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Found 295 clinical trials
RHD Genotype Matching for Anti-D

This is a pilot study to evaluate the feasibility and safety of providing RH genotype matched D+ Red Blood Cells (RBCs) to chronically transfused patients with sickle cell disease (SCD) who type

hemoglobin s
blood transfusion
sickle hemoglobin
  • 0 views
  • 24 Jul, 2022
  • 1 location
A Phase 3b Study to Evaluate Efficacy and Safety of a Single Dose of Autologous CRISPR Cas9 Modified CD34+ Human Hematopoietic Stem and Progenitor Cells (CTX001) in Subjects With Transfusion-Dependent β-Thalassemia or Severe Sickle Cell Disease

This is a single-dose, open-label study in participants with transfusion-dependent β-thalassemia (TDT) or severe sickle cell disease (SCD). The study will evaluate the safety and efficacy of

ctx001
thalassemia
hemoglobin e
busulfan
  • 0 views
  • 23 Sep, 2022
  • 1 location
The BENeFiTS Trial in Beta Thalassemia Intermedia (PB04-001)

larger subject groups with beta thalassemia and other hemoglobinopathies, such as sickle cell disease.

thalassemia
  • 0 views
  • 03 May, 2022
  • 4 locations
Management of Severe Acute Malnutrition in Children With Sickle Cell Disease Greater Than 5 Years of Age Living in Northern Nigeria

feasibility trial is to identify whether families of children with sickle cell anemia (SCA) > 5 years of age agree to participate over a 12-week period. The investigators will also establish a safety

hydroxyurea
Accepts healthy volunteers
  • 0 views
  • 23 Sep, 2022
  • 2 locations
Daily Vitamin D for Sickle-cell Respiratory Complications (ViDAS-2)

This study aims to answer the question whether daily oral vitamin D supplementation can reduce the risk of respiratory or lung complications in children and adolescents with sickle cell disease

thalassemia
beta-thalassemia
haemoglobin
sickle cell anemia
vitamin d supplementation
  • 1 views
  • 15 Jul, 2022
  • 1 location
Pilot Study PBSCT With TCRab Depletion For Hemoglobinopathies

depletion of unrelated donor (URD) grafts using the CliniMACS device in patients with sickle cell disease (SCD) and beta thalassemia major (BTM).

splenic sequestration
beta thalassemia
cell transplantation
chest syndrome
thalassemia
  • 0 views
  • 25 Mar, 2022
  • 1 location
The Selective Cytopheretic Device (SCD) for Acute Kidney Injury (AKI) and Hepatorenal Syndrome (HRS) Type I

This research study is being done to learn what effect 7 days of treatment with the Selective Cytopheretic Device (SCD) will have on these white blood cells in the bloodstream of patients with

renal replacement therapy
renal failure
glomerular filtration rate
dialysis
ascites
  • 0 views
  • 11 Jul, 2022
  • 1 location
A Program to Increase Sickle Cell Trait Knowledge Among Parent of Young Children Identified in Newborn Screening (SCTaware)

This is a study for parents of young children with Sickle Cell Trait (SCT) identified by newborn screening who are referred and present for in person SCT education at the Institution. The study will determine the feasibility of implementing a SCT education program (SCTaware) that is appropriate for all parents, …

sickle hemoglobin
Accepts healthy volunteers
sickle cell trait
hemoglobin s
  • 2 views
  • 15 May, 2022
  • 1 location
Evaluation of the Safety,Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects With Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of Mitapivat

Background Sickle cell disease (SCD) is a disorder that causes episodes of acute pain and progressive organ damage. Ways to manage SCD have evolved slowly

electrophoresis
glomerular filtration rate
acute pain
hemolysis
absolute neutrophil count
  • 0 views
  • 21 Sep, 2022
  • 1 location
Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-Thalassemia in Individuals With Higher Risk of Transplant Failure

Background Some sickle cell disease or beta-thalassemia can be cured with transplant. Researchers want to test a variation of transplant that uses low dose

thal
cyclophosphamide
immunosuppressive agents
thalidomide
iron overload
  • 43 views
  • 18 Sep, 2022
  • 1 location