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Found 137 clinical trials
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A Randomized Trial of Sirolimus (Rapamune) for Relapse Prevention in Patients with Severe Aplastic Anemia Responsive to Immunosuppressive Therapy

from making these cells. The treatment cyclosporine leads to better blood counts. But when this treatment is stopped, the disease may return in 1 in 3 people. The drug sirolimus may help by suppressing

anemia
myelodysplastic syndromes
anemia studies
myelodysplastic syndrome (mds)
aplastic anemia
  • 61 views
  • 22 Dec, 2020
  • 1 location
featured
Research Study of ATG and Rituximab in Renal Transplantation (RESTARRT)

Research Study of ATG and Rituximab in Renal Transplantation (RESTARRT)

  • 1078 views
  • 23 Nov, 2020
  • 5 locations
featured
Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease

Background: Peripheral blood stem cell transplantation procedures are used for people with sickle cell disease. Researchers want to improve the success and reduce the complications for these procedures. This might allow more people to have a transplant. Objective: To see if a new transplant regime is effective, safe and well …

sickle cell disease
red blood cell disorder
stroke
cell transplantation
  • 57 views
  • 22 Dec, 2020
  • 1 location
LUMINA Phase III Study Assessing the Efficacy and Safety of Intravitreal Injections of 440 ug DE-109 Sirolimus for the Treatment of Active Non-Infectious Uveitis of the Posterior Segment of the Eye

This is a Phase III study to assess the efficacy and safety of DE-109 440 g every 2 months in subjects with active, non-infectious uveitis of the posterior segment of the eye (NIU-PS). There is a 6-month, single-arm, open-label period after completion of the 6-month doublemasked, controlled period allows the …

  • 126 views
  • 31 Dec, 2020
  • 80 locations
Study of Sirolimus in Idiopathic Retroperitoneal Fibrosis

reducing the toxic and side effects of long-term corticosteroid. Sirolimus plays dual roles in inhibiting lymphocyte activation and fibroblast proliferation. It is inferred from its mechanism that

  • 0 views
  • 24 Jan, 2021
  • 1 location
Sirolimus and Cyclosporine for Treatment-Resistant Aplastic Anemia

often the cause remains unknown. The purpose of this study is to determine the safety and efficacy of combining two drugs, sirolimus and cyclosporine, for treating individuals with aplastic

severe aplastic anemia
cyclosporine
sirolimus
aplastic anemia
reticulocyte count
  • 100 views
  • 07 Nov, 2020
  • 1 location
The Effect of Sirolimus on the Pharmacokinetics of Tacrolimus

The purpose of this study is to understand whether the pharmacokinetics of tacrolimus is influenced by the concurrent use of sirolimus.

sirolimus
mycophenolate
tacrolimus
  • 3 views
  • 07 Nov, 2020
  • 1 location
TOPical Sirolimus in linGUal Microcystic Lymphatic Malformation -TOPGUN

lymphatic malformations, whatever the location, treatment with oral sirolimus, an mTOR (mammalian Target of Rapamycin) inhibitor, is often used. Topical sirolimus is a known effective treatment for

  • 0 views
  • 30 Sep, 2020
  • 2 locations
Impact of Conversion From Tacrolimus to Sirolimus in African American Renal Transplant Recipients

) from a tacrolimus-based regimen to a sirolimus-based maintenance immunosuppression regimen. The investigators hypothesize that the conversion from tacrolimus to sirolimus in African

  • 20 views
  • 08 Nov, 2020
  • 1 location
Sirolimus-Based Immunosuppression Therapy in OLT for Patients With HCC Exceeding Milan Criteria

The purpose of this study is to evaluate the influence of sirolimus on outcome after OLT for HCC exceeding Milan criteria.

vascular invasion
  • 1 views
  • 07 Nov, 2020
  • 1 location