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Found 296 clinical trials
A Multicentre Trial Evaluating the Efficacy and Safety of Oral Decitabine Tetrahydrouridine (NDec) in Patients With Sickle Cell Disease (ASCENT1)

This study will look at how well a potentially new medicine called NDec works and is tolerated in people with sickle cell disease. NDec is a combination of two medicines (decitabine

hydroxyurea
vaso-occlusive crisis
  • 0 views
  • 23 Sep, 2022
  • 2 locations
A 2-Part, Phase 1, Multi-Center, Single-Dose, Open Label, Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of CSL889 in Adult Patients With Sickle Cell Disease

biomarkers of target engagement of CSL889 following single intravenous (IV) doses in subjects with sickle cell disease (SCD). The study involves sequential dose escalation of cohorts with between-group

acute chest syndrome
thalassemia
opioid
voxelotor
glutamine
  • 0 views
  • 16 Sep, 2022
  • 12 locations
Building Adaptive Coping and Knowledge to Improve Daily Life (Back2Life)

The purpose of this study is to find out how teenagers with chronic pain and sickle cell disease respond to a new training program called Back2Life and get their feedback about how to modify the

voxelotor
hydroxyurea
chronic pain
  • 0 views
  • 10 Aug, 2022
  • 3 locations
Voxelotor Neurocognitive Function Study

of Health (NIH) Toolbox Cognition Module of executive abilities in pediatric participants (8 to < 18 years) with SCD.

voxelotor
  • 0 views
  • 21 Mar, 2022
  • 1 location
Study of Crizanlizumab for Prevention of Silent Cerebral Infarcts in SCA (CRIZ)

patients with sickle cell disease. Study participants will undergo brain MRI before initiation of crizanlizumab and at 6 and 30 months after starting crizanlizumab infusions. The crizanlizumab cohort will

  • 0 views
  • 01 May, 2022
  • 1 location
Early Human Leukocyte Antigen (HLA) Matched Sibling Hematopoietic Stem Cell Transplantation

This study aims to enroll 58 pre-adolescent (<13 years) pediatric participants with sickle cell disease (SCD) who have a pre-adolescent sibling bone marrow donor. All participants will go

blood transfusion
transplant conditioning
hemoglobinopathy
chest syndrome
transcranial doppler ultrasonography
  • 23 views
  • 04 Oct, 2022
  • 10 locations
Nonmyeloablative Stem Cell Transplant in Children With Sickle Cell Disease and a Major ABO-Incompatible Matched Sibling Donor (Sickle-AID)

sickle cell disease (SCD) who have a matched related major ABO-incompatible donor. The nonmyeloablative regimen will use alemtuzumab, total body irradiation (TBI) and sirolimus for immune suppression

thalassemia
priapism
blood transfusion
hemoglobin s
transplant conditioning
  • 9 views
  • 26 Jan, 2022
  • 1 location
SCD for CRS in Congestive Heart Failure (CHF) (No Left Ventricular Assist Device)

The purpose of this clinical trial is to see if a new device (SCD) is safe and if it can reduce damage to the kidney enough to allow medications to work to improve heart and kidney function for

ejection fraction
dyspnea
furosemide
aldosterone
edema
  • 0 views
  • 04 Oct, 2022
  • 1 location
A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AG-946 in Healthy Volunteers and in Participants With Sickle Cell Disease

-946. The sickle cell disease (SCD) part of the study will be non-randomized and open-label, and is designed to identify 1 or more safe and tolerable dose(s) of AG-946 with potential activity in the

Accepts healthy volunteers
hydroxyurea
glutamine
  • 19 views
  • 25 Jul, 2022
  • 4 locations
Effects of the Fully Immersive VR Cognitive Training Based on Leisure Activities for the Elderly With MCI and SCD.

Mild cognitive impairment (MCI) and subjective cognitive decline (SCD) are risk groups for dementia, and thus appropriate interventions are required. Cognitive training is a common intervention

  • 0 views
  • 26 Jan, 2022
  • 1 location