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Found 30 clinical trials
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A 24-week, double-blind, randomized, parallel-group study evaluating the efficacy and safety of oral nintedanib coadministered with oral sildenafil, compared to treatment with nintedanib alone, in patients with idiopathic pulmonary fibrosis (IPF) and advanced lung function impairment

A 24-week, double-blind, randomized, parallel-group study evaluating the efficacy and safety of oral nintedanib coadministered with oral sildenafil, compared to treatment with nintedanib alone, in

  • 1324 views
  • 23 Nov, 2020
  • 1 location
Sildenafil Citrate and Intrapartum Fetal Distress

Induction of labour (IOL) is done for 20% of pregnancies for various maternal and fetal indications and nearly 20% of labour inductions end up in caesarean section. The most common causes are failed induction and intrapartum fetal distress. In spite of significant advances in methods of IOL and intrapartum fetal …

  • 0 views
  • 30 May, 2022
  • 1 location
L-arginine Versus Sildenafil in Children With Beta Thalassemia Associated With Pulmonary Hypertension

This study compares L-arginine Versus Sildenafil as treatment for pulmonary hypertension in Children with Beta Thalassemia

sildenafil
arginine
hypertension
beta thalassemia
  • 27 views
  • 23 Feb, 2022
  • 1 location
The Impact of Sildenafil on the Pulmonary Circulation in Healthy Trained and Untrained Humans

determined experimentally. If sildenafil administration improves DLCO, Vc, and Dm, this would provide evidence that the NO mediated vasodilatory pathway plays a role in the regulation of vascular tone

Accepts healthy volunteers
  • 0 views
  • 22 Apr, 2022
  • 1 location
A Trial for Prevention of Recurrent Ischemic Priapism in Men With Sickle Cell Disease: A Pilot Study (PIN)

To conduct a randomized controlled internal pilot feasibility trial for the prevention of recurrent ischemic priapism referred to as the Priapism in Nigeria (PIN) trial. The study team will enroll a minimum of 30 participants and a maximum of 200 participants. Study investigators hypothesize that hydroxyurea therapy combined with tadalafil …

  • 0 views
  • 29 Apr, 2022
  • 1 location
Sildenafil To Prevent Clot (SToPClot)

proposal will investigate if hemolysis associated increased platelet function can be reduced by a potentiation of nitric oxide signaling by an oral phosphodiesterase-5 inhibitor, sildenafil. Elucidating

stroke
platelet aggregation
thrombosis
clot
heart failure
  • 0 views
  • 03 Feb, 2022
  • 1 location
Safety of Sildenafil in Premature Infants (SIL02)

Describe the safety of sildenafil in premature infants at risk of bronchopulmonary dysplasia and determine preliminary effectiveness and pharmacokinetics (PK) of sildenafil. Funding Source - FDA

prematurity
intermittent positive pressure ventilation
premature birth
  • 34 views
  • 01 Mar, 2022
  • 11 locations
Sildenafil for Treatment of Choroidal Ischemia

The hypothesis of this study is to determine if there is a benefit afforded by the use of systemic Sildenafil to patients with choroidal and retinal degenerations and dystrophies, such as

retinopathy
drusen
choroidal degenerations
age-related macular degeneration
choroidal ischemia
  • 22 views
  • 10 May, 2022
  • 1 location
Sildenafil Exercise: Role of PDE5 Inhibition

administration of the phosphodiesterase type 5 (PDE5) inhibitor, sildenafil.

fibrosis
spirometry
diabetes
pilocarpine
oximetry
  • 0 views
  • 08 Sep, 2021
  • 2 locations
Sildenafil for Early Pulmonary Vascular Disease in Scleroderma

This is a Phase II randomized, double-blind, placebo-controlled trial of sildenafil in men and women with Scleroderma with mildly elevated pulmonary pressures (SSc-MEP) to determine whether

rheumatism
sildenafil
hypertension
scleroderma
interstitial lung disease
  • 0 views
  • 04 Oct, 2021
  • 2 locations