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Found 225 clinical trials
Featured trial
Sickle Cell Disease Research Study - Fulcrum Therapeutics  

The purpose of this study is to determine the safety and clinical effects of SCD-101 when given to adults with sickle cell disease.

thalassemia
hemoglobin f
  • 7156 views
  • 16 Jun, 2022
  • 5 locations
Featured trial
A Study of FT-4202 in Adults and Adolescents With Sickle Cell Disease (Hibiscus Study)

This clinical trial is a Phase 2/3 study that will evaluate the efficacy and safety of FT-4202 and test how well FT-4202 works compared to placebo to improve the amount of hemoglobin in the blood and to reduce the number of vaso-occlusive crises (times when the blood vessels become blocked …

hydroxyurea
  • 13 views
  • 22 Dec, 2021
  • 29 locations
Featured trial
Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease

Background: Peripheral blood stem cell transplantation procedures are used for people with sickle cell disease. Researchers want to improve the success and reduce the

stroke
red blood cell disorder
cell transplantation
sickle cell disease
  • 83 views
  • 22 Dec, 2020
  • 1 location
Featured trial
Sickle Cell Single/Multiple Dose Study

A randomized, placebo-controlled, double blind, single ascending and multiple ascending dose study to assess the safety in healthy volunteers and sickle cell disease. Facility is in Miami, Florida

  • 9 views
  • 25 Jan, 2021
  • 1 location
Featured trial
Genotype -Phenotype Correlation of PKLR Variants with Pyruvate Kinase, 2,3-Diphosphglycerate and ATP Activities in Red Blood Cells of Patients with Sickle Cell Disease

sickle cell disease (SCD) symptoms. The PKLR gene helps create a protein, called pyruvate kinase that is essential in normal functioning of the red blood cell. Differences in the PKLR gene, called genetic

red blood cell disorder
sickle cell anemia
sickle cell disease
  • 63 views
  • 22 Dec, 2020
  • 1 location
Featured trial
H7T-MC-TADO(b): A Phase 3, Double-Blind, Randomized, Efficacy and Safety Comparison of Prasugrel and Placebo in Pediatric Patients With Sickle Cell Disease.

H7T-MC-TADO(b): A Phase 3, Double-Blind, Randomized, Efficacy and Safety Comparison of Prasugrel and Placebo in Pediatric Patients With Sickle Cell Disease.

  • 908 views
  • 08 Nov, 2020
  • 1 location
A Study to Evaluate the Safety and Efficacy of Crizanlizumab in Sickle Cell Disease Related Priapism (SPARTAN)

The goal of the study is to evaluate the efficacy and safety of crizanlizumab in SCD patients with priapism.

  • 24 views
  • 15 Feb, 2022
  • 18 locations
Intravenous Gammaglobulin for Sickle Cell Pain Crises

The purpose of this study is to determine whether intravenous immune globulin is safe and effective in the acute treatment of pain crises in sickle cell disease.

  • 41 views
  • 07 Nov, 2020
  • 1 location
The Impact of Oxidative Stress on Erythrocyte Biology (RBC Survival)

This study will address if red blood cells transfused to a sickle cell patient from a donor with a glucose-6-phosphate-dehydrogenase (G6PD) enzyme deficiency have a different lifespan as measured by the percentage of red blood cells that survive post-transfusion compared to red blood cells transfused to a sickle cell patient …

  • 0 views
  • 10 Mar, 2022
  • 1 location
A Trial for Prevention of Recurrent Ischemic Priapism in Men With Sickle Cell Disease: A Pilot Study (PIN)

To conduct a randomized controlled internal pilot feasibility trial for the prevention of recurrent ischemic priapism referred to as the Priapism in Nigeria (PIN) trial. The study team will enroll a minimum of 30 participants and a maximum of 200 participants. Study investigators hypothesize that hydroxyurea therapy combined with tadalafil …

  • 0 views
  • 29 Apr, 2022
  • 1 location