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Found 228 clinical trials
L-Glutamine Therapy for Sickle Cell Anemia

This is a study to determine the efficacy of L-glutamine as therapy for sickle cell anemia and sickle O-thalassemia.

thalassemia
anemia
glutamine
  • 86 views
  • 07 Nov, 2020
  • 1 location
Sleep and Pain in Sickle Cell Disease

This is a study testing the effects of behavioral sleep interventions on pain and brain function in sickle cell disease.

hemoglobinopathy
sleep problem
chronic pain
thalassemia
insomnia
  • 36 views
  • 15 Jun, 2022
  • 1 location
Defibrotide in Sickle Cell Disease-Related Acute Chest Syndrome

This study evaluates the safety of defibrotide in subjects with sickle cell disease (SCD)-associated acute chest syndrome (ACS).

oximetry
hemoglobin s
chest syndrome
chest x-ray
thalassemia
  • 1 views
  • 26 Feb, 2022
  • 1 location
iPeer2Peer Program for Youth With Sickle Cell Disease

The iPeer2Peer Sickle Cell Disease (SCD) study matches youth (12-18 years of age) with SCD to a mentor (trained young adult) who has learned to manage their SCD well, transitioned to adult care

adult care
  • 0 views
  • 27 May, 2022
  • 4 locations
Gene Transfer for Patients With Sickle Cell Disease

The purpose of this Phase 1/2 study is to determine the feasibility and safety of stem cell collection and gamma-globin gene transfer, and success of gene correction in subjects with sickle cell

analgesia
hydroxyurea
exchange transfusion
chest syndrome
apheresis
  • 374 views
  • 26 Jan, 2022
  • 4 locations
Interest of Famotidine in Children With Sickle Cell Disease (FAMODREP)

effective in reducing endothelial expression of P-selectin in children with sickle cell disease (SCD). This pilot study will constitute the essential prerequisite for a randomized clinical trial

splenic sequestration
stroke
voxelotor
hydroxyurea
chest syndrome
  • 0 views
  • 15 Mar, 2022
Reduced Intensity Transplantation for Severe Sickle Cell Disease

children and young adults with Sickle Cell Disease (SCD). Patients less than or equal to 25 years old with SCD who would likely benefit from allogeneic hematopoietic cell transplantation (HCT) will be

cyclophosphamide
hydroxyurea
cerebral blood flow
chest syndrome
alemtuzumab
  • 0 views
  • 29 May, 2022
  • 1 location
Topical Sodium Nitrite in Sickle Cell Disease and Leg Ulcers

patients with sickle cell disease and chronic leg ulcers and to determine its effectiveness in accelerating the healing process and decreasing the pain associated with ulceration. Potential benefit

nitric oxide
thalassemia
leg ulcer
nitrite
  • 33 views
  • 26 Apr, 2022
  • 2 locations
Hematopoietic Stem Cell Transplant for Sickle Cell Disease

This is a phase I/II study of patients with sickle cell disease. It aims to find out if people with sickle cell disease can be cured by changing their immune system before they have blood stem

hemoglobin s
chest syndrome
thalassemia
tacrolimus
anti-thymocyte globulin
  • 84 views
  • 14 Jun, 2022
  • 1 location
TMLI and Alemtuzumab for Treatment of Sickle Cell Disease

This phase I trial tests the safety and effectiveness of total marrow and lymphoid irradiation (TMLI) and alemtuzumab as a conditioning regimen in patients with sickle cell disease. Conditioning

hydroxyurea
osteonecrosis
sirolimus
asthma
chest syndrome
  • 0 views
  • 16 Jun, 2022
  • 1 location