESTARRT)

  • 1087 views
  • 23 Nov, 2020
  • 5 locations
featured
Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease

Background: Peripheral blood stem cell transplantation procedures are used for people with sickle cell disease. Researchers want to improve the success and reduce the complications for these procedures. This might allow more people to have a transplant. Objective: To see if a new transplant regime is effective, safe and well …

cell transplantation
sickle cell disease
stroke
red blood cell disorder
  • 57 views
  • 22 Dec, 2020
  • 1 location
LUMINA Phase III Study Assessing the Efficacy and Safety of Intravitreal Injections of 440 ug DE-109 Sirolimus for the Treatment of Active Non-Infectious Uveitis of the Posterior Segment of the Eye

This is a Phase III study to assess the efficacy and safety of DE-109 440 g every 2 months in subjects with active, non-infectious uveitis of the posterior segment of the eye (NIU-PS). There is a 6-month, single-arm, open-label period after completion of the 6-month doublemasked, controlled period allows the …

  • 165 views
  • 07 Aug, 2021
  • 92 locations
Sirolimus for Retinal Astrocytic Hamartoma

A single patient study using intravitreal Sirolimus to treat a patient with multiple retinal astrocytic hamartomas (RAH) of both eyes.

  • 0 views
  • 01 Feb, 2021
  • 1 location
Study of Sirolimus in Idiopathic Retroperitoneal Fibrosis

reducing the toxic and side effects of long-term corticosteroid. Sirolimus plays dual roles in inhibiting lymphocyte activation and fibroblast proliferation. It is inferred from its mechanism that

  • 0 views
  • 23 Mar, 2021
  • 1 location
Sirolimus DEB in Coronary Bifurcation Lesions

The purpose of this study is to evaluate the efficacy and safety of sirolimus drug-eluting coronary balloon catheter in treatment of coronary bifurcation lesions. This is a prospective

  • 0 views
  • 29 May, 2021
  • 1 location
The Effect of Sirolimus on the Pharmacokinetics of Tacrolimus

The purpose of this study is to understand whether the pharmacokinetics of tacrolimus is influenced by the concurrent use of sirolimus.

sirolimus
tacrolimus
mycophenolate
  • 3 views
  • 07 Nov, 2020
  • 1 location
Sirolimus and Cyclosporine for Treatment-Resistant Aplastic Anemia

often the cause remains unknown. The purpose of this study is to determine the safety and efficacy of combining two drugs, sirolimus and cyclosporine, for treating individuals with aplastic

aplastic anemia
platelet count
neutrophil count
sirolimus
cyclosporine
  • 100 views
  • 07 Nov, 2020
  • 1 location
TOPical Sirolimus in linGUal Microcystic Lymphatic Malformation -TOPGUN

lymphatic malformations, whatever the location, treatment with oral sirolimus, an mTOR (mammalian Target of Rapamycin) inhibitor, is often used. Topical sirolimus is a known effective treatment for

  • 0 views
  • 11 Mar, 2021
  • 3 locations