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Found 16 clinical trials
Featured trial
Genotype -Phenotype Correlation of PKLR Variants with Pyruvate Kinase, 2,3-Diphosphglycerate and ATP Activities in Red Blood Cells of Patients with Sickle Cell Disease

Background: Some people with the same disorder on a genetic level have more complications than others. Researchers want to look for a link between the PKLR gene and sickle cell disease (SCD) symptoms. The PKLR gene helps create a protein, called pyruvate kinase that is essential in normal functioning of …

sickle cell anemia
sickle cell disease
red blood cell disorder
  • 63 views
  • 22 Dec, 2020
  • 1 location
CHOICES3: Sickle Cell Disease Parenting CHOICES (CHOICES3)

The study will use web-based data collection (SCKnowIQ) and intervention delivery strategies enhanced by nudges and tailored boosters in a sample of 430 adult men and women, aged 18-35 yr with SCD or SCT, at-risk, and planning within 2 years to have a child free of SCD.

electrophoresis
thalassemia
  • 0 views
  • 13 Jun, 2022
  • 1 location
A Program to Increase Sickle Cell Trait Knowledge Among Parent of Young Children Identified in Newborn Screening (SCTaware)

This is a study for parents of young children with Sickle Cell Trait (SCT) identified by newborn screening who are referred and present for in person SCT education at the Institution.

Accepts healthy volunteers
sickle cell trait
sickle hemoglobin
hemoglobin s
  • 2 views
  • 15 May, 2022
  • 1 location
Effect of Exercise on Biomarkers in SCT

renal function in subjects with sickle cell trait. These pathways have been shown to be associated with adverse events in athletes and warfighters with SCT upon protracted, repeated, strenuous exertion

sickle cell trait
Accepts healthy volunteers
hemolysis
  • 0 views
  • 22 Mar, 2022
  • 1 location
Precision Exercise in Children With Malignant Hemopathies

In the early years of life and during adolescence, physical activity is crucial for good development of motor skills. It is even more so for those children and young people who are forced to undergo anti-cancer therapies and therefore undergo long periods of hospitalization (often bedridden) and prolonged periods of …

Accepts healthy volunteers
lymphoma
cancer
leukemia
hematologic disorder
  • 0 views
  • 06 Oct, 2021
Red Cell Half Life Determination in Patients With and Without Sickle Cell Disease

either have SCD, had SCD but were cured with a bone marrow transplant, have the sickle cell trait (SCT), or are a healthy volunteer without SCD or SCT Design

sickle cell trait
anemia
Accepts healthy volunteers
blood disorder
hemoglobin s
  • 0 views
  • 28 Jun, 2022
  • 1 location
A Blood Stem Cell Transplant for Sickle Cell Disease

sickle cell trait. The blood stem cell transplant will be given to the patient as an intravenous infusion (IV). The donor blood stem cells will then make normal red blood cells - as well as other types

transcranial doppler ultrasonography
chest syndrome
thalassemia
blood transfusion
asthma
  • 71 views
  • 03 Mar, 2022
  • 1 location
Collection and Storage of Umbilical Cord Stem Cells for Treatment of Sickle Cell Disease

This study will determine the best ways to collect, process and store umbilical cord blood from babies with sickle cell disease, sickle cell trait and unaffected babies. Sickle cell disease is

sickle cell trait
anemia
sickle hemoglobin
Accepts healthy volunteers
thalassemia
  • 41 views
  • 02 Jul, 2022
  • 1 location
DREPAMASSE Study - Evaluation of a Newborn Screening for Sickle Cell Disease by Tandem Mass Spectrometry (DREPAMASSE)

Three methods are actually used in newborn screening for sickle cell disease (SCD) in France: isoelectric focusing, high performance liquid chromatography and capillary electrophoresis. New technologies are currently under development such as Matrix Assisted Laser Desorption Ionisation - Time of Flight (MALDI-TOF) and tandem mass spectrometry (MS/MS) using the SpOtOn …

electrophoresis
  • 0 views
  • 26 Jan, 2022
  • 2 locations
At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions

We are the missing link in clinical trials, connecting patients and researchers seamlessly and conveniently using a mobile health platform to advance medical research. We make it easy for patients to contribute to research for medical conditions that matter most to them, regardless of their location or ability to travel.

Accepts healthy volunteers
  • 261 views
  • 26 Jan, 2022
  • 1 location