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Found 228 clinical trials
Senicapoc and Dehydrated Stomatocytosis

(KCNN4) channel or the mechanosensitive channel PIEZO1. Senicapoc is a selective blocker of the Gardos channel that has been extensively studied in sickle cell disease and shown to be safe with limited

  • 13 Jun, 2021
  • 1 location
A Study to Find a Suitable Dose of ASP8731 and Check for Medical Problems at Each Dose in Healthy Adults

ASP8731 is a potential new treatment for people with sickle cell disease. Before ASP8731 is available as a treatment, the researchers need to understand how it is processed by and acts upon the

Accepts healthy volunteers
  • 16 Jun, 2022
  • 1 location
RH Genotype Matched RBC Transfusions (RBC)

To determine the feasibility of matching donor red cells by RH genotype for a cohort of chronically transfused patients with SCD.

  • 01 Mar, 2022
  • 1 location
High Dose Steroids in Children With Stroke (PASTA)

This clinical trial deals with focal cerebral arteriopathy and childhood stroke, a rare but devastating condition. Focal cerebral arteriopathy (FCA) is an inflammatory vessel wall disease provoked by infection and there is increasing evidence that inflammatory processes play a crucial role in childhood stroke, influencing the outcome of the disease. …

  • 12 Mar, 2022
  • 3 locations
Role of Blood Management in Perioperative Outcomes

There is currently limited information regarding the role of blood management in the benign gynecologic population and specifically, in patients who are scheduled to undergo surgery for fibroids and/or abnormal uterine bleeding. A thorough search through PubMed and did not reveal any studies on this issue. In 2019 at …

  • 25 Mar, 2022
  • 1 location
CHOICES3: Sickle Cell Disease Parenting CHOICES (CHOICES3)

The study will use web-based data collection (SCKnowIQ) and intervention delivery strategies enhanced by nudges and tailored boosters in a sample of 430 adult men and women, aged 18-35 yr with SCD or SCT, at-risk, and planning within 2 years to have a child free of SCD.

  • 13 Jun, 2022
  • 1 location
SIKAMIC (SIklos on Kidney Function and AlbuMInuria Clinical Trial) (SIKAMIC)

The purpose of this phase IIb, international, multicentre, double-blind, randomised, placebo-controlled study is to determine the effect of hydroxycarbamide on albuminuria after 6 months of treatment in SCD adult patients.

  • 09 Apr, 2022
  • 9 locations
Rollover Study for Patients With Sickle Cell Disease Who Have Completed a Prior Novartis-Sponsored Crizanlizumab Study

This is a multi-center multi-national rollover study to allow continued access to crizanlizumab for patients with sickle cell disease (SCD) who are on crizanlizumab treatment in a Novartis

  • 16 Jun, 2022
  • 19 locations
Study of Dose Confirmation and Safety of Crizanlizumab in Pediatric Sickle Cell Disease Patients

of VOC with or without HU/HC, receiving crizanlizumab for 2 years. The efficacy and safety of crizanlizumab was already demonstrated in adults with sickle cell disease. The approach is to extrapolate

conjugated bilirubin
absolute neutrophil count
sickle hemoglobin
  • 24 May, 2022
  • 68 locations
A Study of Etavopivat in Adults and Adolescents With Sickle Cell Disease (HIBISCUS)

This clinical trial is a Phase 2/3 study that will evaluate the efficacy and safety of etavopivat and test how well etavopivat works compared to placebo to improve the amount of hemoglobin in the blood and to reduce the number of vaso-occlusive crises (times when the blood vessels become blocked …

  • 24 Apr, 2022
  • 54 locations