Found 137 clinical trials
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Phase 3 trial
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Accepting pediatric ages
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Accepting Seniors
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Hematology
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Currently Recruiting
A Randomized Trial of Sirolimus (Rapamune) for Relapse Prevention in Patients with Severe Aplastic Anemia Responsive to Immunosuppressive Therapy
from making these cells. The treatment cyclosporine leads to better blood counts. But when this treatment is stopped, the disease may return in 1 in 3 people. The drug sirolimus may help by suppressing
- 61 views
- 22 Dec, 2020
- 1 location
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Unknown Phase
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Accepting adults
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Currently Recruiting
Research Study of ATG and Rituximab in Renal Transplantation (RESTARRT)
Research Study of ATG and Rituximab in Renal Transplantation (RESTARRT)
- 1078 views
- 23 Nov, 2020
- 5 locations
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Unknown Phase
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Accepting pediatric ages
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Accepting Seniors
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Currently Recruiting
Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease
Background: Peripheral blood stem cell transplantation procedures are used for people with sickle cell disease. Researchers want to improve the success and reduce the complications for these procedures. This might allow more people to have a transplant. Objective: To see if a new transplant regime is effective, safe and well …
- 57 views
- 22 Dec, 2020
- 1 location
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Multi-country trial
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Phase 3 trial
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Accepting Seniors
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Accepting adults
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100s of participants
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An interventional trial
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For all genders
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Currently Recruiting
LUMINA Phase III Study Assessing the Efficacy and Safety of Intravitreal Injections of 440 ug DE-109 Sirolimus for the Treatment of Active Non-Infectious Uveitis of the Posterior Segment of the Eye
This is a Phase III study to assess the efficacy and safety of DE-109 440 g every 2 months in subjects with active, non-infectious uveitis of the posterior segment of the eye (NIU-PS). There is a 6-month, single-arm, open-label period after completion of the 6-month doublemasked, controlled period allows the …
- 126 views
- 31 Dec, 2020
- 80 locations
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Phase 2 trial
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Accepting Seniors
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Accepting adults
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10s of participants
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An interventional trial
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For all genders
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Currently Recruiting
Study of Sirolimus in Idiopathic Retroperitoneal Fibrosis
reducing the toxic and side effects of long-term corticosteroid. Sirolimus plays dual roles in inhibiting lymphocyte activation and fibroblast proliferation. It is inferred from its mechanism that
- 0 views
- 24 Jan, 2021
- 1 location
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Phase 1 trial
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Accepting Seniors
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Accepting adults
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10s of participants
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An interventional trial
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For all genders
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Hematology
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Currently Recruiting
Sirolimus and Cyclosporine for Treatment-Resistant Aplastic Anemia
often the cause remains unknown. The purpose of this study is to determine the safety and efficacy of combining two drugs, sirolimus and cyclosporine, for treating individuals with aplastic
- 100 views
- 07 Nov, 2020
- 1 location
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Phase 4 trial
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Accepting pediatric ages
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10s of participants
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An interventional trial
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For all genders
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Nephrology
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Currently Recruiting
The Effect of Sirolimus on the Pharmacokinetics of Tacrolimus
The purpose of this study is to understand whether the pharmacokinetics of tacrolimus is influenced by the concurrent use of sirolimus.
- 3 views
- 07 Nov, 2020
- 1 location
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Phase 2 trial
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Accepting pediatric ages
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Accepting Seniors
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10s of participants
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An interventional trial
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For all genders
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Currently Recruiting
TOPical Sirolimus in linGUal Microcystic Lymphatic Malformation -TOPGUN
lymphatic malformations, whatever the location, treatment with oral sirolimus, an mTOR (mammalian Target of Rapamycin) inhibitor, is often used. Topical sirolimus is a known effective treatment for
- 0 views
- 30 Sep, 2020
- 2 locations
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Phase 4 trial
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Accepting Seniors
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Accepting adults
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10s of participants
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An interventional trial
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For all genders
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Currently Recruiting
Impact of Conversion From Tacrolimus to Sirolimus in African American Renal Transplant Recipients
) from a tacrolimus-based regimen to a sirolimus-based maintenance immunosuppression regimen. The investigators hypothesize that the conversion from tacrolimus to sirolimus in African
- 20 views
- 08 Nov, 2020
- 1 location
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Phase 3 trial
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Accepting Seniors
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Accepting adults
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100s of participants
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An interventional trial
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For all genders
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Currently Recruiting
Sirolimus-Based Immunosuppression Therapy in OLT for Patients With HCC Exceeding Milan Criteria
The purpose of this study is to evaluate the influence of sirolimus on outcome after OLT for HCC exceeding Milan criteria.
- 1 views
- 07 Nov, 2020
- 1 location