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Found 31 clinical trials
Myocardial Protection Effect of Simvastatin Undergoing Cardiac Surgery

artery bypass graft. The investigators recent found simvastatin reduced myocardial injury during noncoronary artery cardiac surgery in single medical center. The investigators further investigate that

hmg-coa reductase inhibitors
cardiopulmonary bypass
bypass graft
valvular disease
coronary artery disease
  • 25 views
  • 27 Jan, 2021
  • 1 location
Pharmacokinetics of Simvastatin Post Laparoscopic Sleeve Gastrectomy (LSG)

This study aims to investigate the change in systemic exposure of simvastatin post LSG.

  • 0 views
  • 24 Apr, 2022
  • 1 location
Simvastatin Plus Dual Anti-HER2 Therapy for Metastatic Breast Cancer (SIMPHONY)

This study recruits patients with metastatic breast cancer who have progressed on their current regimen of dual anti-HER2 therapy. This study evaluates whether or not the addition of simvastatin

platelet count
ejection fraction
breast cancer
HER2
hormone therapy
  • 10 views
  • 18 Apr, 2022
  • 2 locations
Neurotoxicity Prophylaxis With Intrathecal Dexamethasone and Simvastatin Post Axi-Cel

Open-label, single-arm, single center pilot study to assess safety and feasibility of administering dexamethasone intrathecally and simvastatin orally during axicabtagene ciloleucel (axi-cel

diffuse large b-cell lymphoma
lymphoma
remission
large b-cell lymphoma
high dose chemotherapy
  • 0 views
  • 02 Sep, 2021
  • 1 location
Combined Simvastatin and Albumin Paclitaxel in Treating ES-SCLC Patients Relapsed From 1st Chemotherapy

This Phase II study was designed to evaluate the safety and efficacy of albumin paclitaxel in combination with simvastatin compared with treatment with albumin paclitaxel alone in ES-SCLC

progressive disease
EGFR
cancer chemotherapy
measurable disease
  • 0 views
  • 08 Aug, 2021
  • 2 locations
Effect of Simvastatin on Sepsis and Febrile Neutropenia in Patients With Acute Lymphoblastic Leukemia

In general, the percentage of complete remissions is 85 - 90 % for acute lymphoid leukemia (ALL). In developing countries, percentages are lower secondary to higher sepsis-related mortality. Although the effect of statins on inflammatory response associated with sepsis has been demonstrated, including an effect on bacterial proliferation in patients …

inflammatory response
cancer
  • 0 views
  • 24 Mar, 2022
  • 1 location
Simvastatin add-on Treatment to Standard Antidepressant Therapy in Patients With Comorbid Obesity and Major Depression (SIMCODE)

patients with MDD and comorbid obesity. Therefore, we hypothesize that Simvastatin add-on to standard antidepressant Escitalopram will improve depression to a greater extent than add-on placebo in patients

ketamine
schizophrenia
psychotropic drugs
bipolar disorder
bariatric surgery
  • 0 views
  • 01 Mar, 2022
Multi-Center Study of the Effects of Simvastatin on Hepatic Decompensation and Death in Subjects Presenting With High-Risk Compensated Cirrhosis (SACRED)

This phase III, randomized, double-blind, placebo-controlled, multi-center study seeks to test whether simvastatin, a statin usually used to lower cholesterol to prevent heart problems and

platelet count
ascites
hepatitis
hypertension
cirrhosis
  • 0 views
  • 07 Jul, 2022
  • 11 locations
The Effect of 28-day Simvastatin Administration on Emotional Processing, Reward Learning, Working Memory, and Salivary Cortisol in Healthy Volunteers At-risk for Depression (OxSTEP)

Simvastatin is being employed because it is a 'statin'. As a drug class, statins have broad anti-inflammatory properties. Low-level inflammation is thought to be a potentially important mediator

Accepts healthy volunteers
depressed mood
hmg-coa reductase inhibitors
body mass index
depression
  • 4 views
  • 20 Sep, 2022
  • 1 location
Statin Therapy to Reduce Progression in Women With Platinum Sensitive Ovarian Cancer

This is a single arm pilot trial to evaluate the feasibility of using a simvastatin intervention, and to evaluate its effects on cancer progression, among 20 patients with platinum-sensitive

  • 0 views
  • 12 May, 2022
  • 1 location