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Found 295 clinical trials
Cerebral Oxygen Metabolism in Children (COMIC)

The purpose of this research study is to better understand how blood flow and metabolism change can influence brain development in the early decades of life. We will examine brain blood flow and metabolism using magnetic resonance imaging (MRI). The brain's blood vessels expand and constrict to regulate blood flow …

thal
Accepts healthy volunteers
MRI
stroke
sildenafil
  • 0 views
  • 17 Feb, 2022
  • 1 location
Pulmonary Ultrasound in the Diagnosis of Acute Thoracic Syndrome in Vaso-occlusive Sickle Cell Crisis (ECHO-STA)

ATS (acute thoracic syndrome) refers to acute pulmonary involvement in a sickle cell patient. The diagnosis is based on the association of clinical signs (fever or respiratory symptoms) with a recent pulmonary infiltrate on the chest x-ray. The main objective of the study is to evaluate the place of the …

  • 0 views
  • 04 Jun, 2022
  • 1 location
Metabolic and Hemodynamic Reserve in Pediatric SCA

The purpose of this research study is to better understand how blood flow and metabolism change can influence brain development in the early decades of life. SCA participants and healthy controls are age and sex-matched for comparison. Within the SCA cohort, children with infarcts may have thinner cortices than those …

stroke
Accepts healthy volunteers
  • 0 views
  • 27 Apr, 2022
  • 1 location
Intravenous Gammaglobulin for Sickle Cell Pain Crises

The purpose of this study is to determine whether intravenous immune globulin is safe and effective in the acute treatment of pain crises in sickle cell disease. Funding Source: Food and

narcotics
acute pain
thalassemia
  • 21 views
  • 20 Jun, 2022
  • 1 location
Exercise in Child Health (Project REACH)

sickle cell disease (SCD)] imposes physiological constraints on exercise that are not present in otherwise healthy children. Current exercise testing protocols were based on studies of athletes and high

fibrosis
Accepts healthy volunteers
cardiopulmonary exercise testing
  • 0 views
  • 15 May, 2022
  • 1 location
Cognitive Remediation Intervention to Prepare for Transition of Care

adolescents with sickle cell disease for transition of care.

  • 0 views
  • 10 Aug, 2022
  • 1 location
Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation (HaploHCT) Following Reduced Intensity Conditioning (RIC) for Selected High Risk Non-Malignant Diseases

This is a Phase II study for the use of T-cell replete reduced intensity conditioning (RIC) haploidentical donor allogeneic hematopoietic cell transplantation (HaploHCT) for individuals with high-risk non-malignant diseases who lack a suitable HLA-matched sibling donor.

acute chest syndrome
cyclophosphamide
cytopenia
blood disorder
priapism
  • 10 views
  • 04 Jun, 2022
  • 1 location
Psychological Sequelae After Sudden Cardiac Death in the Patient and His Relatives

This study will evaluate and describe the occurrence of Acute traumatic stress and persistence of Post Traumatic Stress Disorder (PTSD) after resuscitated sudden cardiac death (SCD) in patient

anxiety
  • 0 views
  • 20 Jun, 2021
  • 1 location
Effect of Exercise on Biomarkers in SCT

This study measures the effect of exercise on a variety of biomarkers in blood and urine selected to evaluate the physiological pathways of hemolysis, myolysis, thrombosis, inflammation, and renal function in subjects with sickle cell trait. These pathways have been shown to be associated with adverse events in athletes and …

hemolysis
sickle cell trait
Accepts healthy volunteers
  • 0 views
  • 22 Mar, 2022
  • 1 location
Effects of Experimental Sleep Disturbances on Receptor Function of Study Drug

The overall goal of this project is to determine whether common sleep disturbance patterns, sleep continuity disturbance (SCD) and Sleep Fragmentation (SF), alter cerebral study drug receptor

opioid
sleep disturbances
Accepts healthy volunteers
total sleep time
analgesics
  • 202 views
  • 20 Nov, 2021
  • 1 location