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Found 228 clinical trials
Study to Evaluate the Effect of GBT440 on TCD in Pediatrics With Sickle Cell Disease (HOPE Kids 2)

This study is a Phase 3, randomized, double-blind, placebo-controlled study of voxelotor in pediatric participants, aged 2 to < 15 years old, with Sickle Cell Disease. The primary objective

gbt440
anemia
voxelotor
transcranial doppler ultrasonography
cerebral blood flow
  • 224 views
  • 02 Mar, 2022
  • 25 locations
A Study Evaluating the Safety, Pharmacokinetics, Pharmacodynamics and Efficacy of Crovalimab for the Management of Acute Uncomplicated Vaso-Occlusive Episodes (VOE) in Participants With Sickle Cell Disease (SCD). (CROSSWALK-a)

The purpose of this study is to evaluate crovalimab for the treatment of a sickle cell pain crisis (also known as a VOE) that requires hospitalisation in adult and adolescent participants with SCD. The primary objective of this study is safety and will additionally evaluate pharmacokinetics (how crovalimab is processed …

thalassemia
opioid
  • 0 views
  • 25 May, 2022
  • 10 locations
A Study of a Single Dose of Inclacumab to Reduce Re-admission in Participants With Sickle Cell Disease and Recurrent Vaso-occlusive Crises

cell disease (SCD). Participants will be randomized to receive either inclacumab or placebo.

glutamine
chest syndrome
acute chest syndrome
narcotics
vaso-occlusive crisis
  • 0 views
  • 16 Jun, 2022
  • 14 locations
Dihydroartemisinin-Piperaquine or Sulphadoxine-Pyrimethamine for the Chemoprevention of Malaria in Sickle Cell Anaemia

Sickle Cell Anaemia (SCA) is an inherited disease that makes the body produce red blood cells with abnormal sickle-shaped cells. The sickle-shaped cells are rigid, not flexible and break up

  • 0 views
  • 18 Aug, 2021
  • 3 locations
Outcomes Mandate National Integration With Cannabis as Medicine (OMNI-Can)

This will be a multistate, multicenter clinical study to determine the efficacy and safety of medical cannabis for a wide variety of chronic medical conditions.

disease or disorder
medical marijuana
brimonidine tartrate ophthalmic solution
covid-19
Accepts healthy volunteers
  • 15070 views
  • 13 Jun, 2022
  • 16 locations
PROphylaxis for Venous ThromboEmbolism in Severe Traumatic Brain Injury (PROTEST) (PROTEST)

This is a pilot study, phase III, multi-centre, double blind, randomized controlled trial of patients with traumatic brain injury (TBI).

subarachnoid hemorrhage
severe traumatic brain injury
traumatic brain injury
  • 104 views
  • 16 Feb, 2022
  • 10 locations
A Trial to Assess the Effect of Transfusion Strategies on Fatigability Levels After Hospital Discharge (EToF)

This study is a randomized controlled trial in which hospitalized patients with anemia are randomized to receive transfusion at: a) Hb<9g/dL (liberal transfusion strategy), or b) Hb<7g/dL (restrictive transfusion strategy). We are measuring self-reported fatigability, fatigue, and activity levels at randomization and 7 days post hospital discharge in both trial …

anemia
red blood cell transfusion
  • 0 views
  • 05 Jun, 2022
  • 1 location
Sleep Apnea in Sickle Cell Disease (DREPAPNEE)

pathophysiological mechanisms are scarce. OSA is one of the most common conditions responsible for hemoglobin desaturation. The nocturnal hemoglobin desaturation occurring in some sickle cell disease (SCD) patients

hemoglobin s
sickle cell trait
vaso-occlusive crisis
blood transfusion
sickle hemoglobin
  • 10 views
  • 01 Feb, 2022
  • 3 locations
Imatinib for Pain in Sickle Cell Anemia (IMPACT)

phosphorylation and the abundances of RBC-derived microparticles in their blood. In addition, the patients will be monitored for symptoms of sickle cell disease (SCD). The investigators expect band 3 tyrosine

chest syndrome
acute chest syndrome
opiates
thalassemia
absolute neutrophil count
  • 0 views
  • 26 Jan, 2022
  • 2 locations
Telemedicine for Children With Sickle Cell Disease

The purpose of this study is to learn more about how the use of two different types of telemedicine (distance medical care) can address barriers to receiving comprehensive sickle cell care, and whether care can be improved. Aim 1: Adapt two telemedicine models (i.e., hub-and-spoke; direct-to-consumer) for use with children …

  • 0 views
  • 06 May, 2022
  • 1 location