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Found 211 clinical trials
Vitamin D Status in Children With Sickle Cell Disease Living in Lyon, France (EVADDREP)

Vitamin D deficiency may be under-diagnosed in sickle cell disease French children. Therefore, the investigator need an epidemiologic study about the prevalence of vitamin D deficiency in this

calcium
  • 0 views
  • 24 Mar, 2022
A Study to Evaluate an Electronic Patient Diary in Adult Participants With Sickle Cell Disease

A study to learn the differences in health condition as self-reported by adult participants with Sickle Cell Disease (SCD) who are not on SCD-modifying therapy medicine versus participants that

thalassemia
glutamine
exchange transfusion
hydroxyurea
voxelotor
  • 0 views
  • 15 Jun, 2022
  • 1 location
Sickle Cell Pro-Inflammatory Response to Interval Training Study (SPRINTS)

Recommendations for exercise prescription currently do not exist for individuals with sickle cell anemia (SCA) despite the known impact that SCA-related complications has on physical functioning

asthma
thalassemia
electrophoresis
Accepts healthy volunteers
hemoglobin s
  • 8 views
  • 13 Feb, 2022
  • 3 locations
Evaluation of Left Ventricular Function by Speckle Tracking Echocardiography in Patient Hospitalised in Intensive Care Unit for Vaso-occlusive Crisis

Vaso-occlusive crisis in Sickle cell disease might alter myocardial function through micro vascular obstruction. Evaluation of strain alteration using speckle tracking echocardiography is a non

vaso-occlusive crisis
  • 0 views
  • 26 Jan, 2022
  • 1 location
Hydroxyurea Exposure Limiting Pregnancy and Follow-Up Lactation (HELPFUL)

The purpose of this research study is to document and understand the effects of hydroxyurea exposure for women with SCD and their babies, during both gestation and lactation.

hydroxyurea
  • 5 views
  • 26 Jan, 2022
  • 1 location
Adding Azathioprine/Hydroxyurea Preconditioning to Alemtuzumab/TBI to Reduce Risk of Graft Failure in MSD HSCT in Adult SCD Patients

results in improved disease-free survival and donor chimerism after allo-SCT in SCD patients. Furthermore, the investigators will evaluate whether azathioprine/hydroxyurea preconditioning leads to more

cell transplantation
thalassemia
alemtuzumab
sirolimus
hydroxyurea
  • 0 views
  • 15 Mar, 2022
  • 1 location
STRIDE Biorepository

The STRIDE Biorepository is an optional substudy available to participants in "Bone Marrow Transplantation vs Standard of Care in Patients with Severe Sickle Cell Disease (BMT CTN 1503

bone marrow transplant
sickle cell trait
chronic pain
thalassemia
blood transfusion
  • 255 views
  • 24 Feb, 2022
  • 34 locations
The Predictive Capacity of Machine Learning Models for Progressive Kidney Disease in Individuals With Sickle Cell Anemia (PREMIER)

This is a multicenter prospective, longitudinal cohort study which will evaluate the predictive capacity of machine learning (ML) models for progression of CKD in eligible patients for a minimum of 12 months and potentially for up to 4 years.

thalassemia
acute pain
  • 0 views
  • 26 Jul, 2022
  • 2 locations
Cerebrovascular Reserve and White Matter Disease in Patients With Chronic Anemia (CVR)

This is primarily an observational trial in patients with chronic anemia syndromes (sickle cell disease and thalassemia) and control subjects. The key purpose is to understand how brain blood

acetazolamide
thalassemia
blood transfusion
transfusion dependent thalassemia
Accepts healthy volunteers
  • 18 views
  • 27 Jul, 2022
  • 1 location
Sickle Cell Hemoglobinopathies and Bone Health

try to understand why individuals with sickle cell disease (SCD) have thinner bones than healthy individuals do. Doctors have already discovered that people with sickle cell disease have very thin

hemoglobinopathy
sickle cell trait
electrophoresis
Accepts healthy volunteers
hemoglobin s
  • 60 views
  • 26 Jan, 2022
  • 1 location