Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 227 clinical trials
Topical Sodium Nitrite in Sickle Cell Disease and Leg Ulcers

patients with sickle cell disease and chronic leg ulcers and to determine its effectiveness in accelerating the healing process and decreasing the pain associated with ulceration. Potential benefit

leg ulcer
nitric oxide
nitrite
thalassemia
  • 33 views
  • 26 Apr, 2022
  • 2 locations
Losartan for Diffuse Myocardial Fibrosis in Sickle Cell Disease

This study is a pilot, phase II, open-label study of the angiotensin II receptor blocker, losartan, in patients with Sickle Cell Disease (SCD) 6 years or older for 12 months. The investigators

Accepts healthy volunteers
  • 0 views
  • 26 Jan, 2022
  • 1 location
Study of PF-07209326 in Participants with Sickle Cell Disease

This Phase 1 first-in-human single ascending dose and multiple dose study will be a randomized, double-blind, investigation of the safety, tolerability, and pharmacokinetics of PF-07209326.

Accepts healthy volunteers
body mass index
  • 29 views
  • 23 Apr, 2022
  • 3 locations
Stem Cell Transplant in Patients With Severe Sickle Cell Disease

This is a prospective pilot study of matched-related donor allogeneic stem cell transplantation in adults with severe sickle cell disease using a matched-sibling PBSC graft with a non

blood transfusion
sirolimus
acute chest syndrome
priapism
sickle cell trait
  • 31 views
  • 01 May, 2022
  • 1 location
Stem Cell Gene Therapy for Sickle Cell Disease

This Phase I clinical trial will assess the safety and initial evidence for efficacy of an autologous transplant of lentiviral vector modified peripheral blood for adults with severe sickle cell

gene therapy
  • 0 views
  • 20 Apr, 2022
  • 1 location
Reduced Intensity Transplantation for Severe Sickle Cell Disease

children and young adults with Sickle Cell Disease (SCD). Patients less than or equal to 25 years old with SCD who would likely benefit from allogeneic hematopoietic cell transplantation (HCT) will be

sirolimus
acute chest syndrome
priapism
sickle cell trait
stroke
  • 0 views
  • 29 May, 2022
  • 1 location
Gene Transfer for Patients With Sickle Cell Disease

The purpose of this Phase 1/2 study is to determine the feasibility and safety of stem cell collection and gamma-globin gene transfer, and success of gene correction in subjects with sickle cell

blood transfusion
exchange transfusion
plerixafor
acute chest syndrome
apheresis
  • 374 views
  • 26 Jan, 2022
  • 4 locations
Interest of Famotidine in Children With Sickle Cell Disease (FAMODREP)

effective in reducing endothelial expression of P-selectin in children with sickle cell disease (SCD). This pilot study will constitute the essential prerequisite for a randomized clinical trial

acute chest syndrome
priapism
glutamine
hydroxyurea
stroke
  • 0 views
  • 15 Mar, 2022
TMLI and Alemtuzumab for Treatment of Sickle Cell Disease

This phase I trial tests the safety and effectiveness of total marrow and lymphoid irradiation (TMLI) and alemtuzumab as a conditioning regimen in patients with sickle cell disease. Conditioning

osteonecrosis
sirolimus
Accepts healthy volunteers
acute chest syndrome
priapism
  • 0 views
  • 16 Jun, 2022
  • 1 location
Early Life Exposures Among Children With Sickle Cell Disease

, among children with sickle cell disease, and behavioral interventions aimed to reshape psychological resilience and lifestyle factors towards positive health outcomes.

  • 0 views
  • 27 Jun, 2022
  • 1 location