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Found 28 clinical trials
Featured trial
A 24-week, double-blind, randomized, parallel-group study evaluating the efficacy and safety of oral nintedanib coadministered with oral sildenafil, compared to treatment with nintedanib alone, in patients with idiopathic pulmonary fibrosis (IPF) and advanced lung function impairment

A 24-week, double-blind, randomized, parallel-group study evaluating the efficacy and safety of oral nintedanib coadministered with oral sildenafil, compared to treatment with nintedanib alone, in

  • 1316 views
  • 23 Nov, 2020
  • 1 location
Sildenafil Citrate and Intrapartum Fetal Distress

Induction of labour (IOL) is done for 20% of pregnancies for various maternal and fetal indications and nearly 20% of labour inductions end up in caesarean section. The most common causes are failed induction and intrapartum fetal distress. In spite of significant advances in methods of IOL and intrapartum fetal …

  • 0 views
  • 26 Jan, 2021
  • 1 location
L-arginine Versus Sildenafil in Children With Beta Thalassemia Associated With Pulmonary Hypertension

This study compares L-arginine Versus Sildenafil as treatment for pulmonary hypertension in Children with Beta Thalassemia

sildenafil
hypertension
arginine
beta thalassemia
  • 6 views
  • 22 Jan, 2021
  • 1 location
The Impact of Sildenafil on the Pulmonary Circulation in Healthy Trained and Untrained Humans

determined experimentally. If sildenafil administration improves DLCO, Vc, and Dm, this would provide evidence that the NO mediated vasodilatory pathway plays a role in the regulation of vascular tone

  • 0 views
  • 24 Sep, 2021
  • 1 location
Sildenafil To Prevent Clot

proposal will investigate if hemolysis associated increased platelet function can be reduced by a potentiation of nitric oxide signaling by an oral phosphodiesterase-5 inhibitor, sildenafil. Elucidating

platelet aggregation
stroke
heart failure
clot
thrombosis
  • 0 views
  • 08 Nov, 2021
  • 1 location
Sildenafil Exercise: Role of PDE5 Inhibition

administration of the phosphodiesterase type 5 (PDE5) inhibitor, sildenafil.

forced expiratory volume
antibiotics
pilocarpine
spirometry
oximetry
  • 0 views
  • 08 Sep, 2021
  • 2 locations
Safety of Sildenafil in Premature Infants

Describe the safety of sildenafil in premature infants at risk of bronchopulmonary dysplasia and determine preliminary effectiveness and pharmacokinetics (PK) of sildenafil. Funding Source - FDA

intermittent positive pressure ventilation
prematurity
premature birth
  • 34 views
  • 14 Nov, 2021
  • 21 locations
Sildenafil to Repair Brain Injury Secondary to Birth Asphyxia

The investigators will determine the maximum tolerable dose of sildenafil and establish the pharmacokinetic and pharmacodynamic profile of sildenafil in human asphyxiated neonates treated with

encephalopathy
perinatal brain injury
hypothermia
electroencephalogram
base deficit
  • 0 views
  • 24 Jan, 2021
  • 2 locations
Safety of Sildenafil in Premature Infants With Severe Bronchopulmonary Dysplasia

This is a multicenter, randomized, placebo-controlled, sequential dose-escalating, double-masked, safety study of sildenafil in premature infants (inpatient in Neonatal Intensive Care Units

  • 0 views
  • 18 Jun, 2021
  • 1 location
Sildenafil for Early Pulmonary Vascular Disease in Scleroderma

This is a Phase II randomized, double-blind, placebo-controlled trial of sildenafil in men and women with Scleroderma with mildly elevated pulmonary pressures (SSc-MEP) to determine whether

vascular disease
scleroderma
hypertension
sildenafil
rheumatism
  • 0 views
  • 04 Oct, 2021
  • 2 locations